Gene/Proteome Database (LMPD)

LMPD ID
LMP001677
Gene ID
78894
Species
Mus musculus (Mouse)
Gene Name
acetoacetyl-CoA synthetase
Gene Symbol
Aacs
Synonyms
2210408B16Rik; SUR5
Alternate Names
acetoacetyl-CoA synthetase
Chromosome
5
Map Location
5|5 F
EC Number
6.2.1.16

Proteins

acetoacetyl-CoA synthetase
Refseq ID NP_084486
Protein GI 21313520
UniProt ID Q9D2R0
mRNA ID NM_030210
Length 672
RefSeq Status VALIDATED
MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYNDLYHWSVRSYMDFWAEFWKFSGIVYSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIVKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSVFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHMLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPVETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSSVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKAVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKFPGVWAHGDYCRINPKTGGIIMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKRIRDAIRLGLSARHVPSLILETRGIPYTLNGKKVEVAVKQVMAGRTVEHRGAFSNPETLDLYRDIPELQDF

Gene Information

Entrez Gene ID
78894
Gene Name
acetoacetyl-CoA synthetase
Gene Symbol
Aacs
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0030729 IEA:UniProtKB-EC F acetoacetate-CoA ligase activity
GO:0047760 IEA:Ensembl F butyrate-CoA ligase activity
GO:0060612 IEA:Ensembl P adipose tissue development
GO:0071397 IEA:Ensembl P cellular response to cholesterol
GO:0071333 IEA:Ensembl P cellular response to glucose stimulus
GO:0071394 IEA:Ensembl P cellular response to testosterone stimulus
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0001889 IEA:Ensembl P liver development
GO:0032024 IEA:Ensembl P positive regulation of insulin secretion
GO:0042493 IEA:Ensembl P response to drug
GO:0045471 IEA:Ensembl P response to ethanol
GO:0007584 IEA:Ensembl P response to nutrient
GO:0034201 IEA:Ensembl P response to oleic acid
GO:0014074 IEA:Ensembl P response to purine-containing compound
GO:0042594 IEA:Ensembl P response to starvation
GO:0050872 IEA:Ensembl P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
mmu00650 Butanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR005914 Acetoacetyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
acetoacetyl-CoA synthetase
Protein Entry
AACS_MOUSE
UniProt ID
Q9D2R0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
Function Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). {ECO:0000250}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001677 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21313520 RefSeq NP_084486 672 acetoacetyl-CoA synthetase

Identical Sequences to LMP001677 proteins

Reference Database Accession Length Protein Name
GI:21313520 DBBJ BAE27749.1 672 unnamed protein product [Mus musculus]
GI:21313520 DBBJ BAE41577.1 672 unnamed protein product [Mus musculus]
GI:21313520 DBBJ BAE42076.1 672 unnamed protein product [Mus musculus]
GI:21313520 DBBJ BAE38173.1 672 unnamed protein product [Mus musculus]
GI:21313520 DBBJ BAE38197.1 672 unnamed protein product [Mus musculus]
GI:21313520 SwissProt Q9D2R0.1 672 RecName: Full=Acetoacetyl-CoA synthetase [Mus musculus]

Related Sequences to LMP001677 proteins

Reference Database Accession Length Protein Name
GI:21313520 DBBJ BAE29423.1 672 unnamed protein product [Mus musculus]
GI:21313520 DBBJ BAE41938.1 672 unnamed protein product [Mus musculus]
GI:21313520 DBBJ BAF44057.1 672 acetoacetyl-CoA synthetase [Mus musculus]
GI:21313520 GenBank EDM13550.1 672 acetoacetyl-CoA synthetase, isoform CRA_c [Rattus norvegicus]
GI:21313520 GenBank ADS47662.1 672 Sequence 37 from patent US 7799898
GI:21313520 RefSeq XP_006970725.1 672 PREDICTED: acetoacetyl-CoA synthetase [Peromyscus maniculatus bairdii]