Gene/Proteome Database (LMPD)

LMPD ID
LMP000558
Gene ID
20850
Species
Mus musculus (Mouse)
Gene Name
signal transducer and activator of transcription 5A
Gene Symbol
Stat5a
Synonyms
AA959963; STAT5
Chromosome
11
Map Location
11 D|11 63.77 cM

Proteins

signal transducer and activator of transcription 5A isoform 1
Refseq ID NP_035618
Protein GI 6755672
UniProt ID Q9JIA0
mRNA ID NM_011488
Length 793
RefSeq Status VALIDATED
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASTDAGASATYMDQAPSPVVCPQPHYNMYPPNPDPVLDQDGEFDLDESMDVARHVEELLRRPMDSLDARLSPPAGLFTSARSSLS
signal transducer and activator of transcription 5A isoform 2
Refseq ID NP_001157534
Protein GI 255759968
UniProt ID Q3UZ79
mRNA ID NM_001164062
Length 797
RefSeq Status VALIDATED
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLGSSMHPQMPEPAPPTWTRLLPQSCALNLTTTCTHPTLTLSLTKMASLTWMRAWMLPGTWKNFYAGPWTVSTPASPHLLVSSPPLEAPCPERWTPCFSWKTTFSVRSPRQL

Gene Information

Entrez Gene ID
20850
Gene Name
signal transducer and activator of transcription 5A
Gene Symbol
Stat5a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005634 IEA:UniProtKB-SubCell C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0000979 IDA:MGI F RNA polymerase II core promoter sequence-specific DNA binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0004871 IGI:MGI F signal transducer activity
GO:0007259 IDA:MGI P JAK-STAT cascade
GO:0048541 IGI:MGI P Peyer's patch development
GO:0033077 IGI:MGI P T cell differentiation in thymus
GO:0043029 IGI:MGI P T cell homeostasis
GO:0097011 IDA:MGI P cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0019221 IDA:MGI P cytokine-mediated signaling pathway
GO:0046543 IMP:MGI P development of secondary female sexual characteristics
GO:0046544 IMP:MGI P development of secondary male sexual characteristics
GO:0060742 IMP:MGI P epithelial cell differentiation involved in prostate gland development
GO:0007565 IGI:MGI P female pregnancy
GO:0007595 IMP:MGI P lactation
GO:0019915 IGI:MGI P lipid storage
GO:0001553 IGI:MGI P luteinization
GO:0030879 IMP:MGI P mammary gland development
GO:0061180 IMP:MGI P mammary gland epithelium development
GO:0001779 IGI:MGI P natural killer cell differentiation
GO:0043066 IGI:MGI P negative regulation of apoptotic process
GO:0045647 IGI:MGI P negative regulation of erythrocyte differentiation
GO:0033026 IMP:MGI P negative regulation of mast cell apoptotic process
GO:0018108 IDA:MGI P peptidyl-tyrosine phosphorylation
GO:0045579 IGI:MGI P positive regulation of B cell differentiation
GO:0042104 IDA:MGI P positive regulation of activated T cell proliferation
GO:0008284 IDA:MGI P positive regulation of cell proliferation
GO:0045588 IGI:MGI P positive regulation of gamma-delta T cell differentiation
GO:0050729 IGI:MGI P positive regulation of inflammatory response
GO:0045086 IGI:MGI P positive regulation of interleukin-2 biosynthetic process
GO:0045621 IGI:MGI P positive regulation of lymphocyte differentiation
GO:0060376 IMP:MGI P positive regulation of mast cell differentiation
GO:0070668 IMP:MGI P positive regulation of mast cell proliferation
GO:0045931 IGI:MGI P positive regulation of mitotic cell cycle
GO:0040018 IGI:MGI P positive regulation of multicellular organism growth
GO:0032825 IMP:MGI P positive regulation of natural killer cell differentiation
GO:0045954 IMP:MGI P positive regulation of natural killer cell mediated cytotoxicity
GO:0045944 IDA:MGI P positive regulation of transcription from RNA polymerase II promoter
GO:0060740 IMP:MGI P prostate gland epithelium morphogenesis
GO:0030155 IMP:MGI P regulation of cell adhesion
GO:0030856 IMP:MGI P regulation of epithelial cell differentiation
GO:0019218 IGI:MGI P regulation of steroid metabolic process
GO:0006357 IDA:MGI P regulation of transcription from RNA polymerase II promoter
GO:0043434 IDA:MGI P response to peptide hormone
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR011992 EF-hand domain pair
IPR000980 SH2 domain
IPR013801 STAT transcription factor, DNA-binding
IPR012345 STAT transcription factor, DNA-binding, subdomain
IPR013800 STAT transcription factor, all-alpha
IPR015988 STAT transcription factor, coiled coil
IPR013799 STAT transcription factor, protein interaction
IPR001217 Transcription factor STAT
IPR008967 p53-like transcription factor, DNA-binding

UniProt Annotations

Entry Information

Gene Name
signal transducer and activator of transcription 5A
Protein Entry
STA5A_MOUSE
UniProt ID
Q9JIA0
Species
Mouse

Comments

Comment Type Description
Similarity Belongs to the transcription factor STAT family.
Similarity Contains 1 SH2 domain.
Subcellular Location Cytoplasm .
Subcellular Location Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP000558 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6755672 RefSeq NP_035618 793 signal transducer and activator of transcription 5A isoform 1
255759968 RefSeq NP_001157534 797 signal transducer and activator of transcription 5A isoform 2

Identical Sequences to LMP000558 proteins

Reference Database Accession Length Protein Name
GI:6755672 DBBJ BAE32355.1 793 unnamed protein product [Mus musculus]
GI:6755672 EMBL CAG32955.1 793 unnamed protein product [Mus musculus]
GI:6755672 GenBank AAQ75420.1 793 signal transducer and activator of transcription 5A [Mus musculus]
GI:6755672 GenBank AAQ75421.1 793 signal transducer and activator of transcription 5A [Mus musculus]
GI:255759968 GenBank ABY79096.1 797 STAT5a variant delta E18 [Mus musculus]
GI:255759968 RefSeq XP_006532782.1 797 PREDICTED: signal transducer and activator of transcription 5A isoform X1 [Mus musculus]
GI:255759968 RefSeq XP_006532783.1 797 PREDICTED: signal transducer and activator of transcription 5A isoform X2 [Mus musculus]
GI:6755672 RefSeq XP_006532784.1 793 PREDICTED: signal transducer and activator of transcription 5A isoform X3 [Mus musculus]
GI:6755672 RefSeq XP_006532785.1 793 PREDICTED: signal transducer and activator of transcription 5A isoform X4 [Mus musculus]

Related Sequences to LMP000558 proteins

Reference Database Accession Length Protein Name
GI:6755672 EMBL CAG32957.1 793 unnamed protein product [synthetic construct]
GI:6755672 EMBL CAG32958.1 793 unnamed protein product [synthetic construct]
GI:255759968 GenBank AAE46140.1 793 Sequence 10 from patent US 6087478
GI:255759968 GenBank AAH08998.1 793 Signal transducer and activator of transcription 5A [Mus musculus]
GI:255759968 GenBank AAE86054.1 793 Sequence 10 from patent US 6312887
GI:255759968 GenBank AAF78237.2 793 transcription factor Stat5a [Mus musculus]
GI:6755672 GenBank EDM06067.1 793 rCG35111 [Rattus norvegicus]
GI:6755672 GenBank EGW08040.1 793 Signal transducer and activator of transcription 5A [Cricetulus griseus]
GI:6755672 RefSeq XP_003504693.1 793 PREDICTED: signal transducer and activator of transcription 5A isoform X1 [Cricetulus griseus]
GI:255759968 RefSeq XP_005257681.1 761 PREDICTED: signal transducer and activator of transcription 5A isoform X4 [Homo sapiens]
GI:6755672 RefSeq XP_006992967.1 793 PREDICTED: signal transducer and activator of transcription 5A [Peromyscus maniculatus bairdii]
GI:255759968 RefSeq XP_009430438.1 742 PREDICTED: signal transducer and activator of transcription 5A isoform X3 [Pan troglodytes]