Gene/Proteome Database (LMPD)

LMPD ID
LMP000995
Gene ID
52538
Species
Mus musculus (Mouse)
Gene Name
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Gene Symbol
Acaa2
Synonyms
0610011L04Rik; AI255831; AI265397; D18Ertd240e
Alternate Names
3-ketoacyl-CoA thiolase, mitochondrial; beta-ketothiolase; acetyl-CoA acyltransferase; mitochondrial 3-oxoacyl-CoA thiolase
Chromosome
18
Map Location
18 E2|18 50.76 cM
EC Number
2.3.1.16

Proteins

3-ketoacyl-CoA thiolase, mitochondrial
Refseq ID NP_803421
Protein GI 29126205
UniProt ID Q8BWT1
mRNA ID NM_177470
Length 397
RefSeq Status PROVISIONAL
MALLRGVFIVAAKRTPFGAYGGLLKDFSATDLTEFAARAALSAGKVPPETIDSVIVGNVMQSSSDAAYLARHVGLRVGVPTETGALTLNRLCGSGFQSIVSGCQEICSKDAEVVLCGGTESMSQSPYCVRNVRFGTKFGLDLKLEDTLWAGLTDQHVKLPMGMTAENLAAKYNISREDCDRYALQSQQRWKAANEAGYFNEEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPSVFKKDGTVTAGNASGVSDGAGAVIIASEDAVKKHNFTPLARVVGYFVSGCDPTIMGIGPVPAINGALKKAGLSLKDMDLIDVNEAFAPQFLSVQKALDLDPSKTNVSGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIALIIQNTA
transit_peptide: 1..16 inference: non-experimental evidence, no additional details recorded note: Mitochondrion, not cleaved (By similarity); propagated from UniProtKB/Swiss-Prot (Q8BWT1.3) calculated_mol_wt: 1743 peptide sequence: MALLRGVFIVAAKRTP

Gene Information

Entrez Gene ID
52538
Gene Name
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Gene Symbol
Acaa2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0003988 IEA:UniProtKB-EC F acetyl-CoA C-acyltransferase activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0071456 IEA:Ensembl P cellular response to hypoxia
GO:0006631 IEA:UniProtKB-UniPathway P fatty acid metabolic process
GO:1902109 IEA:Ensembl P negative regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1901029 ISS:UniProtKB P negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
mmu00071 Fatty acid degradation
mmu00062 Fatty acid elongation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Protein Entry
THIM_MOUSE
UniProt ID
Q8BWT1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Function Abolishes BNIP3-mediated apoptosis and mitochondrial damage. {ECO:0000250}.
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}. Note=Colocalizes with BNIP3 in the mitochondria. {ECO:0000250}.
Subunit Homotetramer. Interacts with BNIP3 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000995 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
29126205 RefSeq NP_803421 397 3-ketoacyl-CoA thiolase, mitochondrial

Identical Sequences to LMP000995 proteins

Reference Database Accession Length Protein Name
GI:29126205 DBBJ BAC34067.1 397 unnamed protein product [Mus musculus]
GI:29126205 DBBJ BAE41108.1 397 unnamed protein product [Mus musculus]
GI:29126205 DBBJ BAE39630.1 397 unnamed protein product [Mus musculus]
GI:29126205 DBBJ BAE39757.1 397 unnamed protein product [Mus musculus]
GI:29126205 GenBank EDL09521.1 397 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_k [Mus musculus]
GI:29126205 SwissProt Q8BWT1.3 397 RecName: Full=3-ketoacyl-CoA thiolase, mitochondrial; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Beta-ketothiolase; AltName: Full=Mitochondrial 3-oxoacyl-CoA thiolase [Mus musculus]

Related Sequences to LMP000995 proteins

Reference Database Accession Length Protein Name
GI:29126205 DBBJ BAE26828.1 397 unnamed protein product [Mus musculus]
GI:29126205 EMBL CAA28952.1 397 unnamed protein product [Rattus norvegicus]
GI:29126205 GenBank AAH28901.1 397 Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) [Mus musculus]
GI:29126205 GenBank EDL82880.1 397 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_f [Rattus norvegicus]
GI:29126205 RefSeq NP_569117.1 397 3-ketoacyl-CoA thiolase, mitochondrial [Rattus norvegicus]
GI:29126205 SwissProt P13437.1 397 RecName: Full=3-ketoacyl-CoA thiolase, mitochondrial; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Beta-ketothiolase; AltName: Full=Mitochondrial 3-oxoacyl-CoA thiolase [Rattus norvegicus]