Gene/Proteome Database (LMPD)

LMPD ID
LMP000399
Gene ID
10424
Species
Homo sapiens (Human)
Gene Name
progesterone receptor membrane component 2
Gene Symbol
PGRMC2
Synonyms
DG6; PMBP
Alternate Names
membrane-associated progesterone receptor component 2; steroid receptor protein DG6; progesterone membrane binding protein
Chromosome
4
Map Location
4q26

Proteins

membrane-associated progesterone receptor component 2
Refseq ID NP_006311
Protein GI 291621647
UniProt ID O15173
mRNA ID NM_006320
Length 247
RefSeq Status VALIDATED
MGGAGRGVGEGRGRGGGGRRWRAVMAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD

Gene Information

Entrez Gene ID
10424
Gene Name
progesterone receptor membrane component 2
Gene Symbol
PGRMC2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 TAS:ProtInc C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005496 TAS:ProtInc F steroid binding
GO:0003707 TAS:ProtInc F steroid hormone receptor activity
GO:0043401 TAS:GOC P steroid hormone mediated signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain

UniProt Annotations

Entry Information

Gene Name
progesterone receptor membrane component 2
Protein Entry
PGRC2_HUMAN
UniProt ID
O15173
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15173-1; Sequence=Displayed; Name=2; IsoId=O15173-2; Sequence=VSP_053500; Note=No experimental confirmation available.;
Domain The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
Function Receptor for steroids.
Similarity Belongs to the cytochrome b5 family. MAPR subfamily.
Similarity Contains 1 cytochrome b5 heme-binding domain.
Subcellular Location Membrane ; Single-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP000399 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
291621647 RefSeq NP_006311 247 membrane-associated progesterone receptor component 2

Identical Sequences to LMP000399 proteins

Reference Database Accession Length Protein Name
GI:291621647 EMBL CAE11578.1 247 unnamed protein product [Homo sapiens]

Related Sequences to LMP000399 proteins

Reference Database Accession Length Protein Name
GI:291621647 GenBank JAA21133.1 247 progesterone receptor membrane component 2 [Pan troglodytes]
GI:291621647 RefSeq XP_001082791.1 247 PREDICTED: membrane-associated progesterone receptor component 2 [Macaca mulatta]
GI:291621647 RefSeq XP_517434.2 247 PREDICTED: membrane-associated progesterone receptor component 2 [Pan troglodytes]
GI:291621647 RefSeq XP_005555963.1 247 PREDICTED: membrane-associated progesterone receptor component 2 isoform X1 [Macaca fascicularis]
GI:291621647 RefSeq XP_006212294.1 247 PREDICTED: membrane-associated progesterone receptor component 2 [Vicugna pacos]
GI:291621647 RefSeq XP_007997976.1 247 PREDICTED: membrane-associated progesterone receptor component 2 [Chlorocebus sabaeus]