Gene/Proteome Database (LMPD)

LMPD ID
LMP000315
Gene ID
13122
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 7, subfamily a, polypeptide 1
Gene Symbol
Cyp7a1
Synonyms
-
Alternate Names
cholesterol 7-alpha-monooxygenase; CYPVII; cytochrome P450 7A1; cytochrome P450, 7a1; cholesterol 7 alpha hydroxylase; cholesterol 7-alpha-hydroxylase
Chromosome
4
Map Location
4 A1|4
EC Number
1.14.13.17

Proteins

cholesterol 7-alpha-monooxygenase
Refseq ID NP_031850
Protein GI 31542445
UniProt ID Q64505
mRNA ID NM_007824
Length 503
RefSeq Status PROVISIONAL
MMSISLIWGIAVVVSCCIWFIIGIRRRKVGEPPLDNGLIPYLGCALKFGSNPLEFLRAKQRKHGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHYTTSAKAFGHRSIDPSDGNTTENINKTFNKTLQGDALCSLSEAMMQNLQSVMRPPGLPKSKSAVWVTEGMYAFCYRVMFEAGYLTLFGKDISKTDSQRAFIQNNLDSFKQFDQVFPALVAGVPIHLFKTAHKARERLAESLKHKNLYMRDQVSELIRLRMFLNDTLSTFDDMEKAKTHLVILWASQANTIPATFWSLFQMIRSPEAMKAASEEVNGALQSAGQELSSGGNAIYLDQEQLNNLPVLDSIIKEALRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDESGKAKTTFYRNGNKLKYFYMPFGSGATICPGRLFAVQEIKQFLILMLSYFELELVESHTKCPPLDQSRAGLGILPPLNDIEFKYKLKH

Gene Information

Entrez Gene ID
13122
Gene Name
cytochrome P450, family 7, subfamily a, polypeptide 1
Gene Symbol
Cyp7a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0008123 ISS:UniProtKB F cholesterol 7-alpha-monooxygenase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0006699 ISS:UniProtKB P bile acid biosynthetic process
GO:0071397 ISS:UniProtKB P cellular response to cholesterol
GO:0071333 ISS:UniProtKB P cellular response to glucose stimulus
GO:0006707 ISS:UniProtKB P cholesterol catabolic process
GO:0042632 ISS:UniProtKB P cholesterol homeostasis
GO:0070859 TAS:BHF-UCL P positive regulation of bile acid biosynthetic process
GO:0070857 ISS:UniProtKB P regulation of bile acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04976 Bile secretion
mmu03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 7, subfamily a, polypeptide 1
Protein Entry
CP7A1_MOUSE
UniProt ID
Q64505
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Cholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:14522988}.
Induction Up-regulated by fasting, returns to ground state upon feeding. Up-regulated by experimentally induced diabetes. Down- regulated by insulin treatment. {ECO:0000269|PubMed:14522988, ECO:0000269|PubMed:17636037}.
Pathway Lipid metabolism; bile acid biosynthesis.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP000315 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31542445 RefSeq NP_031850 503 cholesterol 7-alpha-monooxygenase

Identical Sequences to LMP000315 proteins

Reference Database Accession Length Protein Name
GI:31542445 DBBJ BAC34033.1 503 unnamed protein product [Mus musculus]
GI:31542445 DBBJ BAC34123.1 503 unnamed protein product [Mus musculus]
GI:31542445 DBBJ BAC34131.1 503 unnamed protein product [Mus musculus]
GI:31542445 DBBJ BAC34150.1 503 unnamed protein product [Mus musculus]
GI:31542445 RefSeq XP_006537666.1 503 PREDICTED: cholesterol 7-alpha-monooxygenase isoform X1 [Mus musculus]
GI:31542445 SwissProt Q64505.2 503 RecName: Full=Cholesterol 7-alpha-monooxygenase; AltName: Full=CYPVII; AltName: Full=Cholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 7A1 [Mus musculus]

Related Sequences to LMP000315 proteins

Reference Database Accession Length Protein Name
GI:31542445 GenBank AAA40839.1 503 cholesterol 7-alpha-hydroxylase (EC 1.14.13.17) [Rattus norvegicus]
GI:31542445 GenBank AAA03649.1 503 cholesterol 7-alpha-hydroxylase [Rattus norvegicus]
GI:31542445 GenBank AAA68867.1 503 cholesterol 7-alpha-hydroxylase [Mus musculus]
GI:31542445 GenBank AAI30262.1 503 Cytochrome P450, family 7, subfamily a, polypeptide 1 [Mus musculus]
GI:31542445 GenBank EDL05690.1 503 cytochrome P450, family 7, subfamily a, polypeptide 1 [Mus musculus]
GI:31542445 SwissProt P18125.1 503 RecName: Full=Cholesterol 7-alpha-monooxygenase; AltName: Full=CYPVII; AltName: Full=Cholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 7A1 [Rattus norvegicus]