Gene/Proteome Database (LMPD)

LMPD ID
LMP001329
Gene ID
101502
Species
Mus musculus (Mouse)
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Gene Symbol
Hsd3b7
Synonyms
AI195443; BB098564
Alternate Names
3 beta-hydroxysteroid dehydrogenase type 7; 3-beta-HSD VII; c(27) 3-beta-HSD; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
Chromosome
7
Map Location
7 F3|7
EC Number
1.1.1.-

Proteins

3 beta-hydroxysteroid dehydrogenase type 7 isoform a
Refseq ID NP_598704
Protein GI 100817045
UniProt ID Q9EQC1
mRNA ID NM_133943
Length 369
RefSeq Status VALIDATED
MADSAQVPTLVYLVTGGCGFLGEHIVRMLLEREPRLRELRVFDLHLSSWLEELKAGPVQVTAIQGDVTQAHEVAAAMSGSHVVIHTAGLVDVFGKASPKTIHKVNVQGTQNVIDACVQTGTQYLVYTSSMEVVGPNIKGHPFYRGNEDTPYEAVHSHPYPCSKALAEQLVLEANGRKVNGGLPLVTCALRPTGIYGEGHQVMRDFYYQGLRFGGRLFRAVPASVEHGRVYVGNVAWMHILVARELEQRAALMGGQVYFCYDKSPYKSYEDFNMEFLSPCGLRLIGAHPLLPYWLLVLLATLNALLQWLLRPLVLYTPLLNPYTLAMANTTFTVSTNKAQRHFGYKPLFSWEESRTRTIQWVQAMEGSAR

Gene Information

Entrez Gene ID
101502
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Gene Symbol
Hsd3b7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003854 IEA:InterPro F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0047016 IEA:UniProtKB-EC F cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
GO:0006694 IEA:UniProtKB-UniPathway P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00120 Primary bile acid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893443 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
5893439 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5893441 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Protein Entry
3BHS7_MOUSE
UniProt ID
Q9EQC1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = 3- oxo-Delta(5)-steroid + NADH.
Catalytic Activity Cholest-5-ene-3-beta,7-alpha-diol + NAD(+) = 7-alpha-hydroxycholest-4-en-3-one + NADH.
Function The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Predominantly expressed in liver. {ECO:0000269|PubMed:11067870}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001329 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
100817045 RefSeq NP_598704 369 3 beta-hydroxysteroid dehydrogenase type 7 isoform a

Identical Sequences to LMP001329 proteins

Reference Database Accession Length Protein Name
GI:100817045 GenBank AAG37823.1 369 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase [Mus musculus]
GI:100817045 GenBank AAI32606.1 369 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Mus musculus]
GI:100817045 GenBank AAI38590.1 369 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Mus musculus]
GI:100817045 SwissProt Q9EQC1.1 369 RecName: Full=3 beta-hydroxysteroid dehydrogenase type 7; AltName: Full=3 beta-hydroxysteroid dehydrogenase type VII; Short=3-beta-HSD VII; AltName: Full=3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; Short=C(27) 3-beta-HSD; AltName: Full=Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase [Mus musculus]

Related Sequences to LMP001329 proteins

Reference Database Accession Length Protein Name
GI:100817045 GenBank EDM17233.1 369 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7, isoform CRA_c [Rattus norvegicus]
GI:100817045 GenBank ERE79047.1 369 3 beta-hydroxysteroid dehydrogenase type 7 [Cricetulus griseus]
GI:100817045 RefSeq XP_005064402.1 369 PREDICTED: 3 beta-hydroxysteroid dehydrogenase type 7 isoform X1 [Mesocricetus auratus]
GI:100817045 RefSeq XP_005351368.1 369 PREDICTED: 3 beta-hydroxysteroid dehydrogenase type 7 isoform X1 [Microtus ochrogaster]
GI:100817045 RefSeq XP_005351369.1 369 PREDICTED: 3 beta-hydroxysteroid dehydrogenase type 7 isoform X2 [Microtus ochrogaster]
GI:100817045 RefSeq XP_006230274.1 369 PREDICTED: 3 beta-hydroxysteroid dehydrogenase type 7 isoform X1 [Rattus norvegicus]