Gene/Proteome Database (LMPD)

LMPD ID
LMP000434
Gene ID
13123
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 7, subfamily b, polypeptide 1
Gene Symbol
Cyp7b1
Synonyms
AW261589; D3Ertd552e; hct-1
Chromosome
3
Map Location
3 A1|3 4.98 cM

Proteins

25-hydroxycholesterol 7-alpha-hydroxylase
Refseq ID NP_031851
Protein GI 160707927
UniProt ID Q3USU4
mRNA ID NM_007825
Length 507
RefSeq Status VALIDATED
MQGATTLDAASPGPLALLGLLFAATLLLSALFLLTRRTRRPREPPLIKGWLPYLGMALKFFKDPLTFLKTLQRQHGDTFTVFLVGKYITFVLNPFQYQYVTKNPKQLSFQKFSSRLSAKAFSVKKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQEVKELFESQLLKITDWNTERIFAFCGSLVFEITFATLYGKILAGNKKQIISELRDDFFKFDDMFPYLVSDIPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQERQDLLKRYYRHDDPEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESTILEVLRLCSYSSIIREVQEDMNLSLESKSFSLRKGDFVALFPPLIHNDPEIFDAPKEFRFDRFIEDGKKKSTFFKGGKKLKTYVMPFGLGTSKCPGRYFAVNEMKLLLIMLLTYFDLEIIDRKPIGLNHSRMFLGIQHPDSAVSFRYKAKSWRS

Gene Information

Entrez Gene ID
13123
Gene Name
cytochrome P450, family 7, subfamily b, polypeptide 1
Gene Symbol
Cyp7b1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:UniProtKB-SubCell C endoplasmic reticulum membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:InterPro F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0033147 IMP:MGI P negative regulation of intracellular estrogen receptor signaling pathway
GO:0050679 IMP:MGI P positive regulation of epithelial cell proliferation
GO:0060740 IMP:MGI P prostate gland epithelium morphogenesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 7, subfamily b, polypeptide 1
Protein Entry
CP7B1_MOUSE
UniProt ID
Q3USU4
Species
Mouse

Comments

Comment Type Description
Cofactor Note=Heme group. {ECO:0000256|PIRNR:PIRNR000047, ECO:0000256|PIRSR:PIRSR000047-1};
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane .

Identical and Related Proteins

Unique RefSeq proteins for LMP000434 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160707927 RefSeq NP_031851 507 25-hydroxycholesterol 7-alpha-hydroxylase

Identical Sequences to LMP000434 proteins

Reference Database Accession Length Protein Name
GI:160707927 DBBJ BAB28613.1 507 unnamed protein product [Mus musculus]
GI:160707927 RefSeq XP_006535446.1 507 PREDICTED: 25-hydroxycholesterol 7-alpha-hydroxylase isoform X1 [Mus musculus]
GI:160707927 SwissProt Q60991.2 507 RecName: Full=25-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 7B1; AltName: Full=Hippocampal transcript 1 protein; Short=HCT-1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Mus musculus]

Related Sequences to LMP000434 proteins

Reference Database Accession Length Protein Name
GI:160707927 DBBJ BAE24236.1 507 unnamed protein product [Mus musculus]
GI:160707927 EMBL CAB39337.1 507 unnamed protein product [unidentified]
GI:160707927 GenBank AAA92615.1 507 cytochrome P450 Cyp7b1 [Mus musculus]
GI:160707927 GenBank AAE33973.1 507 Sequence 4 from patent US 5976850
GI:160707927 GenBank AAH38810.1 507 Cytochrome P450, family 7, subfamily b, polypeptide 1 [Mus musculus]
GI:160707927 GenBank EDL34867.1 507 cytochrome P450, family 7, subfamily b, polypeptide 1 [Mus musculus]