Gene/Proteome Database (LMPD)

LMPD ID
LMP000396
Gene ID
19088
Species
Mus musculus (Mouse)
Gene Name
protein kinase, cAMP dependent regulatory, type II beta
Gene Symbol
Prkar2b
Synonyms
AI451071; AW061005; PKARIIbeta; Pkarb2; RII(beta)
Alternate Names
cAMP-dependent protein kinase type II-beta regulatory subunit
Chromosome
12
Map Location
12|12 B1

Proteins

cAMP-dependent protein kinase type II-beta regulatory subunit
Refseq ID NP_035288
Protein GI 45598396
UniProt ID P31324
mRNA ID NM_011158
Length 416
RefSeq Status VALIDATED
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA

Gene Information

Entrez Gene ID
19088
Gene Name
protein kinase, cAMP dependent regulatory, type II beta
Gene Symbol
Prkar2b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005952 IEA:InterPro C cAMP-dependent protein kinase complex
GO:0005813 IEA:Ensembl C centrosome
GO:0097546 IDA:MGI C ciliary base
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0043198 IDA:ParkinsonsUK-UCL C dendritic shaft
GO:0043197 IDA:ParkinsonsUK-UCL C dendritic spine
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0030552 IEA:UniProtKB-KW F cAMP binding
GO:0004862 IEA:Ensembl F cAMP-dependent protein kinase inhibitor activity
GO:0008603 IDA:MGI F cAMP-dependent protein kinase regulator activity
GO:0019901 IPI:ParkinsonsUK-UCL F protein kinase binding
GO:0006631 IMP:MGI P fatty acid metabolic process
GO:0007612 IMP:MGI P learning
GO:2000480 IEA:Ensembl P negative regulation of cAMP-dependent protein kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
mmu04210 Apoptosis
mmu04910 Insulin signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000595 Cyclic nucleotide-binding domain
IPR018488 Cyclic nucleotide-binding, conserved site
IPR018490 Cyclic nucleotide-binding-like
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR014710 RmlC-like jelly roll fold
IPR012198 cAMP-dependent protein kinase regulatory subunit
IPR002373 cAMP/cGMP-dependent protein kinase

UniProt Annotations

Entry Information

Gene Name
protein kinase, cAMP dependent regulatory, type II beta
Protein Entry
KAP3_MOUSE
UniProt ID
P31324
Species
Mouse

Comments

Comment Type Description
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Interaction Q5S006:Lrrk2; NbExp=3; IntAct=EBI-455340, EBI-2693710; P05132:Prkaca; NbExp=3; IntAct=EBI-455340, EBI-400564;
Ptm Phosphorylated by the activated catalytic chain. {ECO:0000269|PubMed:16452087, ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:19131326}.
Similarity Belongs to the cAMP-dependent kinase regulatory chain family. {ECO:0000305}.
Similarity Contains 2 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. {ECO:0000250}.
Subunit The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2 (By similarity). {ECO:0000250}.
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Identical and Related Proteins

Unique RefSeq proteins for LMP000396 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45598396 RefSeq NP_035288 416 cAMP-dependent protein kinase type II-beta regulatory subunit

Identical Sequences to LMP000396 proteins

Reference Database Accession Length Protein Name
GI:45598396 DBBJ BAC30779.1 416 unnamed protein product [Mus musculus]
GI:45598396 DBBJ BAE23838.1 416 unnamed protein product [Mus musculus]
GI:45598396 RefSeq XP_006515077.1 416 PREDICTED: cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1 [Mus musculus]
GI:45598396 SwissProt P31324.3 416 RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit [Mus musculus]

Related Sequences to LMP000396 proteins

Reference Database Accession Length Protein Name
GI:45598396 GenBank AAH48710.1 416 Prkar2b protein [Mus musculus]
GI:45598396 GenBank EDL36899.1 448 protein kinase, cAMP dependent regulatory, type II beta, isoform CRA_b, partial [Mus musculus]
GI:45598396 GenBank EDL36900.1 448 protein kinase, cAMP dependent regulatory, type II beta, isoform CRA_b, partial [Mus musculus]
GI:45598396 PDB 3TNP 416 Chain B, Structure And Allostery Of The Pka Riib Tetrameric Holoenzyme
GI:45598396 PDB 3TNP 416 Chain E, Structure And Allostery Of The Pka Riib Tetrameric Holoenzyme
GI:45598396 PDB 3TNQ 416 Chain A, Structure And Allostery Of The Pka Riib Tetrameric Holoenzyme