Gene/Proteome Database (LMPD)

LMPD ID
LMP000901
Gene ID
18777
Species
Mus musculus (Mouse)
Gene Name
lysophospholipase 1
Gene Symbol
Lypla1
Synonyms
Pla1a
Alternate Names
acyl-protein thioesterase 1; APT-1; LPL-I; lysoPLA I; phospholipase 1a; lysophopholipase 1; lysophospholipase I
Chromosome
1
Map Location
1 A1|1
EC Number
3.1.2.-

Proteins

acyl-protein thioesterase 1
Refseq ID NP_032892
Protein GI 6678760
UniProt ID P97823
mRNA ID NM_008866
Length 230
RefSeq Status PROVISIONAL
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSPHIKYICPHAPVMPVTLNMNMAMPSWFDIVGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKALINPANVTFKIYEGMMHSSCQQEMMDVKHFIDKLLPPID

Gene Information

Entrez Gene ID
18777
Gene Name
lysophospholipase 1
Gene Symbol
Lypla1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:MGI C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0008474 ISS:UniProtKB F palmitoyl-(protein) hydrolase activity
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0042997 IMP:MGI P negative regulation of Golgi to plasma membrane protein transport
GO:0002084 IMP:MGI P protein depalmitoylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
mmu00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893542 eNOS activation
5893543 eNOS activation and regulation

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003140 Phospholipase/carboxylesterase/thioesterase

UniProt Annotations

Entry Information

Gene Name
lysophospholipase 1
Protein Entry
LYPA1_MOUSE
UniProt ID
P97823
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97823-1; Sequence=Displayed; Name=2; IsoId=P97823-2; Sequence=VSP_009197; Note=May be due to an intron retention. No experimental confirmation available.;
Catalytic Activity Palmitoyl-protein + H(2)O = palmitate + protein.
Function Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity). {ECO:0000250}.
Sequence Caution Sequence=BAC34318.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000901 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6678760 RefSeq NP_032892 230 acyl-protein thioesterase 1

Identical Sequences to LMP000901 proteins

Reference Database Accession Length Protein Name
GI:6678760 DBBJ BAE27497.1 230 unnamed protein product [Mus musculus]
GI:6678760 DBBJ BAE39355.1 230 unnamed protein product [Mus musculus]
GI:6678760 GenBank EDL14248.1 230 lysophospholipase 1, isoform CRA_a [Mus musculus]
GI:6678760 GenBank AEU43366.1 230 Sequence 115 from patent US 8052970
GI:6678760 RefSeq NP_001103287.1 230 acyl-protein thioesterase 1 [Oryctolagus cuniculus]
GI:6678760 SwissProt P97823.1 230 RecName: Full=Acyl-protein thioesterase 1; Short=APT-1; AltName: Full=Lysophospholipase 1; AltName: Full=Lysophospholipase I; Short=LPL-I; Short=LysoPLA I [Mus musculus]

Related Sequences to LMP000901 proteins

Reference Database Accession Length Protein Name
GI:6678760 EMBL CAJ18409.1 230 Lypla1 [Mus musculus]
GI:6678760 GenBank AAE01610.1 230 Sequence 3 from patent US 5858756
GI:6678760 GenBank AAE30798.1 230 Sequence 5 from patent US 5965423
GI:6678760 GenBank AAE41537.1 230 Sequence 3 from patent US 6004792
GI:6678760 GenBank AAH52848.1 230 Lysophospholipase 1 [Mus musculus]
GI:6678760 RefSeq NP_037138.1 230 acyl-protein thioesterase 1 [Rattus norvegicus]