Gene/Proteome Database (LMPD)
LMPD ID
LMP001206
Gene ID
Species
Homo sapiens (Human)
Gene Name
ATPase, class V, type 10A
Gene Symbol
Synonyms
ATP10C; ATPVA; ATPVC
Alternate Names
probable phospholipid-transporting ATPase VA; ATPase, Class V, type 10C; aminophospholipid translocase VA; phospholipid-transporting ATPase VA; P4-ATPase flippase complex alpha subunit ATP10A; ATPase type IV, phospholipid transporting (P-type)
Chromosome
15
Map Location
15q11.2
EC Number
3.6.3.1
Summary
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| probable phospholipid-transporting ATPase VA | |
|---|---|
| Refseq ID | NP_077816 |
| Protein GI | 14424433 |
| UniProt ID | O60312 |
| mRNA ID | NM_024490 |
| Length | 1499 |
| RefSeq Status | REVIEWED |
| MEREPAGTEEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGERRRRRGCAQHLADNRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCIIHDNGKKAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVPKSDGSSLSPVTAAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQEADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDKSLAVARHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKSPVKTIEDFLRRFTPSCLTSGCSSIGSLAANKSSHKLGSSFPSTPSSDGMLLRLEERLGQPTSAIASNGYSSQADNWASELAQEQESERELRYEAESPDEAALVYAARAYNCVLVERLHDQVSVELPHLGRLTFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDEEVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTASGRRPSLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQNMEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIALLTFLLHLGIETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGDPVFYLTCLMTPVAALLPRLFFRSLQGRVFPTQLQLARQLTRKSPRRCSAPKETFAQGRLPKDSGTEHSSGRTVKTSVPLSQPSWHTQQPVCSLEASGEPSTVDMSMPVREHTLLEGLSAPAPMSSAPGEAVLRSPGGCPEESKVRAASTGRVTPLSSLFSLPTFSLLNWISSWSLVSRLGSVLQFSRTEQLADGQAGRGLPVQPHSGRSGLQGPDHRLLIGASSRRSQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0016021 | NAS:UniProtKB | C | integral component of membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0019829 | IEA:InterPro | F | cation-transporting ATPase activity |
| GO:0000287 | IEA:InterPro | F | magnesium ion binding |
| GO:0004012 | NAS:UniProtKB | F | phospholipid-translocating ATPase activity |
| GO:0034220 | TAS:Reactome | P | ion transmembrane transport |
| GO:0045332 | NAS:UniProtKB | P | phospholipid translocation |
| GO:0008360 | NAS:UniProtKB | P | regulation of cell shape |
| GO:0055085 | TAS:Reactome | P | transmembrane transport |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_25300 | Ion channel transport |
| REACT_25149 | Ion transport by P-type ATPases |
| REACT_15518 | Transmembrane transport of small molecules |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60312-1; Sequence=Displayed; Name=2; IsoId=O60312-2; Sequence=VSP_056604, VSP_056605; Note=No experimental confirmation available.; |
| Catalytic Activity | ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). |
| Disease | Angelman syndrome (AS) [MIM |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). |
| Similarity | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane . Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B. |
| Subunit | Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. |
| Tissue Specificity | Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001206 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 14424433 | RefSeq | NP_077816 | 1499 | probable phospholipid-transporting ATPase VA |
Identical Sequences to LMP001206 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14424433 | DBBJ | BAB47392.1 | 1499 | putative aminophospholipid translocase [Homo sapiens] |
| GI:14424433 | GenBank | AAH52251.1 | 1499 | ATPase, class V, type 10A [Homo sapiens] |
| GI:14424433 | GenBank | ACE86498.1 | 1499 | ATPase, class V, type 10A protein, partial [synthetic construct] |
| GI:14424433 | GenBank | ACE87179.1 | 1499 | ATPase, class V, type 10A protein [synthetic construct] |
| GI:14424433 | RefSeq | XP_005268318.1 | 1499 | PREDICTED: probable phospholipid-transporting ATPase VA isoform X1 [Homo sapiens] |
| GI:14424433 | SwissProt | O60312.2 | 1499 | RecName: Full=Probable phospholipid-transporting ATPase VA; AltName: Full=ATPase class V type 10A; AltName: Full=Aminophospholipid translocase VA; AltName: Full=P4-ATPase flippase complex alpha subunit ATP10A [Homo sapiens] |
Related Sequences to LMP001206 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14424433 | GenBank | EAW57650.1 | 1499 | ATPase, Class V, type 10A, isoform CRA_d [Homo sapiens] |
| GI:14424433 | RefSeq | XP_001108767.1 | 1493 | PREDICTED: probable phospholipid-transporting ATPase VA-like [Macaca mulatta] |
| GI:14424433 | RefSeq | XP_510255.2 | 1499 | PREDICTED: probable phospholipid-transporting ATPase VA isoform X1 [Pan troglodytes] |
| GI:14424433 | RefSeq | XP_001161533.1 | 1499 | PREDICTED: probable phospholipid-transporting ATPase VA isoform X1 [Pan troglodytes] |
| GI:14424433 | RefSeq | XP_003828116.1 | 1474 | PREDICTED: probable phospholipid-transporting ATPase VA, partial [Pan paniscus] |
| GI:14424433 | RefSeq | XP_005559074.1 | 1493 | PREDICTED: probable phospholipid-transporting ATPase VA-like isoform X2 [Macaca fascicularis] |