Gene/Proteome Database (LMPD)

LMPD ID
LMP000375
Gene ID
93747
Species
Mus musculus (Mouse)
Gene Name
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Gene Symbol
Echs1
Synonyms
C80529
Alternate Names
enoyl-CoA hydratase, mitochondrial; SCEH; enoyl-CoA hydratase 1; short chain enoyl-CoA hydratase; short-chain enoyl-CoA hydratase
Chromosome
7
Map Location
7 F4|7
EC Number
4.2.1.17

Proteins

enoyl-CoA hydratase, mitochondrial precursor
Refseq ID NP_444349
Protein GI 29789289
UniProt ID Q8BH95
mRNA ID NM_053119
Length 290
RefSeq Status PROVISIONAL
MAALRALLPRACSSLLSSVRCPELRRFASGANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDKAFAAGADIKEMQNRTFQDCYSSKFLSHWDHITRVKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVEKLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGNKLEKRLFYSTFATDDRREGMTAFVEKRKANFKDH
transit_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q8BH95.1) calculated_mol_wt: 3018 peptide sequence: MAALRALLPRACSSLLSSVRCPELRRF mat_peptide: 28..290 product: Enoyl-CoA hydratase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8BH95.1) calculated_mol_wt: 28475 peptide sequence: ASGANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDKAFAAGADIKEMQNRTFQDCYSSKFLSHWDHITRVKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVEKLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGNKLEKRLFYSTFATDDRREGMTAFVEKRKANFKDH

Gene Information

Entrez Gene ID
93747
Gene Name
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Gene Symbol
Echs1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0004300 IEA:UniProtKB-EC F enoyl-CoA hydratase activity
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Protein Entry
ECHM_MOUSE
UniProt ID
Q8BH95
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Function Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. {ECO:0000250}.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Ptm Acetylation of Lys-101 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753}.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Homohexamer; dimer of trimers. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000375 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
29789289 RefSeq NP_444349 290 enoyl-CoA hydratase, mitochondrial precursor

Identical Sequences to LMP000375 proteins

Reference Database Accession Length Protein Name
GI:29789289 DBBJ BAC30583.1 290 unnamed protein product [Mus musculus]
GI:29789289 DBBJ BAC32157.1 290 unnamed protein product [Mus musculus]
GI:29789289 DBBJ BAC40099.1 290 unnamed protein product [Mus musculus]
GI:29789289 DBBJ BAE39493.1 290 unnamed protein product [Mus musculus]
GI:29789289 GenBank EDL17912.1 290 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, isoform CRA_d [Mus musculus]
GI:29789289 SwissProt Q8BH95.1 290 RecName: Full=Enoyl-CoA hydratase, mitochondrial; AltName: Full=Enoyl-CoA hydratase 1; AltName: Full=Short-chain enoyl-CoA hydratase; Short=SCEH; Flags: Precursor [Mus musculus]

Related Sequences to LMP000375 proteins

Reference Database Accession Length Protein Name
GI:29789289 GenBank AAH02178.1 288 Echs1 protein, partial [Mus musculus]
GI:29789289 GenBank AAH64655.1 290 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [Rattus norvegicus]
GI:29789289 GenBank AAH72658.1 290 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [Mus musculus]
GI:29789289 GenBank ABP13466.1 290 Sequence 48 from patent US 7186541
GI:29789289 GenBank EDM11897.1 290 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, isoform CRA_a [Rattus norvegicus]
GI:29789289 GenBank ADC21052.1 290 Sequence 48 from patent US 7638316