Gene/Proteome Database (LMPD)

LMPD ID
LMP001057
Gene ID
16987
Species
Mus musculus (Mouse)
Gene Name
lanosterol synthase
Gene Symbol
Lss
Synonyms
2810025N20Rik; BC029082; D10Ertd116e; Osc
Chromosome
10
Map Location
10 C1|10 39.1 cM

Proteins

lanosterol synthase
Refseq ID NP_666118
Protein GI 22122469
UniProt ID Q8BLN5
mRNA ID NM_146006
Length 733
RefSeq Status PROVISIONAL
MTEGTCLRRRGGPYKTEPATDLTRWRLQNELGRQRWTYYQAEDDPGREQTGLEAHSLGLDTRSYFTDLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAACAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRFSNLYPDNTLAGHI

Gene Information

Entrez Gene ID
16987
Gene Name
lanosterol synthase
Gene Symbol
Lss
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005811 IEA:Ensembl C lipid particle
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0000250 IEA:UniProtKB-EC F lanosterol synthase activity
GO:0006695 IEA:Ensembl P cholesterol biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR018333 Squalene cyclase
IPR002365 Terpene synthase, conserved site
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
lanosterol synthase
Protein Entry
Q8BLN5_MOUSE
UniProt ID
Q8BLN5
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
Function Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.
Similarity Belongs to the terpene cyclase/mutase family.
Similarity Contains 4 PFTB repeats.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein .
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP001057 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22122469 RefSeq NP_666118 733 lanosterol synthase

Identical Sequences to LMP001057 proteins

Reference Database Accession Length Protein Name
GI:22122469 EMBL CBG17649.1 733 unnamed protein product [Mus musculus]
GI:22122469 EMBL CBG17741.1 733 unnamed protein product [Mus musculus]
GI:22122469 EMBL CBV31003.1 733 unnamed protein product [Mus musculus]
GI:22122469 EMBL CBV31096.1 733 unnamed protein product [Mus musculus]
GI:22122469 GenBank AGY09258.1 733 Sequence 98638 from patent US 8541208
GI:22122469 GenBank AGY09364.1 733 Sequence 98841 from patent US 8541208

Related Sequences to LMP001057 proteins

Reference Database Accession Length Protein Name
GI:22122469 DBBJ BAC31739.1 733 unnamed protein product [Mus musculus]
GI:22122469 DBBJ BAC37102.1 733 unnamed protein product [Mus musculus]
GI:22122469 EMBL CBG17621.1 733 unnamed protein product [Rattus norvegicus]
GI:22122469 EMBL CBG17713.1 733 unnamed protein product [Rattus norvegicus]
GI:22122469 GenBank AAA91023.1 733 oxidosqualene cyclase [Rattus norvegicus]
GI:22122469 RefSeq XP_006992607.1 733 PREDICTED: lanosterol synthase [Peromyscus maniculatus bairdii]