Gene/Proteome Database (LMPD)

LMPD ID
LMP000825
Gene ID
16976
Species
Mus musculus (Mouse)
Gene Name
low density lipoprotein receptor-related protein associated protein 1
Gene Symbol
Lrpap1
Synonyms
AA617339; AI790446; AU042172; C77774; HBP44; RAP
Alternate Names
alpha-2-macroglobulin receptor-associated protein; HBP-44; alpha-2-MRAP; heparin-binding protein 44; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein receptor related protein, associated protein 1; Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44)
Chromosome
5
Map Location
5 B2|5 18.01 cM

Proteins

alpha-2-macroglobulin receptor-associated protein precursor
Refseq ID NP_038615
Protein GI 63999380
UniProt ID P55302
mRNA ID NM_013587
Length 360
RefSeq Status PROVISIONAL
MAPRRERVSTLPRLQLLVLLLLPLMLVPQPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL
sig_peptide: 1..28 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (P55302.1) calculated_mol_wt: 3239 peptide sequence: MAPRRERVSTLPRLQLLVLLLLPLMLVP mat_peptide: 29..360 product: Alpha-2-macroglobulin receptor-associated protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P55302.1) calculated_mol_wt: 38994 peptide sequence: QPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL

Gene Information

Entrez Gene ID
16976
Gene Name
low density lipoprotein receptor-related protein associated protein 1
Gene Symbol
Lrpap1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:Ensembl C extracellular region
GO:0005886 ISO:MGI C plasma membrane
GO:0048237 IEA:Ensembl C rough endoplasmic reticulum lumen
GO:0031982 IEA:Ensembl C vesicle
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0050750 IPI:MGI F low-density lipoprotein particle receptor binding
GO:1900116 IEA:Ensembl P extracellular negative regulation of signal transduction
GO:1900222 IEA:Ensembl P negative regulation of beta-amyloid clearance
GO:0032091 IEA:Ensembl P negative regulation of protein binding
GO:0010916 IEA:Ensembl P negative regulation of very-low-density lipoprotein particle clearance

Domain Information

InterPro Annotations

Accession Description
IPR010483 Alpha-2-macroglobulin RAP, C-terminal
IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1

UniProt Annotations

Entry Information

Gene Name
low density lipoprotein receptor-related protein associated protein 1
Protein Entry
AMRP_MOUSE
UniProt ID
P55302
Species
Mouse

Comments

Comment Type Description
Function Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Similarity Belongs to the alpha-2-MRAP family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138}. Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum (By similarity). {ECO:0000250}.
Subunit Present on cell surface forming a complex with the alpha- 2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells. {ECO:0000269|PubMed:2229028}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000825 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
63999380 RefSeq NP_038615 360 alpha-2-macroglobulin receptor-associated protein precursor

Identical Sequences to LMP000825 proteins

Reference Database Accession Length Protein Name
GI:63999380 DBBJ BAE40911.1 360 unnamed protein product [Mus musculus]
GI:63999380 DBBJ BAE42477.1 360 unnamed protein product [Mus musculus]
GI:63999380 DBBJ BAE38988.1 360 unnamed protein product [Mus musculus]
GI:63999380 DBBJ BAE39045.1 360 unnamed protein product [Mus musculus]
GI:63999380 DBBJ BAE26604.1 360 unnamed protein product [Mus musculus]
GI:63999380 GenBank EDL37476.1 360 low density lipoprotein receptor-related protein associated protein 1, isoform CRA_a [Mus musculus]

Related Sequences to LMP000825 proteins

Reference Database Accession Length Protein Name
GI:63999380 DBBJ BAA00500.1 359 heparin binding protein 44, partial [Mus musculus]
GI:63999380 EMBL CAG25840.1 360 low density lipoprotein receptor-associated protein 1 [Mus musculus]
GI:63999380 GenBank AAH46641.1 359 Lrpap1 protein, partial [Mus musculus]
GI:63999380 GenBank ACW21604.1 378 Sequence 22 from patent US 7560431
GI:63999380 GenBank ACW32615.1 378 Sequence 22 from patent US 7569544
GI:63999380 GenBank ADS96648.1 378 Sequence 22 from patent US 7829537