Gene/Proteome Database (LMPD)

LMPD ID
LMP000626
Gene ID
12306
Species
Mus musculus (Mouse)
Gene Name
annexin A2
Gene Symbol
Anxa2
Synonyms
AW215814; Cal1h
Alternate Names
annexin A2; p36; PAP-IV; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; 33-kDa calcimedin; 36-kDa calelectrin; calpactin I heavy chain; calpactin-1 heavy chain; placental anticoagulant protein IV; 33kDa lymphocyte Ca<2+>- binding protein; 33-kDa lymphocyte Ca<2+>- binding protein
Chromosome
9
Map Location
9 C|9 38.58 cM

Proteins

annexin A2
Refseq ID NP_031611
Protein GI 6996913
UniProt ID P07356
mRNA ID NM_007585
Length 339
RefSeq Status PROVISIONAL
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Gene Information

Entrez Gene ID
12306
Gene Name
annexin A2
Gene Symbol
Anxa2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043220 IDA:BHF-UCL C Schmidt-Lanterman incisure
GO:0005604 IEA:UniProtKB-KW C basement membrane
GO:0005938 IEA:Ensembl C cell cortex
GO:0009986 IEA:Ensembl C cell surface
GO:0005737 IDA:MGI C cytoplasm
GO:0005769 IDA:MGI C early endosome
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0019897 IDA:MGI C extrinsic component of plasma membrane
GO:0031902 IEA:Ensembl C late endosome membrane
GO:0005811 IEA:Ensembl C lipid particle
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0044354 IEA:Ensembl C macropinosome
GO:0045121 IEA:Ensembl C membrane raft
GO:0030496 IEA:Ensembl C midbody
GO:0035749 IDA:BHF-UCL C myelin sheath adaxonal region
GO:0005634 IEA:Ensembl C nucleus
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0043234 IEA:Ensembl C protein complex
GO:0001726 IEA:Ensembl C ruffle
GO:0042383 IDA:MGI C sarcolemma
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005544 IEA:UniProtKB-KW F calcium-dependent phospholipid binding
GO:0005546 IEA:Ensembl F phosphatidylinositol-4,5-bisphosphate binding
GO:0019834 IEA:Ensembl F phospholipase A2 inhibitor activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0001525 IMP:MGI P angiogenesis
GO:0007589 IEA:Ensembl P body fluid secretion
GO:0030199 IMP:MGI P collagen fibril organization
GO:0042730 IMP:MGI P fibrinolysis
GO:0006900 IEA:Ensembl P membrane budding
GO:0001765 IEA:Ensembl P membrane raft assembly
GO:0036035 IEA:Ensembl P osteoclast development
GO:0051099 IMP:MGI P positive regulation of binding
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0031340 IEA:Ensembl P positive regulation of vesicle fusion
GO:0051290 IEA:Ensembl P protein heterotetramerization
GO:0072661 IEA:Ensembl P protein targeting to plasma membrane

REACTOME Pathway Links

REACTOME Pathway ID Description
5893225 Dissolution of Fibrin Clot
5893155 Hemostasis

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR002389 Annexin, type II
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A2
Protein Entry
ANXA2_MOUSE
UniProt ID
P07356
Species
Mouse

Comments

Comment Type Description
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Interaction P08207:S100a10; NbExp=2; IntAct=EBI-738510, EBI-643986;
Miscellaneous It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Ptm ISGylated. {ECO:0000269|PubMed:16139798}.
Similarity Belongs to the annexin family. {ECO:0000305}.
Similarity Contains 4 annexin repeats. {ECO:0000305}.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane.
Subunit Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF. Interacts with ATP1B1 (By similarity). Interacts with COCH (By similarity). {ECO:0000250}.
Web Resource Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";

Identical and Related Proteins

Unique RefSeq proteins for LMP000626 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6996913 RefSeq NP_031611 339 annexin A2

Identical Sequences to LMP000626 proteins

Reference Database Accession Length Protein Name
GI:6996913 GenBank AGA52077.1 339 Sequence 12 from patent US 8329410
GI:6996913 PDB 4HRE 339 Chain A, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 PDB 4HRE 339 Chain C, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 PDB 4HRE 339 Chain B, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 PDB 4HRE 339 Chain D, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 RefSeq XP_006510859.1 339 PREDICTED: annexin A2 isoform X1 [Mus musculus]

Related Sequences to LMP000626 proteins

Reference Database Accession Length Protein Name
GI:6996913 DBBJ BAE29680.1 339 unnamed protein product [Mus musculus]
GI:6996913 RefSeq XP_005075540.1 339 PREDICTED: annexin A2 [Mesocricetus auratus]
GI:6996913 RefSeq XP_005347735.1 339 PREDICTED: annexin A2 [Microtus ochrogaster]
GI:6996913 RefSeq XP_006979351.1 339 PREDICTED: annexin A2 isoform X1 [Peromyscus maniculatus bairdii]
GI:6996913 RefSeq XP_006979352.1 339 PREDICTED: annexin A2 isoform X2 [Peromyscus maniculatus bairdii]
GI:6996913 RefSeq XP_007608088.1 339 PREDICTED: annexin A2 isoform X2 [Cricetulus griseus]