Gene/Proteome Database (LMPD)

LMPD ID
LMP001293
Gene ID
1902
Species
Homo sapiens (Human)
Gene Name
lysophosphatidic acid receptor 1
Gene Symbol
LPAR1
Synonyms
EDG2; GPR26; Gpcr26; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1
Chromosome
9
Map Location
9q31.3
Summary
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for LPAR1

Proteins

lysophosphatidic acid receptor 1
Refseq ID NP_001392
Protein GI 16950636
UniProt ID Q5VZX0
mRNA ID NM_001401
Length 364
RefSeq Status REVIEWED
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
lysophosphatidic acid receptor 1
Refseq ID NP_476500
Protein GI 16950638
UniProt ID Q5VZX0
mRNA ID NM_057159
Length 364
RefSeq Status REVIEWED
Protein sequence is identical to GI:16950636 (mRNA isoform)

Gene Information

Entrez Gene ID
1902
Gene Name
lysophosphatidic acid receptor 1
Gene Symbol
LPAR1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0043198 IEA:Ensembl C dendritic shaft
GO:0043197 IEA:Ensembl C dendritic spine
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:Ensembl C plasma membrane
GO:0070915 IEA:InterPro F lysophosphatidic acid receptor activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0000187 IEA:Ensembl P activation of MAPK activity
GO:0032060 IEA:Ensembl P bleb assembly
GO:0071453 IEA:Ensembl P cellular response to oxygen levels
GO:0042552 IEA:Ensembl P myelination
GO:0010977 IEA:Ensembl P negative regulation of neuron projection development
GO:0035025 IEA:Ensembl P positive regulation of Rho protein signal transduction
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0051482 IEA:Ensembl P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060999 IEA:Ensembl P positive regulation of dendritic spine development
GO:0071673 IEA:Ensembl P positive regulation of smooth muscle cell chemotaxis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04540 Gap junction
hsa04151 PI3K-Akt signaling pathway
hsa04015 Rap1 signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004065 Lysophosphatidic acid receptor
IPR002277 Lysophosphatidic acid receptor EDG-2

UniProt Annotations

Entry Information

Gene Name
lysophosphatidic acid receptor 1
Protein Entry
LPAR1_HUMAN
UniProt ID
Q5VZX0
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001293 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16950636 RefSeq NP_001392 364 lysophosphatidic acid receptor 1

Identical Sequences to LMP001293 proteins

Reference Database Accession Length Protein Name
GI:16950636 GenBank AHD80391.1 364 Sequence 32512 from patent US 8586006
GI:16950636 GenBank AIC48673.1 364 LPAR1, partial [synthetic construct]
GI:16950636 RefSeq XP_008961505.1 364 PREDICTED: lysophosphatidic acid receptor 1 [Pan paniscus]
GI:16950636 RefSeq XP_009455355.1 364 PREDICTED: lysophosphatidic acid receptor 1 [Pan troglodytes]
GI:16950636 RefSeq XP_009455356.1 364 PREDICTED: lysophosphatidic acid receptor 1 [Pan troglodytes]
GI:16950636 RefSeq XP_009455357.1 364 PREDICTED: lysophosphatidic acid receptor 1 [Pan troglodytes]

Related Sequences to LMP001293 proteins

Reference Database Accession Length Protein Name
GI:16950636 GenBank AAX42671.1 365 endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2, partial [synthetic construct]
GI:16950636 GenBank ABN36000.1 373 Sequence 2 from patent US 7169612
GI:16950636 RefSeq XP_005581143.1 364 PREDICTED: lysophosphatidic acid receptor 1 isoform X2 [Macaca fascicularis]
GI:16950636 RefSeq XP_005581144.1 364 PREDICTED: lysophosphatidic acid receptor 1 isoform X3 [Macaca fascicularis]
GI:16950636 RefSeq XP_005581145.1 364 PREDICTED: lysophosphatidic acid receptor 1 isoform X4 [Macaca fascicularis]
GI:16950636 RefSeq XP_010363867.1 364 PREDICTED: lysophosphatidic acid receptor 1 [Rhinopithecus roxellana]