Gene/Proteome Database (LMPD)
LMPD ID
LMP000351
Gene ID
Species
Homo sapiens (Human)
Gene Name
zinc finger, DHHC-type containing 17
Gene Symbol
Synonyms
HIP14; HIP3; HYPH
Alternate Names
palmitoyltransferase ZDHHC17; HIP-3; HIP-14; DHHC-17; huntingtin yeast partner H; Huntingtin interacting protein H; huntingtin interacting protein 3; huntingtin-interacting protein 3; huntingtin-interacting protein H; huntingtin interacting protein 14; huntingtin-interacting protein 14; putative MAPK-activating protein PM11; zinc finger, DHHC domain containing 17; putative NF-kappa-B-activating protein 205; zinc finger DHHC domain-containing protein 17
Chromosome
12
Map Location
12q21.2
EC Number
2.3.1.225
Proteins
| palmitoyltransferase ZDHHC17 | |
|---|---|
| Refseq ID | NP_056151 |
| Protein GI | 103471993 |
| UniProt ID | Q8IUH5 |
| mRNA ID | NM_015336 |
| Length | 632 |
| RefSeq Status | VALIDATED |
| MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV | |
Gene Information
Entrez Gene ID
Gene Name
zinc finger, DHHC-type containing 17
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:UniProt | C | Golgi apparatus |
| GO:0000139 | IDA:UniProtKB | C | Golgi membrane |
| GO:0030660 | IDA:UniProtKB | C | Golgi-associated vesicle membrane |
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0043231 | IDA:HPA | C | intracellular membrane-bounded organelle |
| GO:0042802 | IPI:IntAct | F | identical protein binding |
| GO:0015095 | IDA:UniProtKB | F | magnesium ion transmembrane transporter activity |
| GO:0016409 | IDA:UniProt | F | palmitoyltransferase activity |
| GO:0019706 | IDA:UniProtKB | F | protein-cysteine S-palmitoyltransferase activity |
| GO:0004871 | IMP:UniProtKB | F | signal transducer activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0042953 | IDA:UniProtKB | P | lipoprotein transport |
| GO:0015693 | IDA:GOC | P | magnesium ion transport |
| GO:0043123 | IMP:UniProtKB | P | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| GO:0018345 | IDA:UniProt | P | protein palmitoylation |
| GO:0007165 | IMP:GOC | P | signal transduction |
Domain Information
UniProt Annotations
Entry Information
Gene Name
zinc finger, DHHC-type containing 17
Protein Entry
ZDH17_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IUH5-1; Sequence=Displayed; Name=2; IsoId=Q8IUH5-2; Sequence=VSP_010021, VSP_010022, VSP_010024, VSP_010025; Name=3; IsoId=Q8IUH5-3; Sequence=VSP_010023; Note=No experimental confirmation available.; |
| Biophysicochemical Properties | Kinetic parameters: KM=0.87 mM for for magnesium ions; |
| Catalytic Activity | Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA. |
| Domain | The DHHC domain is required for palmitoyltransferase activity. |
| Function | Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. {ECO |
| Interaction | Self; NbExp=6; IntAct=EBI-524753, EBI-524753; Q7Z783:-; NbExp=3; IntAct=EBI-524753, EBI-9088990; Q7Z5R6:APBB1IP; NbExp=2; IntAct=EBI-524753, EBI-2818084; Q9NP61:ARFGAP3; NbExp=2; IntAct=EBI-524753, EBI-2875816; P15336:ATF2; NbExp=3; IntAct=EBI-524753, EBI-1170906; Q9UQB8-3:BAIAP2; NbExp=3; IntAct=EBI-524753, EBI-9091996; Q9UQB8-6:BAIAP2; NbExp=2; IntAct=EBI-524753, EBI-9092016; P17655:CAPN2; NbExp=2; IntAct=EBI-524753, EBI-1028956; Q96GN5-2:CDCA7L; NbExp=2; IntAct=EBI-524753, EBI-9091443; P48730-2:CSNK1D; NbExp=3; IntAct=EBI-524753, EBI-9087876; P68104:EEF1A1; NbExp=2; IntAct=EBI-524753, EBI-352162; P60228:EIF3E; NbExp=2; IntAct=EBI-524753, EBI-347740; Q9UI08-2:EVL; NbExp=2; IntAct=EBI-524753, EBI-6448852; Q9UHY8:FEZ2; NbExp=4; IntAct=EBI-524753, EBI-396453; Q08379:GOLGA2; NbExp=3; IntAct=EBI-524753, EBI-618309; Q9H4A5:GOLPH3L; NbExp=2; IntAct=EBI-524753, EBI-4403434; P51674:GPM6A; NbExp=5; IntAct=EBI-524753, EBI-7187133; P49840:GSK3A; NbExp=3; IntAct=EBI-524753, EBI-1044067; P42858:HTT; NbExp=12; IntAct=EBI-524753, EBI-466029; Q8IY31-3:IFT20; NbExp=3; IntAct=EBI-524753, EBI-9091197; Q9NWB7:IFT57; NbExp=2; IntAct=EBI-524753, EBI-725672; O60259:KLK8; NbExp=3; IntAct=EBI-524753, EBI-3915857; Q14847-2:LASP1; NbExp=3; IntAct=EBI-524753, EBI-9088686; Q96CV9-2:OPTN; NbExp=2; IntAct=EBI-524753, EBI-9091423; Q08499-8:PDE4D; NbExp=2; IntAct=EBI-524753, EBI-9090666; O15530-4:PDPK1; NbExp=3; IntAct=EBI-524753, EBI-9087775; P27986-2:PIK3R1; NbExp=2; IntAct=EBI-524753, EBI-9090282; Q9UF11-4:PLEKHB1; NbExp=4; IntAct=EBI-524753, EBI-9089825; Q16537:PPP2R5E; NbExp=2; IntAct=EBI-524753, EBI-968374; Q96DA2:RAB39B; NbExp=3; IntAct=EBI-524753, EBI-9089467; Q15047-2:SETDB1; NbExp=3; IntAct=EBI-524753, EBI-9090795; Q8IVB4:SLC9A9; NbExp=2; IntAct=EBI-524753, EBI-9092184; O00161:SNAP23; NbExp=4; IntAct=EBI-524753, EBI-745000; P60880:SNAP25; NbExp=3; IntAct=EBI-524753, EBI-524785; Q7Z699:SPRED1; NbExp=3; IntAct=EBI-524753, EBI-5235340; Q7Z698:SPRED2; NbExp=3; IntAct=EBI-524753, EBI-7082156; Q9C004:SPRY4; NbExp=2; IntAct=EBI-524753, EBI-354861; Q8NFA0:USP32; NbExp=2; IntAct=EBI-524753, EBI-2511075; Q9Y6W5:WASF2; NbExp=2; IntAct=EBI-524753, EBI-4290615; |
| Miscellaneous | The early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus. |
| Ptm | Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport. |
| Sequence Caution | Sequence=AAF28972.1; Type=Frameshift; Positions=183, 191; Evidence= ; Sequence=AAH30990.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAA76790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. |
| Similarity | Contains 1 DHHC-type zinc finger. |
| Similarity | Contains 5 ANK repeats. {ECO |
| Subcellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. |
| Subunit | Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease. |
| Tissue Specificity | Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000351 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 103471993 | RefSeq | NP_056151 | 632 | palmitoyltransferase ZDHHC17 |
Identical Sequences to LMP000351 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:103471993 | GenBank | JAB47698.1 | 632 | palmitoyltransferase ZDHHC17 [Callithrix jacchus] |
| GI:103471993 | GenBank | AIC50949.1 | 632 | ZDHHC17, partial [synthetic construct] |
| GI:103471993 | RefSeq | XP_005571659.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 isoform X2 [Macaca fascicularis] |
| GI:103471993 | RefSeq | XP_006737825.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 [Leptonychotes weddellii] |
| GI:103471993 | RefSeq | XP_008002278.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 isoform X2 [Chlorocebus sabaeus] |
| GI:103471993 | RefSeq | XP_002823585.3 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Pongo abelii] |
Related Sequences to LMP000351 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:103471993 | DBBJ | BAA76790.1 | 667 | KIAA0946 protein, partial [Homo sapiens] |
| GI:103471993 | RefSeq | XP_002711399.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 [Oryctolagus cuniculus] |
| GI:103471993 | RefSeq | XP_003783447.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 [Otolemur garnettii] |
| GI:103471993 | RefSeq | XP_003927869.1 | 795 | PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Saimiri boliviensis boliviensis] |
| GI:103471993 | RefSeq | XP_006142915.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 [Tupaia chinensis] |
| GI:103471993 | RefSeq | XP_006876577.1 | 632 | PREDICTED: palmitoyltransferase ZDHHC17 [Chrysochloris asiatica] |