Gene/Proteome Database (LMPD)

LMPD ID
LMP000554
Gene ID
18795
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, beta 1
Gene Symbol
Plcb1
Synonyms
3110043I21Rik; AI132408; Plcb; mKIAA0581
Chromosome
2
Map Location
2 F3|2 65.66 cM

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1
Refseq ID NP_001139302
Protein GI 224967070
UniProt ID Q3UPW0
mRNA ID NM_001145830
Length 1216
RefSeq Status VALIDATED
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKPKLQTELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASDAAKVNLKSPSSEEIERENPGREFDTPL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2
Refseq ID NP_062651
Protein GI 224967068
UniProt ID Q3UPW0
mRNA ID NM_019677
Length 1173
RefSeq Status VALIDATED
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKPKGEGPSSVLSEGCHEDPSVPPNFTPPNPQALKW

Gene Information

Entrez Gene ID
18795
Gene Name
phospholipase C, beta 1
Gene Symbol
Plcb1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:InterPro C cytoplasm
GO:0005634 IEA:InterPro C nucleus
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0007420 IEA:InterPro P brain development
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0051726 IEA:InterPro P regulation of cell cycle

Domain Information

InterPro Annotations

Accession Description
IPR028400 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 1
Protein Entry
PLCB1_MOUSE
UniProt ID
Q3UPW0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Similarity Contains 1 PI-PLC X-box domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000554 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
224967070 RefSeq NP_001139302 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1
224967068 RefSeq NP_062651 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2

Identical Sequences to LMP000554 proteins

Reference Database Accession Length Protein Name
GI:224967070 GenBank AAH58710.1 1216 Plcb1 protein [Mus musculus]
GI:224967068 GenBank ABK42329.1 1173 phospholipase C-beta1 [synthetic construct]
GI:224967068 GenBank EDL28376.1 1173 phospholipase C, beta 1, isoform CRA_a [Mus musculus]
GI:224967070 SwissProt Q9Z1B3.2 1216 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; AltName: Full=PLC-154; AltName: Full=Phosphoinositide phospholipase C-beta-1; AltName: Full=Phospholipase C-beta-1; Short=PLC-beta-1 [Mus musculus]

Related Sequences to LMP000554 proteins

Reference Database Accession Length Protein Name
GI:224967070 EMBL CBU87837.1 1216 unnamed protein product [Mus musculus]
GI:224967070 EMBL CBU96784.1 1216 unnamed protein product [Mus musculus]
GI:224967070 GenBank AAA41885.1 1216 phospholipase C-1 [Rattus sp.]
GI:224967068 GenBank AAD00572.1 1173 phospholipase C-beta-1b [Mus musculus]
GI:224967068 GenBank AAD00573.1 1173 phospholipase C-beta-1b' [Mus musculus]
GI:224967068 GenBank AFX07218.1 1173 Sequence 20 from patent US 8283445
GI:224967068 GenBank JAB31315.1 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b [Callithrix jacchus]
GI:224967068 GenBank JAB45223.1 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b [Callithrix jacchus]
GI:224967070 RefSeq NP_001071109.1 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [Rattus norvegicus]
GI:224967068 RefSeq XP_006984028.1 1173 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [Peromyscus maniculatus bairdii]
GI:224967070 RefSeq XP_008760469.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [Rattus norvegicus]
GI:224967070 SwissProt P10687.1 1216 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; AltName: Full=PLC-154; AltName: Full=Phosphoinositide phospholipase C-beta-1; AltName: Full=Phospholipase C-I; Short=PLC-I; AltName: Full=Phospholipase C-beta-1; Short=PLC-beta-1 [Rattus norvegicus]