Gene/Proteome Database (LMPD)

LMPD ID
LMP001541
Gene ID
5408
Species
Homo sapiens (Human)
Gene Name
pancreatic lipase-related protein 2
Gene Symbol
PNLIPRP2
Synonyms
PLRP2
Alternate Names
pancreatic lipase-related protein 2; PL-RP2; galactolipase
Chromosome
10
Map Location
10q25.3
EC Number
3.1.1.26

Proteins

pancreatic lipase-related protein 2 precursor
Refseq ID NP_005387
Protein GI 106507261
UniProt ID P54317
mRNA ID NM_005396
Length 470
RefSeq Status VALIDATED
MMLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGESGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKFLWNKRGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1983 peptide sequence: MMLPPWTLGLLLLATVRG

Gene Information

Entrez Gene ID
5408
Gene Name
pancreatic lipase-related protein 2
Gene Symbol
PNLIPRP2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:UniProtKB C extracellular space
GO:0047372 IDA:UniProtKB F acylglycerol lipase activity
GO:0005509 IDA:UniProtKB F calcium ion binding
GO:0047714 IDA:UniProtKB F galactolipase activity
GO:0004620 IDA:UniProtKB F phospholipase activity
GO:0004806 TAS:ProtInc F triglyceride lipase activity
GO:0019376 IDA:UniProtKB P galactolipid catabolic process
GO:0044241 TAS:Reactome P lipid digestion
GO:0009395 IDA:UniProtKB P phospholipid catabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006641 TAS:ProtInc P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_9518 Digestion of dietary lipid

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase-related protein 2
Protein Entry
LIPR2_HUMAN
UniProt ID
P54317
Species
Human

Comments

Comment Type Description
Catalytic Activity 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis. {ECO
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Similarity Contains 1 PLAT domain. {ECO
Subcellular Location Secreted {ECO
Tissue Specificity Pancreas.

Identical and Related Proteins

Unique RefSeq proteins for LMP001541 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
106507261 RefSeq NP_005387 470 pancreatic lipase-related protein 2 precursor

Identical Sequences to LMP001541 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP001541 proteins

Reference Database Accession Length Protein Name
GI:106507261 EMBL CAG33230.1 469 PNLIPRP2 [Homo sapiens]
GI:106507261 GenBank AAA59533.1 469 lipase related protein 2 [Homo sapiens]
GI:106507261 GenBank AAH05989.1 469 PNLIPRP2 protein [Homo sapiens]
GI:106507261 GenBank AAP66255.1 469 Sequence 5 from patent US 6558936
GI:106507261 GenBank EAW49448.1 469 pancreatic lipase-related protein 2, isoform CRA_b [Homo sapiens]
GI:106507261 SwissProt P54317.1 469 RecName: Full=Pancreatic lipase-related protein 2; Short=PL-RP2; AltName: Full=Galactolipase; Flags: Precursor [Homo sapiens]