Gene/Proteome Database (LMPD)

LMPD ID
LMP000560
Gene ID
20851
Species
Mus musculus (Mouse)
Gene Name
signal transducer and activator of transcription 5B
Gene Symbol
Stat5b
Synonyms
-
Alternate Names
signal transducer and activator of transcription 5B; mammary gland factor STAT5B
Chromosome
11
Map Location
11 D|11 63.63 cM

Proteins

signal transducer and activator of transcription 5B
Refseq ID NP_035619
Protein GI 165932366
UniProt ID P42232
mRNA ID NM_011489
Length 786
RefSeq Status VALIDATED
MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGSGATYMDQAPSPVVCPQAHYNMYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
signal transducer and activator of transcription 5B
Refseq ID NP_001107035
Protein GI 165932368
UniProt ID P42232
mRNA ID NM_001113563
Length 786
RefSeq Status VALIDATED
Protein sequence is identical to GI:165932366 (mRNA isoform)

Gene Information

Entrez Gene ID
20851
Gene Name
signal transducer and activator of transcription 5B
Gene Symbol
Stat5b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:UniProtKB C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0000979 IDA:MGI F RNA polymerase II core promoter sequence-specific DNA binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0003682 ISS:UniProtKB F chromatin binding
GO:0003690 IEA:Ensembl F double-stranded DNA binding
GO:0046983 IDA:UniProtKB F protein dimerization activity
GO:0019903 IPI:UniProtKB F protein phosphatase binding
GO:0003700 IEA:Ensembl F sequence-specific DNA binding transcription factor activity
GO:0004871 IGI:MGI F signal transducer activity
GO:0006103 IMP:BHF-UCL P 2-oxoglutarate metabolic process
GO:0007259 IDA:MGI P JAK-STAT cascade
GO:0060397 IDA:BHF-UCL P JAK-STAT cascade involved in growth hormone signaling pathway
GO:0048541 IGI:MGI P Peyer's patch development
GO:0033077 IGI:MGI P T cell differentiation in thymus
GO:0043029 IGI:MGI P T cell homeostasis
GO:0006953 IEA:Ensembl P acute-phase response
GO:0000255 IMP:BHF-UCL P allantoin metabolic process
GO:0071364 ISS:UniProtKB P cellular response to epidermal growth factor stimulus
GO:0071363 IDA:UniProtKB P cellular response to growth factor stimulus
GO:0006101 IMP:BHF-UCL P citrate metabolic process
GO:0006600 IMP:BHF-UCL P creatine metabolic process
GO:0046449 IMP:BHF-UCL P creatinine metabolic process
GO:0019221 IDA:MGI P cytokine-mediated signaling pathway
GO:0046543 IMP:MGI P development of secondary female sexual characteristics
GO:0046544 IMP:MGI P development of secondary male sexual characteristics
GO:0006631 IMP:BHF-UCL P fatty acid metabolic process
GO:0007565 IMP:MGI P female pregnancy
GO:0006549 IMP:BHF-UCL P isoleucine metabolic process
GO:0007595 IMP:MGI P lactation
GO:0019915 IGI:MGI P lipid storage
GO:0001889 IEA:Ensembl P liver development
GO:0001553 IGI:MGI P luteinization
GO:0001779 IGI:MGI P natural killer cell differentiation
GO:0043066 IGI:MGI P negative regulation of apoptotic process
GO:0045647 IGI:MGI P negative regulation of erythrocyte differentiation
GO:0006107 IMP:BHF-UCL P oxaloacetate metabolic process
GO:0045579 IGI:MGI P positive regulation of B cell differentiation
GO:0042104 IMP:MGI P positive regulation of activated T cell proliferation
GO:0008284 IGI:MGI P positive regulation of cell proliferation
GO:0051272 IEA:Ensembl P positive regulation of cellular component movement
GO:0045588 IGI:MGI P positive regulation of gamma-delta T cell differentiation
GO:0050729 IGI:MGI P positive regulation of inflammatory response
GO:0045086 IGI:MGI P positive regulation of interleukin-2 biosynthetic process
GO:0045621 IGI:MGI P positive regulation of lymphocyte differentiation
GO:0045931 IGI:MGI P positive regulation of mitotic cell cycle
GO:0040018 IMP:MGI P positive regulation of multicellular organism growth
GO:0032825 IMP:MGI P positive regulation of natural killer cell differentiation
GO:0045954 IMP:MGI P positive regulation of natural killer cell mediated cytotoxicity
GO:0032819 IMP:MGI P positive regulation of natural killer cell proliferation
GO:0048661 IEA:Ensembl P positive regulation of smooth muscle cell proliferation
GO:0045944 IDA:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0042448 IGI:MGI P progesterone metabolic process
GO:0038161 IDA:UniProtKB P prolactin signaling pathway
GO:0030155 IMP:MGI P regulation of cell adhesion
GO:0030856 IMP:MGI P regulation of epithelial cell differentiation
GO:0040014 IDA:BHF-UCL P regulation of multicellular organism growth
GO:0019218 IGI:MGI P regulation of steroid metabolic process
GO:0006357 IGI:MGI P regulation of transcription from RNA polymerase II promoter
GO:0032355 IEA:Ensembl P response to estradiol
GO:0045471 IEA:Ensembl P response to ethanol
GO:0001666 IEA:Ensembl P response to hypoxia
GO:0070672 IMP:MGI P response to interleukin-15
GO:0070669 IMP:MGI P response to interleukin-2
GO:0070670 IMP:MGI P response to interleukin-4
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0007548 IMP:MGI P sex differentiation
GO:0006105 IMP:BHF-UCL P succinate metabolic process
GO:0019530 IMP:BHF-UCL P taurine metabolic process
GO:0006366 IEA:Ensembl P transcription from RNA polymerase II promoter
GO:0006573 IMP:BHF-UCL P valine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu05166 HTLV-I infection
mmu05161 Hepatitis B
mmu04917 Prolactin signaling pathway
mmu05203 Viral carcinogenesis

Domain Information

InterPro Annotations

Accession Description
IPR011992 EF-hand domain pair
IPR000980 SH2 domain
IPR013801 STAT transcription factor, DNA-binding
IPR012345 STAT transcription factor, DNA-binding, subdomain
IPR013800 STAT transcription factor, all-alpha
IPR015988 STAT transcription factor, coiled coil
IPR013799 STAT transcription factor, protein interaction
IPR001217 Transcription factor STAT
IPR008967 p53-like transcription factor, DNA-binding

UniProt Annotations

Entry Information

Gene Name
signal transducer and activator of transcription 5B
Protein Entry
STA5B_MOUSE
UniProt ID
P42232
Species
Mouse

Comments

Comment Type Description
Developmental Stage Detected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation.
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. {ECO:0000269|PubMed:11773439}.
Interaction Q96EY1:DNAJA3 (xeno); NbExp=3; IntAct=EBI-617454, EBI-356767; Q96EY1-1:DNAJA3 (xeno); NbExp=2; IntAct=EBI-617454, EBI-4322330; Q96EY1-2:DNAJA3 (xeno); NbExp=2; IntAct=EBI-617454, EBI-3952284; P19941:GHR (xeno); NbExp=6; IntAct=EBI-617454, EBI-7526279;
Polymorphism The polymorphism at position 327 in strain NOD reduces DNA-binding affinity.
Ptm Tyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:11773439, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21262971}.
Similarity Belongs to the transcription factor STAT family. {ECO:0000305}.
Similarity Contains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Subunit Forms a homodimer or a heterodimer with a related family member. Interacts with SOCS7 (By similarity). Binds NR3C1 and NCOA1. Interacts (via SH2 domain) with INSR. {ECO:0000250, ECO:0000269|PubMed:9428692, ECO:0000269|PubMed:9528750}.
Tissue Specificity In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.

Identical and Related Proteins

Unique RefSeq proteins for LMP000560 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
165932366 RefSeq NP_035619 786 signal transducer and activator of transcription 5B

Identical Sequences to LMP000560 proteins

Reference Database Accession Length Protein Name
GI:165932366 DBBJ BAE32752.1 786 unnamed protein product [Mus musculus]
GI:165932366 DBBJ BAE29305.1 786 unnamed protein product [Mus musculus]
GI:165932366 EMBL CAG32956.1 786 unnamed protein product [Mus musculus]
GI:165932366 GenBank AAF62911.2 786 STAT5B [Mus musculus]
GI:165932366 GenBank AAH24319.1 786 Stat5b protein [Mus musculus]
GI:165932366 RefSeq NP_001107035.1 786 signal transducer and activator of transcription 5B [Mus musculus]

Related Sequences to LMP000560 proteins

Reference Database Accession Length Protein Name
GI:165932366 DBBJ BAE32317.1 786 unnamed protein product [Mus musculus]
GI:165932366 GenBank AAE46141.1 786 Sequence 11 from patent US 6087478
GI:165932366 GenBank AAE86055.1 786 Sequence 11 from patent US 6312887
GI:165932366 GenBank AAK74074.1 786 signal transducer and activator of transcription 5B [Mus musculus]
GI:165932366 GenBank AIU94959.1 1480 STAT5-HKRR [Load driver vector pLDBUFL]
GI:165932366 GenBank AIU94971.1 1480 STAT5-HKRR [Load driver vector pLDBUF]