Gene/Proteome Database (LMPD)

LMPD ID
LMP000439
Gene ID
11684
Species
Mus musculus (Mouse)
Gene Name
arachidonate 12-lipoxygenase
Gene Symbol
Alox12
Synonyms
9930022G08Rik; Alox12p; P-12LO
Chromosome
11
Map Location
11 B3|11 42.99 cM

Proteins

arachidonate 12-lipoxygenase, 12S-type
Refseq ID NP_031466
Protein GI 31542127
UniProt ID P39655
mRNA ID NM_007440
Length 663
RefSeq Status VALIDATED
MGRYRVRVVTGAWLFSGSLNLVRLWLVGEHREAKLELQLRPARGKEEEFDFDVPEDLGPLQFVKLHKQHTVVDDAWFCNLITVQGPGTSAEAVFPCYRWVQGEGILSLPEGTARLAGDNALDVFQKYREKELKERQQTYCWATWKEGLPQTIAADCKDDLPPNMRFHEEKRLDFEWTLKAGVLEMGLKRVYTLLRSWNHLEDFDQIFWGQKSALAEKVHQCWQEDELFGYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELKNGSLFEADFILLDGIPANVIRGEPQYLAAPLVMLRMDPGGKLLPMAIQIQPPNPSSPAPTLFLPSDPPLAWLLAKIWVRNSDFQLQELQFHLLNTHLVAEVIAVATMRCLPGLHPIFKLLVPHIRYTMEINTRSRTQLISDGGIFDQVVSTGGGGHVQLLTRAVAQLTYHSLCPPDDLANRGLLRIPSALYARDALQLWEVTARYVKGMVHLFYQSDDIVRGDPELQAWCREITEVGLCHAQDRGFPVSFQSRAQLCHFLTMCVFTCTAQHAAINQGQLDWYGWVPNAPCTMRMPPPTSKDDVTMETVMGSLPDVQKACLQMTITWHLGRLQPDMVPLGHHTEKYFSDPRTKAVLSQFQADLDNLEKEITARNEQLDLPYEYLKPSRIENSITI

Gene Information

Entrez Gene ID
11684
Gene Name
arachidonate 12-lipoxygenase
Gene Symbol
Alox12
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0042383 IEA:Ensembl C sarcolemma
GO:0004052 IEA:Ensembl F arachidonate 12-lipoxygenase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0016165 IEA:Ensembl F linoleate 13S-lipoxygenase activity
GO:0007568 IEA:Ensembl P aging
GO:0019369 IEA:Ensembl P arachidonic acid metabolic process
GO:0006928 IEA:Ensembl P cellular component movement
GO:0071396 IEA:Ensembl P cellular response to lipid
GO:0019395 IEA:Ensembl P fatty acid oxidation
GO:0051122 IEA:Ensembl P hepoxilin biosynthetic process
GO:1901751 IEA:Ensembl P leukotriene A4 metabolic process
GO:0043651 IEA:Ensembl P linoleic acid metabolic process
GO:2001303 IEA:Ensembl P lipoxin A4 biosynthetic process
GO:2001306 IEA:Ensembl P lipoxin B4 biosynthetic process
GO:0019372 IEA:Ensembl P lipoxygenase pathway
GO:0010656 IEA:Ensembl P negative regulation of muscle cell apoptotic process
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0045785 IEA:Ensembl P positive regulation of cell adhesion
GO:0030307 IEA:Ensembl P positive regulation of cell growth
GO:0043280 IEA:Ensembl P positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045603 IEA:Ensembl P positive regulation of endothelial cell differentiation
GO:0010595 IEA:Ensembl P positive regulation of endothelial cell migration
GO:0010628 IEA:Ensembl P positive regulation of gene expression
GO:0051901 IEA:Ensembl P positive regulation of mitochondrial depolarization
GO:0048661 IEA:Ensembl P positive regulation of smooth muscle cell proliferation
GO:0045909 IEA:Ensembl P positive regulation of vasodilation

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR020833 Lipoxygenase, iron binding site
IPR001885 Lipoxygenase, mammalian
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
arachidonate 12-lipoxygenase
Protein Entry
LOX12_MOUSE
UniProt ID
P39655
Species
Mouse

Comments

Comment Type Description
Cofactor Note=Iron. ;
Similarity Belongs to the lipoxygenase family.
Similarity Contains PLAT domain.
Similarity Contains lipoxygenase domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000439 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31542127 RefSeq NP_031466 663 arachidonate 12-lipoxygenase, 12S-type

Identical Sequences to LMP000439 proteins

Reference Database Accession Length Protein Name
GI:31542127 DBBJ BAC29629.1 663 unnamed protein product [Mus musculus]
GI:31542127 DBBJ BAC39981.1 663 unnamed protein product [Mus musculus]
GI:31542127 GenBank AAI52330.1 663 Arachidonate 12-lipoxygenase [Mus musculus]
GI:31542127 GenBank AAI52404.1 663 Arachidonate 12-lipoxygenase [Mus musculus]
GI:31542127 GenBank AAI65994.1 663 Arachidonate 12-lipoxygenase [synthetic construct]
GI:31542127 SwissProt P39655.4 663 RecName: Full=Arachidonate 12-lipoxygenase, 12S-type; Short=12S-LOX; Short=12S-lipoxygenase; AltName: Full=Lipoxin synthase 12-LO; AltName: Full=Platelet-type lipoxygenase 12; Short=P-12LO [Mus musculus]

Related Sequences to LMP000439 proteins

Reference Database Accession Length Protein Name
GI:31542127 DBBJ BAE42887.1 663 unnamed protein product [Mus musculus]
GI:31542127 DBBJ BAE43031.1 663 unnamed protein product [Mus musculus]
GI:31542127 GenBank AAA20659.1 663 platelet-type 12-lipoxygenase [Mus musculus]
GI:31542127 GenBank AAB36013.1 663 12-lipoxygenase [Mus sp.]
GI:31542127 GenBank EDL12551.1 663 arachidonate 12-lipoxygenase, isoform CRA_b [Mus musculus]
GI:31542127 SwissProt F1LQ70.1 663 RecName: Full=Arachidonate 12-lipoxygenase, 12S-type; Short=12S-LOX; Short=12S-lipoxygenase; AltName: Full=Lipoxin synthase 12-LO; AltName: Full=Platelet-type lipoxygenase 12 [Rattus norvegicus]