Gene/Proteome Database (LMPD)

LMPD ID
LMP001484
Gene ID
66113
Species
Mus musculus (Mouse)
Gene Name
apolipoprotein A-V
Gene Symbol
Apoa5
Synonyms
1300007O05Rik; Apoav; RAP3
Alternate Names
apolipoprotein A-V; apo-AV; apoA-V; apolipoprotein A5; regeneration-associated protein 3
Chromosome
9
Map Location
9|9 B

Proteins

apolipoprotein A-V precursor
Refseq ID NP_536682
Protein GI 31560003
UniProt ID Q8C7G5
mRNA ID NM_080434
Length 368
RefSeq Status PROVISIONAL
MAAVITWALALLAVFASTQARKSLWDYFSQNSWSKGVMGQPQKLAQENLKGSFEQDLYNMNNYLEKLGPLRGPGKEPPLLAQDPEGIRKQLQQELGEVSSRLEPYMAAKHQQVGWNLEGLRQQLKPYTAELMEQVGLSVQELQEQLRVVGEDTKAQLLGGVDEALNLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAAASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSAFIRVSTDGAEDGDSLDPQALSEEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLQDQGHSHLSDPEGHSG
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2048 peptide sequence: MAAVITWALALLAVFASTQA mat_peptide: 21..368 product: Apolipoprotein A-V experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8C7G5.1) calculated_mol_wt: 39232 peptide sequence: RKSLWDYFSQNSWSKGVMGQPQKLAQENLKGSFEQDLYNMNNYLEKLGPLRGPGKEPPLLAQDPEGIRKQLQQELGEVSSRLEPYMAAKHQQVGWNLEGLRQQLKPYTAELMEQVGLSVQELQEQLRVVGEDTKAQLLGGVDEALNLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAAASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSAFIRVSTDGAEDGDSLDPQALSEEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLQDQGHSHLSDPEGHSG

Gene Information

Entrez Gene ID
66113
Gene Name
apolipoprotein A-V
Gene Symbol
Apoa5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0008201 IEA:Ensembl F heparin binding
GO:0060230 IEA:Ensembl F lipoprotein lipase activator activity
GO:0031210 IEA:Ensembl F phosphatidylcholine binding
GO:0055090 IMP:BHF-UCL P acylglycerol homeostasis
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0042157 IEA:InterPro P lipoprotein metabolic process
GO:0031100 IEA:Ensembl P organ regeneration
GO:0045723 IEA:Ensembl P positive regulation of fatty acid biosynthetic process
GO:0051006 IEA:Ensembl P positive regulation of lipoprotein lipase activity
GO:0010898 IEA:Ensembl P positive regulation of triglyceride catabolic process
GO:0010902 IEA:Ensembl P positive regulation of very-low-density lipoprotein particle remodeling
GO:0009725 IEA:Ensembl P response to hormone
GO:0042246 IEA:Ensembl P tissue regeneration
GO:0019433 IEA:Ensembl P triglyceride catabolic process
GO:0070328 IEA:Ensembl P triglyceride homeostasis
GO:0006641 IMP:MGI P triglyceride metabolic process
GO:0034370 IMP:MGI P triglyceride-rich lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
mmu03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5893389 Chylomicron-mediated lipid transport
5893843 PPARA activates gene expression

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-V
Protein Entry
APOA5_MOUSE
UniProt ID
Q8C7G5
Species
Mouse

Comments

Comment Type Description
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). {ECO:0000250}.
Induction Induced in early phase of liver regeneration.
Miscellaneous Mice expressing the human APOAV transgene show a decrease in plasma TG by one third. Conversely, knockout mice lacking APOAV have a four time increase in plasma TG.
Ptm Phosphorylation sites are present in the extracellular medium. {ECO:0000250}.
Similarity Belongs to the apolipoprotein A1/A4/E family. {ECO:0000305}.
Subcellular Location Secreted {ECO:0000269|PubMed:11577099}.
Subunit Interacts with GPIHBP1. {ECO:0000250}.
Tissue Specificity Liver. {ECO:0000269|PubMed:11577099, ECO:0000269|PubMed:11588264}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001484 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31560003 RefSeq NP_536682 368 apolipoprotein A-V precursor

Identical Sequences to LMP001484 proteins

Reference Database Accession Length Protein Name
GI:31560003 DBBJ BAC34163.1 368 unnamed protein product [Mus musculus]
GI:31560003 GenBank EDL25685.1 368 apolipoprotein A-V [Mus musculus]
GI:31560003 RefSeq XP_006510601.1 368 PREDICTED: apolipoprotein A-V isoform X1 [Mus musculus]
GI:31560003 SwissProt Q8C7G5.1 368 RecName: Full=Apolipoprotein A-V; Short=Apo-AV; Short=ApoA-V; AltName: Full=Apolipoprotein A5; AltName: Full=Regeneration-associated protein 3; Flags: Precursor [Mus musculus]

Related Sequences to LMP001484 proteins

Reference Database Accession Length Protein Name
GI:31560003 GenBank AAF25660.1 367 apolipoprotein A5 [Rattus norvegicus]
GI:31560003 GenBank AAG49600.1 368 apolipoprotein A5 [Mus musculus]
GI:31560003 GenBank AAH11198.1 368 Apolipoprotein A-V [Mus musculus]
GI:31560003 GenBank AAH89780.1 367 Apoa5 protein [Rattus norvegicus]
GI:31560003 RefSeq NP_542143.1 367 apolipoprotein A-V precursor [Rattus norvegicus]
GI:31560003 RefSeq NP_001264193.1 367 apolipoprotein A-V precursor [Rattus norvegicus]