Gene/Proteome Database (LMPD)

LMPD ID
LMP000720
Gene ID
8526
Species
Homo sapiens (Human)
Gene Name
diacylglycerol kinase, epsilon 64kDa
Gene Symbol
DGKE
Synonyms
DAGK5; DAGK6; DGK; NPHS7
Chromosome
17
Map Location
17q22
EC Number
2.7.1.107
Summary
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for DGKE

Proteins

diacylglycerol kinase epsilon
Refseq ID NP_003638
Protein GI 4503313
UniProt ID P52429
mRNA ID NM_003647
Length 567
RefSeq Status REVIEWED
MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMMLYFSGEQTDDDISSTSDQEDIKATE

Gene Information

Entrez Gene ID
8526
Gene Name
diacylglycerol kinase, epsilon 64kDa
Gene Symbol
DGKE
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
hsa00564 Glycerophospholipid metabolism
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19184 GPCR downstream signaling

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, epsilon 64kDa
Protein Entry
DGKE_HUMAN
UniProt ID
P52429
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Similarity Belongs to the eukaryotic diacylglycerol kinase family.
Similarity Contains 1 DAGKc domain.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers.

Identical and Related Proteins

Unique RefSeq proteins for LMP000720 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4503313 RefSeq NP_003638 567 diacylglycerol kinase epsilon

Identical Sequences to LMP000720 proteins

Reference Database Accession Length Protein Name
GI:4503313 DBBJ BAF85728.1 567 unnamed protein product [Homo sapiens]
GI:4503313 GenBank EAW94526.1 567 diacylglycerol kinase, epsilon 64kDa [Homo sapiens]
GI:4503313 GenBank AAI30630.1 567 Diacylglycerol kinase, epsilon 64kDa [Homo sapiens]
GI:4503313 GenBank AAI30632.1 567 Diacylglycerol kinase, epsilon 64kDa [Homo sapiens]
GI:4503313 GenBank ADR83069.1 567 diacylglycerol kinase, epsilon 64kDa, partial [synthetic construct]
GI:4503313 GenBank AIC63215.1 567 DGKE, partial [synthetic construct]

Related Sequences to LMP000720 proteins

Reference Database Accession Length Protein Name
GI:4503313 GenBank AFE65715.1 567 diacylglycerol kinase epsilon [Macaca mulatta]
GI:4503313 GenBank AFH30371.1 567 diacylglycerol kinase epsilon [Macaca mulatta]
GI:4503313 GenBank JAA07473.1 567 diacylglycerol kinase, epsilon 64kDa [Pan troglodytes]
GI:4503313 GenBank JAA15353.1 567 diacylglycerol kinase, epsilon 64kDa [Pan troglodytes]
GI:4503313 RefSeq XP_001171847.2 567 PREDICTED: diacylglycerol kinase epsilon isoform X2 [Pan troglodytes]
GI:4503313 RefSeq XP_003817456.1 567 PREDICTED: diacylglycerol kinase epsilon isoform X2 [Pan paniscus]