Gene/Proteome Database (LMPD)

LMPD ID
LMP001071
Gene ID
225326
Species
Mus musculus (Mouse)
Gene Name
phosphoinositide-3-kinase, class 3
Gene Symbol
Pik3c3
Synonyms
5330434F23Rik; Vps34
Alternate Names
phosphatidylinositol 3-kinase catalytic subunit type 3; PI3K type 3; PI3-kinase type 3; ptdIns-3-kinase type 3
Chromosome
18
Map Location
18 B1|18
EC Number
2.7.1.137

Proteins

phosphatidylinositol 3-kinase catalytic subunit type 3
Refseq ID NP_852079
Protein GI 42475974
UniProt ID Q6PF93
mRNA ID NM_181414
Length 887
RefSeq Status PROVISIONAL
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGSAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQTSASESLSNSGVSSGDIDSSQIITNPLPPVASPPPASKAKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK

Gene Information

Entrez Gene ID
225326
Gene Name
phosphoinositide-3-kinase, class 3
Gene Symbol
Pik3c3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005770 ISS:UniProtKB C late endosome
GO:0030496 ISS:UniProtKB C midbody
GO:0045335 IDA:MGI C phagocytic vesicle
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0016303 ISS:UniProtKB F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004672 IMP:MGI F protein kinase activity
GO:0000045 IEA:Ensembl P autophagic vacuole assembly
GO:0000910 ISS:UniProtKB P cytokinesis
GO:0045022 ISS:UniProtKB P early endosome to late endosome transport
GO:0007032 IEA:Ensembl P endosome organization
GO:0036092 IBA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:Ensembl P phosphatidylinositol-mediated signaling
GO:0006468 IMP:MGI P protein phosphorylation
GO:0016485 IEA:Ensembl P protein processing
GO:0050708 IEA:Ensembl P regulation of protein secretion
GO:0043201 IEA:Ensembl P response to leucine

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism
mmu04145 Phagosome
mmu04140 Regulation of autophagy
mmu05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, class 3
Protein Entry
PK3C3_MOUSE
UniProt ID
Q6PF93
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PF93-1; Sequence=Displayed; Name=2; IsoId=Q6PF93-2; Sequence=VSP_016459, VSP_016460; Note=No experimental confirmation available.;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes (By similarity). {ECO:0000250}.
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00880}.
Similarity Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Midbody {ECO:0000250}. Late endosome {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000269|PubMed:24089209}.
Subunit Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4 (By similarity). Interacts with AMBRA1. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive (By similarity). Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN1P1/BECN2 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001071 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42475974 RefSeq NP_852079 887 phosphatidylinositol 3-kinase catalytic subunit type 3

Identical Sequences to LMP001071 proteins

Reference Database Accession Length Protein Name
GI:42475974 GenBank AAH57678.1 887 Phosphoinositide-3-kinase, class 3 [Mus musculus]
GI:42475974 GenBank EDK97021.1 887 phosphoinositide-3-kinase, class 3, isoform CRA_a [Mus musculus]
GI:42475974 RefSeq XP_006525902.1 887 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [Mus musculus]
GI:42475974 SwissProt Q6PF93.1 887 RecName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3; Short=PI3-kinase type 3; Short=PI3K type 3; Short=PtdIns-3-kinase type 3; AltName: Full=Phosphoinositide-3-kinase class 3 [Mus musculus]

Related Sequences to LMP001071 proteins

Reference Database Accession Length Protein Name
GI:42475974 EMBL CAA07199.1 887 phosphatidylinositol 3-kinase [Rattus norvegicus]
GI:42475974 GenBank AAH61981.1 887 Phosphoinositide-3-kinase, class 3 [Rattus norvegicus]
GI:42475974 GenBank EDL76162.1 887 phosphoinositide-3-kinase, class 3 [Rattus norvegicus]
GI:42475974 RefSeq NP_075247.1 887 phosphatidylinositol 3-kinase catalytic subunit type 3 [Rattus norvegicus]
GI:42475974 RefSeq XP_005355906.1 887 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3-like [Microtus ochrogaster]
GI:42475974 SwissProt O88763.1 887 RecName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3; Short=PI3-kinase type 3; Short=PI3K type 3; Short=PtdIns-3-kinase type 3; AltName: Full=Phosphoinositide-3-kinase class 3 [Rattus norvegicus]