Gene/Proteome Database (LMPD)

LMPD ID
LMP001394
Gene ID
5737
Species
Homo sapiens (Human)
Gene Name
prostaglandin F receptor (FP)
Gene Symbol
PTGFR
Synonyms
FP
Alternate Names
prostaglandin F2-alpha receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor; prostaglandin F2 alpha receptor; prostaglandin receptor (2-alpha)
Chromosome
1
Map Location
1p31.1
Summary
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PTGFR

Proteins

prostaglandin F2-alpha receptor isoform a precursor
Refseq ID NP_000950
Protein GI 4506261
UniProt ID P43088
mRNA ID NM_000959
Length 359
RefSeq Status REVIEWED
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
prostaglandin F2-alpha receptor isoform b precursor
Refseq ID NP_001034674
Protein GI 88758606
UniProt ID P43088
mRNA ID NM_001039585
Length 297
RefSeq Status REVIEWED
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLGYRIILNGKEKYKVYEEQSDFLHRLQWPTLE
sig_peptide: 1..25 calculated_mol_wt: 2640 peptide sequence: MSMNNSKQLVSPAAALLSNTTCQTE mat_peptide: 26..359 product: prostaglandin F2-alpha receptor isoform a calculated_mol_wt: 37433 peptide sequence: NRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST sig_peptide: 1..25 calculated_mol_wt: 2640 peptide sequence: MSMNNSKQLVSPAAALLSNTTCQTE mat_peptide: 26..297 product: prostaglandin F2-alpha receptor isoform b calculated_mol_wt: 31031 peptide sequence: NRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLGYRIILNGKEKYKVYEEQSDFLHRLQWPTLE

Gene Information

Entrez Gene ID
5737
Gene Name
prostaglandin F receptor (FP)
Gene Symbol
PTGFR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005576 IDA:MGI C extracellular region
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0004958 IDA:UniProtKB F prostaglandin F receptor activity
GO:0007186 TAS:ProtInc P G-protein coupled receptor signaling pathway
GO:0035584 IDA:UniProtKB P calcium-mediated signaling using intracellular calcium source
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0007567 TAS:ProtInc P parturition
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
hsa04020 Calcium signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000141 Prostaglandin F receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin F receptor (FP)
Protein Entry
PF2R_HUMAN
UniProt ID
P43088
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P43088-1; Sequence=Displayed; Name=2; Synonyms=FP(S), VAR-1; IsoId=P43088-2; Sequence=VSP_042025; Name=3; Synonyms=VAR-2; IsoId=P43088-3; Sequence=VSP_053589, VSP_053595; Name=4; Synonyms=VAR-3; IsoId=P43088-4; Sequence=VSP_053588, VSP_053596; Name=5; Synonyms=altFP4, VAR-4; IsoId=P43088-5; Sequence=VSP_053593, VSP_053597; Name=6; Synonyms=VAR-5; IsoId=P43088-6; Sequence=VSP_053591, VSP_053592; Name=7; Synonyms=VAR-6; IsoId=P43088-7; Sequence=VSP_053590, VSP_053594;
Function Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Isoform 1 can form heterodimers with isoform 5 (and probably other isoforms).
Tissue Specificity Eye.

Identical and Related Proteins

Unique RefSeq proteins for LMP001394 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4506261 RefSeq NP_000950 359 prostaglandin F2-alpha receptor isoform a precursor
88758606 RefSeq NP_001034674 297 prostaglandin F2-alpha receptor isoform b precursor

Identical Sequences to LMP001394 proteins

Reference Database Accession Length Protein Name
GI:4506261 DBBJ BAG74185.1 359 prostaglandin F receptor, partial [synthetic construct]
GI:88758606 EMBL CAI53641.1 297 unnamed protein product [Homo sapiens]
GI:88758606 GenBank AAR84381.1 297 FP prostanoid receptor [Homo sapiens]
GI:88758606 GenBank EAX06351.1 297 prostaglandin F receptor (FP), isoform CRA_b [Homo sapiens]
GI:88758606 GenBank ABZ62032.1 297 Sequence 2 from patent US 7320871
GI:4506261 GenBank ABZ62038.1 359 Sequence 14 from patent US 7320871
GI:88758606 GenBank ACE46356.1 297 Sequence 25 from patent US 7378492
GI:4506261 GenBank AEF74524.1 359 Sequence 105 from patent US 7939268
GI:4506261 GenBank AEH18183.1 359 Sequence 105 from patent US 7951546
GI:4506261 GenBank AIC49526.1 359 hypothetical protein, partial [synthetic construct]
GI:4506261 RefSeq XP_006710844.1 359 PREDICTED: prostaglandin F2-alpha receptor isoform X1 [Homo sapiens]

Related Sequences to LMP001394 proteins

Reference Database Accession Length Protein Name
GI:88758606 EMBL CAI53643.1 291 unnamed protein product [Homo sapiens]
GI:4506261 GenBank AAX29962.1 360 prostaglandin F receptor, partial [synthetic construct]
GI:88758606 GenBank ABZ62034.1 291 Sequence 6 from patent US 7320871
GI:4506261 GenBank JAA16360.1 359 prostaglandin F receptor (FP) [Pan troglodytes]
GI:4506261 GenBank JAA26554.1 359 prostaglandin F receptor (FP) [Pan troglodytes]
GI:4506261 GenBank JAA36212.1 359 prostaglandin F receptor (FP) [Pan troglodytes]
GI:4506261 RefSeq XP_513513.2 359 PREDICTED: prostaglandin F2-alpha receptor [Pan troglodytes]
GI:4506261 RefSeq XP_003807822.1 359 PREDICTED: prostaglandin F2-alpha receptor [Pan paniscus]
GI:88758606 RefSeq XP_004026070.1 297 PREDICTED: prostaglandin F2-alpha receptor isoform 2 [Gorilla gorilla gorilla]
GI:88758606 RefSeq XP_004026071.1 297 PREDICTED: prostaglandin F2-alpha receptor isoform 3 [Gorilla gorilla gorilla]
GI:88758606 RefSeq XP_007976393.1 290 PREDICTED: prostaglandin F2-alpha receptor isoform X2 [Chlorocebus sabaeus]
GI:88758606 RefSeq XP_009246994.1 290 PREDICTED: prostaglandin F2-alpha receptor isoform X2 [Pongo abelii]