Gene/Proteome Database (LMPD)

LMPD ID
LMP001316
Gene ID
13666
Species
Mus musculus (Mouse)
Gene Name
eukaryotic translation initiation factor 2 alpha kinase 3
Gene Symbol
Eif2ak3
Synonyms
AI427929; Pek; Perk
Chromosome
6
Map Location
6 C1|6

Proteins

eukaryotic translation initiation factor 2-alpha kinase 3 precursor
Refseq ID NP_034251
Protein GI 124001564
UniProt ID Q7TQC8
mRNA ID NM_010121
Length 1114
RefSeq Status VALIDATED
MERATRPGPRALLLLLFLLLGCAAGISAVAPARSLLAPASETVFGLGAAAAPTSAARVPAVATAEVTVEDAEALPAAAGEPESRATEPDDDVELRPRGRSLVIISTLDGRIAALDAENDGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKLRYICSALGCRRWDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKPGGNKEDSKIISDVEEQEATMLDTVIKVSVADWKVMAFSRKGGRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTASEEALGDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTSPKALESVNGENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTFIVRRLFHPQPHRQRKESETQCQTESKYDSVSADVSDNSWNDMKYSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKEQIEVIAPSPERSRSFSVGISCGQTSSSESQFSPLEFSGTDCGDNSDSADAAYNLQDSCLTDCEDVEDGTVDGNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLKCSSSRSSSEATTLSTSPTRPTTLSLDFTKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIFENLEFPGKTVLRQRSRSMSSSGTKHSRQPSCSYSPLPGN
sig_peptide: 1..28 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2925 peptide sequence: MERATRPGPRALLLLLFLLLGCAAGISA mat_peptide: 29..1114 product: Eukaryotic translation initiation factor 2-alpha kinase 3 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9Z2B5.1) calculated_mol_wt: 121764 peptide sequence: VAPARSLLAPASETVFGLGAAAAPTSAARVPAVATAEVTVEDAEALPAAAGEPESRATEPDDDVELRPRGRSLVIISTLDGRIAALDAENDGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKLRYICSALGCRRWDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKPGGNKEDSKIISDVEEQEATMLDTVIKVSVADWKVMAFSRKGGRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTASEEALGDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTSPKALESVNGENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTFIVRRLFHPQPHRQRKESETQCQTESKYDSVSADVSDNSWNDMKYSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKEQIEVIAPSPERSRSFSVGISCGQTSSSESQFSPLEFSGTDCGDNSDSADAAYNLQDSCLTDCEDVEDGTVDGNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLKCSSSRSSSEATTLSTSPTRPTTLSLDFTKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIFENLEFPGKTVLRQRSRSMSSSGTKHSRQPSCSYSPLPGN

Gene Information

Entrez Gene ID
13666
Gene Name
eukaryotic translation initiation factor 2 alpha kinase 3
Gene Symbol
Eif2ak3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005789 IDA:MGI C endoplasmic reticulum membrane
GO:0005524 IEA:InterPro F ATP binding
GO:0004694 IEA:Ensembl F eukaryotic translation initiation factor 2alpha kinase activity
GO:0004672 IDA:MGI F protein kinase activity
GO:0004674 IDA:MGI F protein serine/threonine kinase activity
GO:0006983 IEA:Ensembl P ER overload response
GO:0032933 IDA:MGI P SREBP signaling pathway
GO:0006919 IMP:MGI P activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282 IMP:MGI P bone mineralization
GO:0019722 IMP:MGI P calcium-mediated signaling
GO:0002063 IMP:MGI P chondrocyte development
GO:0031018 IEA:Ensembl P endocrine pancreas development
GO:0007029 IMP:MGI P endoplasmic reticulum organization
GO:0030968 IDA:MGI P endoplasmic reticulum unfolded protein response
GO:0045444 IDA:MGI P fat cell differentiation
GO:0048009 IMP:MGI P insulin-like growth factor receptor signaling pathway
GO:0070059 IMP:MGI P intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007595 IMP:MGI P lactation
GO:0043066 IMP:MGI P negative regulation of apoptotic process
GO:0010629 IMP:MGI P negative regulation of gene expression
GO:0031642 IMP:MGI P negative regulation of myelination
GO:0017148 IDA:MGI P negative regulation of translation
GO:0032055 IEA:Ensembl P negative regulation of translation in response to stress
GO:0031016 IMP:MGI P pancreas development
GO:1902237 IGI:MGI P positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0032092 IMP:MGI P positive regulation of protein binding
GO:0009967 IDA:MGI P positive regulation of signal transduction
GO:0046777 IDA:MGI P protein autophosphorylation
GO:0051260 IEA:Ensembl P protein homooligomerization
GO:0006468 IDA:MGI P protein phosphorylation
GO:0019217 IMP:MGI P regulation of fatty acid metabolic process
GO:0001501 IMP:MGI P skeletal system development
GO:0006412 IDA:MGI P translation

Domain Information

InterPro Annotations

Accession Description
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR027295 Quinonprotein_ADH-like_fam
IPR008271 Serine/threonine-protein kinase, active site

UniProt Annotations

Entry Information

Gene Name
eukaryotic translation initiation factor 2 alpha kinase 3
Protein Entry
E9QQ30_MOUSE
UniProt ID
Q7TQC8
Species
Mouse

Identical and Related Proteins

Unique RefSeq proteins for LMP001316 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124001564 RefSeq NP_034251 1114 eukaryotic translation initiation factor 2-alpha kinase 3 precursor

Identical Sequences to LMP001316 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP001316 proteins

Reference Database Accession Length Protein Name
GI:124001564 GenBank AAC83801.1 1108 pancreatic eukaryotic initiation factor 2 alpha-subunit kinase [Rattus norvegicus]
GI:124001564 GenBank AAD03337.1 1114 type-I transmembrane ER-resident serine/threonine kinase PERK [Mus musculus]
GI:124001564 GenBank AAH54809.1 1114 Eukaryotic translation initiation factor 2 alpha kinase 3 [Mus musculus]
GI:124001564 GenBank EDL90978.1 1108 eukaryotic translation initiation factor 2 alpha kinase 3, isoform CRA_a [Rattus norvegicus]
GI:124001564 RefSeq NP_113787.1 1108 eukaryotic translation initiation factor 2-alpha kinase 3 precursor [Rattus norvegicus]
GI:124001564 SwissProt Q9Z2B5.1 1114 RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 3; AltName: Full=PRKR-like endoplasmic reticulum kinase; AltName: Full=Pancreatic eIF2-alpha kinase; Flags: Precursor [Mus musculus]