Gene/Proteome Database (LMPD)

LMPD ID
LMP000865
Gene ID
18803
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, gamma 1
Gene Symbol
Plcg1
Synonyms
AI894140; Cded; Plc-1; Plc-gamma1; Plcg-1
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-gamma-1; phospholipase C-gamma-1; phosphoinositide phospholipase C-gamma-1; cell differentiation and embryonic development; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Chromosome
2
Map Location
2 H2|2 80.97 cM
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Refseq ID NP_067255
Protein GI 41393059
UniProt ID Q62077
mRNA ID NM_021280
Length 1302
RefSeq Status PROVISIONAL
MAGVATPCANGCGPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNALRTGERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLRRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERSTSDGPSSATNLIEDPLHDKLWKCSL

Gene Information

Entrez Gene ID
18803
Gene Name
phospholipase C, gamma 1
Gene Symbol
Plcg1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008180 IEA:Ensembl C COP9 signalosome
GO:0005911 IDA:MGI C cell-cell junction
GO:0005737 ISO:MGI C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0030027 ISS:UniProtKB C lamellipodium
GO:0005886 IEA:Ensembl C plasma membrane
GO:0001726 ISS:UniProtKB C ruffle
GO:0005509 IEA:InterPro F calcium ion binding
GO:0035254 IPI:MGI F glutamate receptor binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0030971 IPI:UniProtKB F receptor tyrosine kinase binding
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0050852 IDA:MGI P T cell receptor signaling pathway
GO:0019722 IEA:Ensembl P calcium-mediated signaling
GO:0016477 IEA:Ensembl P cell migration
GO:0071364 ISS:UniProtKB P cellular response to epidermal growth factor stimulus
GO:0007173 IEA:Ensembl P epidermal growth factor receptor signaling pathway
GO:0001701 IMP:MGI P in utero embryonic development
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0043536 IEA:Ensembl P positive regulation of blood vessel endothelial cell migration
GO:0010634 ISS:UniProtKB P positive regulation of epithelial cell migration
GO:0051281 IEA:Ensembl P positive regulation of release of sequestered calcium ion into cytosol

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04015 Rap1 signaling pathway
mmu04014 Ras signaling pathway
mmu04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028380 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR000980 SH2 domain
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, gamma 1
Protein Entry
PLCG1_MOUSE
UniProt ID
Q62077
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Domain The SH3 domain mediates interaction with RALGPS1 (By similarity). The SH3 domain also mediates interaction with CLNK. {ECO:0000250, ECO:0000269|PubMed:11463797}.
Enzyme Regulation Activated by phosphorylation on tyrosine residues.
Function Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:15308098}.
Interaction P14753:Epor; NbExp=4; IntAct=EBI-300133, EBI-617901; Q60631:Grb2; NbExp=2; IntAct=EBI-300133, EBI-1688; O54957:Lat; NbExp=2; IntAct=EBI-300133, EBI-6390034; P48356:Lepr; NbExp=2; IntAct=EBI-300133, EBI-2257257;
Ptm Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. May be dephosphorylated by PTPRJ (By similarity). {ECO:0000250}.
Ptm Ubiquitinated by CBLB in activated T-cells. {ECO:0000269|PubMed:15308098}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Similarity Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Similarity Contains 2 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular Location Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000250}.
Subunit Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with RALGPS1. Interacts (via SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with RET (By similarity). Interacts with AGAP2 via its SH3 domain. Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK. Interacts with FLT4 and KIT. Interacts with AXL (By similarity). Interacts with SYK; activates PLCG1 (By similarity). Interacts with FLT1 (tyrosine-phosphorylated). Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C. Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with TESPA1 (By similarity). Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1. {ECO:0000250, ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10748127, ECO:0000269|PubMed:11463797, ECO:0000269|PubMed:12367511, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16000869, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:1714377, ECO:0000269|PubMed:17620338, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:22561606, ECO:0000269|PubMed:8943348, ECO:0000269|PubMed:9299537}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000865 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41393059 RefSeq NP_067255 1302 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Identical Sequences to LMP000865 proteins

Reference Database Accession Length Protein Name
GI:41393059 EMBL CBF74731.1 1302 unnamed protein product [Mus musculus]
GI:41393059 EMBL CBF62965.1 1302 unnamed protein product [Mus musculus]
GI:41393059 EMBL CBU87841.1 1302 unnamed protein product [Mus musculus]
GI:41393059 EMBL CBU96788.1 1302 unnamed protein product [Mus musculus]
GI:41393059 GenBank AGX54776.1 1302 Sequence 9908 from patent US 8541208
GI:41393059 GenBank AGX64216.1 1302 Sequence 28542 from patent US 8541208

Related Sequences to LMP000865 proteins

Reference Database Accession Length Protein Name
GI:41393059 GenBank AAA41921.1 1290 phospholipase C [Rattus norvegicus]
GI:41393059 GenBank ABK42331.1 1290 phospholipase C-gamma1 [synthetic construct]
GI:41393059 GenBank EDL06292.1 1290 phospholipase C, gamma 1, isoform CRA_c [Mus musculus]
GI:41393059 GenBank EDL96614.1 1286 phospholipase C, gamma 1, isoform CRA_a [Rattus norvegicus]
GI:41393059 GenBank EDL96615.1 1290 phospholipase C, gamma 1, isoform CRA_b [Rattus norvegicus]
GI:41393059 SwissProt P10686.1 1290 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; AltName: Full=Phosphoinositide phospholipase C-gamma-1; AltName: Full=Phospholipase C-gamma-1; Short=PLC-gamma-1 [Rattus norvegicus]