Gene/Proteome Database (LMPD)

LMPD ID
LMP001106
Gene ID
20397
Species
Mus musculus (Mouse)
Gene Name
sphingosine phosphate lyase 1
Gene Symbol
Sgpl1
Synonyms
AI428538; D10Xrf456; S1PL; Spl
Alternate Names
sphingosine-1-phosphate lyase 1; mSPL; SPL 1; SP-lyase 1; sphingosine-1-phosphate aldolase
Chromosome
10
Map Location
10 B4|10 32.14 cM
EC Number
4.1.2.27

Proteins

sphingosine-1-phosphate lyase 1
Refseq ID NP_033189
Protein GI 31543694
UniProt ID Q8R0X7
mRNA ID NM_009163
Length 568
RefSeq Status VALIDATED
MPGTDLLKLKDFEPYLEILESYSTKAKNYVNGYCTKYEPWQLIAWSVLCTLLIVWVYELIFQPESLWSRFKKKLFKLIRKMPFIGRKIEQQVSKAKKDLVKNMPFLKVDKDYVKTLPAQGMGTAEVLERLKEYSSMDGSWQEGKASGAVYNGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVALKKNMEVDVQAMKRAISRNTAMLVCSTPQFPHGVMDPVPEVAKLAVRYKIPLHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRTYQFFVGADWQGGVYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFIFGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSVFLDCLYTTDPVTQGNQMNGSPKPR

Gene Information

Entrez Gene ID
20397
Gene Name
sphingosine phosphate lyase 1
Gene Symbol
Sgpl1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016831 IEA:InterPro F carboxy-lyase activity
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0008117 ISS:UniProtKB F sphinganine-1-phosphate aldolase activity
GO:0033327 IMP:MGI P Leydig cell differentiation
GO:0008209 IMP:MGI P androgen metabolic process
GO:0097190 ISS:UniProtKB P apoptotic signaling pathway
GO:0006672 ISS:UniProtKB P ceramide metabolic process
GO:0008210 IMP:MGI P estrogen metabolic process
GO:0097194 IEA:Ensembl P execution phase of apoptosis
GO:0060325 IMP:MGI P face morphogenesis
GO:0006631 ISS:UniProtKB P fatty acid metabolic process
GO:0008585 IMP:MGI P female gonad development
GO:0010761 IMP:MGI P fibroblast migration
GO:0030097 IMP:MGI P hemopoiesis
GO:0001822 IMP:MGI P kidney development
GO:0001553 IMP:MGI P luteinization
GO:0006807 IMP:MGI P nitrogen compound metabolic process
GO:0060021 IMP:MGI P palate development
GO:0048008 IMP:MGI P platelet-derived growth factor receptor signaling pathway
GO:0009791 IMP:MGI P post-embryonic development
GO:0040014 IMP:MGI P regulation of multicellular organism growth
GO:0048705 IMP:MGI P skeletal system morphogenesis
GO:0007283 IMP:MGI P spermatogenesis
GO:0030149 ISS:UniProtKB P sphingolipid catabolic process
GO:0001570 IMP:MGI P vasculogenesis

KEGG Pathway Links

KEGG Pathway ID Description
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893777 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
sphingosine phosphate lyase 1
Protein Entry
SGPL1_MOUSE
UniProt ID
Q8R0X7
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO:0000269|PubMed:9464245}.
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:9464245}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.
Tissue Specificity Highest levels are found in liver, followed by kidney, lung, heart and brain. {ECO:0000269|PubMed:9464245}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001106 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31543694 RefSeq NP_033189 568 sphingosine-1-phosphate lyase 1

Identical Sequences to LMP001106 proteins

Reference Database Accession Length Protein Name
GI:31543694 GenBank EDL32157.1 568 sphingosine phosphate lyase 1, isoform CRA_b [Mus musculus]
GI:31543694 GenBank EDL32158.1 568 sphingosine phosphate lyase 1, isoform CRA_b [Mus musculus]
GI:31543694 GenBank EDL32159.1 568 sphingosine phosphate lyase 1, isoform CRA_b [Mus musculus]
GI:31543694 RefSeq XP_006513465.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Mus musculus]
GI:31543694 RefSeq XP_006513466.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X2 [Mus musculus]
GI:31543694 RefSeq XP_006513467.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X3 [Mus musculus]

Related Sequences to LMP001106 proteins

Reference Database Accession Length Protein Name
GI:31543694 DBBJ BAD32415.1 585 mKIAA1252 protein, partial [Mus musculus]
GI:31543694 EMBL CAJ18422.1 568 Sgpl1 [Mus musculus]
GI:31543694 EMBL CAM35393.1 568 unnamed protein product [Mus musculus]
GI:31543694 GenBank AAO94712.1 568 Sequence 2 from patent US 6495359
GI:31543694 GenBank AAQ32959.1 568 Sequence 6 from patent US 6569666
GI:31543694 GenBank AFD38196.1 568 Sequence 4 from patent US 8124111