Gene/Proteome Database (LMPD)

LMPD ID
LMP001103
Gene ID
69035
Species
Mus musculus (Mouse)
Gene Name
zinc finger, DHHC domain containing 3
Gene Symbol
Zdhhc3
Synonyms
1110020O22Rik; 1810006O10Rik; 2210017C02Rik; DHHC-3; GODZ; Gramp1; Zfp373
Alternate Names
palmitoyltransferase ZDHHC3; golgi-specific DHHC zinc finger protein; zinc finger DHHC domain-containing protein 3; GABA-A receptor-associated membrane protein 1
Chromosome
9
Map Location
9 F4|9
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC3
Refseq ID NP_081193
Protein GI 27754040
UniProt ID Q8R173
mRNA ID NM_026917
Length 299
RefSeq Status VALIDATED
MMLIPTHHFRDIERKPEYLQPEKCAPPPFPGPAGAMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLVPSRDYAYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLILLCFEALLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV

Gene Information

Entrez Gene ID
69035
Gene Name
zinc finger, DHHC domain containing 3
Gene Symbol
Zdhhc3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:MGI C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016409 IDA:MGI F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0018345 IDA:MGI P protein palmitoylation
GO:0006605 IDA:MGI P protein targeting

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC domain containing 3
Protein Entry
ZDHC3_MOUSE
UniProt ID
Q8R173
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity.
Function Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. {ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:15603741, ECO:0000269|PubMed:16129400}.
Ptm Autopalmitoylated.
Similarity Belongs to the DHHC palmitoyltransferase family. {ECO:0000305}.
Similarity Contains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:12163046, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:16129400}; Multi-pass membrane protein {ECO:0000269|PubMed:12163046, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:16129400}.
Tissue Specificity Widely expressed, with highest levels in brain. In the brain, expressed only in neurons (at protein level). {ECO:0000269|PubMed:12163046, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:15603741}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001103 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27754040 RefSeq NP_081193 299 palmitoyltransferase ZDHHC3

Identical Sequences to LMP001103 proteins

Reference Database Accession Length Protein Name
GI:27754040 DBBJ BAC02941.1 299 Golgi-specific DHHC zinc figer protein [Mus musculus]
GI:27754040 GenBank AAH25126.1 299 Zinc finger, DHHC domain containing 3 [Mus musculus]
GI:27754040 GenBank AAH52464.1 299 Zinc finger, DHHC domain containing 3 [Mus musculus]
GI:27754040 GenBank AAO27359.1 299 GABA-A receptor-associated membrane protein 1 [Mus musculus]
GI:27754040 GenBank EDL09080.1 299 zinc finger, DHHC domain containing 3, isoform CRA_h [Mus musculus]
GI:27754040 SwissProt Q8R173.1 299 RecName: Full=Palmitoyltransferase ZDHHC3; AltName: Full=GABA-A receptor-associated membrane protein 1; AltName: Full=Golgi-specific DHHC zinc finger protein; AltName: Full=Zinc finger DHHC domain-containing protein 3; Short=DHHC-3 [Mus musculus]

Related Sequences to LMP001103 proteins

Reference Database Accession Length Protein Name
GI:27754040 DBBJ BAC37939.1 299 unnamed protein product [Mus musculus]
GI:27754040 GenBank AAX73384.1 299 membrane-associated DHHC3 zinc finger protein [Rattus norvegicus]
GI:27754040 GenBank AAI28698.1 299 Zinc finger, DHHC-type containing 3 [Rattus norvegicus]
GI:27754040 GenBank EDL76770.1 299 rCG25574, isoform CRA_d [Rattus norvegicus]
GI:27754040 RefSeq NP_001034103.1 299 palmitoyltransferase ZDHHC3 [Rattus norvegicus]
GI:27754040 RefSeq XP_006244250.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform X1 [Rattus norvegicus]