Gene/Proteome Database (LMPD)

LMPD ID
LMP001252
Gene ID
233011
Species
Mus musculus (Mouse)
Gene Name
inositol 1,4,5-trisphosphate 3-kinase C
Gene Symbol
Itpkc
Synonyms
9130023N17Rik
Alternate Names
inositol-trisphosphate 3-kinase C; IP3K C; IP3 3-kinase C; insP 3-kinase C
Chromosome
7
Map Location
7 A3|7
EC Number
2.7.1.127

Proteins

inositol-trisphosphate 3-kinase C
Refseq ID NP_853624
Protein GI 31712006
UniProt ID Q7TS72
mRNA ID NM_181593
Length 678
RefSeq Status PROVISIONAL
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGLVVASEKPRQNKELDGSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRASLCTQPGFDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGVSKLQTHPVCLSPESSADNSGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTESALTQPGTDGLRDDSVLGESNGNDPLDLSEPGELVTNLCSHLECSSLCPVPRLIITPETPEPEAQPVGPQSRIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRAGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPAYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILRKYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGYLWGLDNLICLLQGLAQS

Gene Information

Entrez Gene ID
233011
Gene Name
inositol 1,4,5-trisphosphate 3-kinase C
Gene Symbol
Itpkc
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008440 IDA:MGI F inositol-1,4,5-trisphosphate 3-kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5894025 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol 1,4,5-trisphosphate 3-kinase C
Protein Entry
IP3KC_MOUSE
UniProt ID
Q7TS72
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme Regulation Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4 (By similarity). {ECO:0000250}.
Function Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}.
Interaction O54824:Il16; NbExp=3; IntAct=EBI-648015, EBI-641708;
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001252 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31712006 RefSeq NP_853624 678 inositol-trisphosphate 3-kinase C

Identical Sequences to LMP001252 proteins

Reference Database Accession Length Protein Name
GI:31712006 GenBank AAH53450.1 678 Inositol 1,4,5-trisphosphate 3-kinase C [Mus musculus]
GI:31712006 SwissProt Q7TS72.1 678 RecName: Full=Inositol-trisphosphate 3-kinase C; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase C; Short=IP3 3-kinase C; Short=IP3K C; Short=InsP 3-kinase C [Mus musculus]

Related Sequences to LMP001252 proteins

Reference Database Accession Length Protein Name
GI:31712006 DBBJ BAE32904.1 678 unnamed protein product [Mus musculus]
GI:31712006 EMBL CAD29464.1 678 inositol 1,4,5-trisphosphate 3-kinase [Rattus norvegicus]
GI:31712006 GenBank EDL24195.1 669 inositol 1,4,5-trisphosphate 3-kinase C, partial [Mus musculus]
GI:31712006 GenBank EDM07966.1 678 inositol 1,4,5-trisphosphate 3-kinase C [Rattus norvegicus]
GI:31712006 RefSeq NP_835195.1 678 inositol-trisphosphate 3-kinase C [Rattus norvegicus]
GI:31712006 SwissProt Q80ZG2.1 678 RecName: Full=Inositol-trisphosphate 3-kinase C; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase C; Short=IP3 3-kinase C; Short=IP3K C; Short=InsP 3-kinase C [Rattus norvegicus]