Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Heatmap of compactin/KLA time course data for lipid category ST (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Ch25h KLA  Compactin  Compactin+KLA cholesterol 25-hydroxylase (Ch25h), mRNA [NM_009890] KLA 0.98 0.99 1.10 1.36 1.09 1.06 1.15   Compactin 0.97 0.97 0.95 0.98 1.03 1.00 1.00   Compactin+KLA 1.02 0.95 1.05 1.32 1.12 1.00 0.97 Cyp51 KLA  Compactin  Compactin+KLA cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.08 1.27 1.30 0.81 0.89 0.84 0.73   Compactin 1.08 1.03 1.13 1.13 1.11 1.16 0.92   Compactin+KLA 1.12 1.18 1.56 0.94 0.78 0.83 0.89 Dhcr24 KLA  Compactin  Compactin+KLA 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA 1.09 0.93 0.92 0.50 0.53 0.48 0.24   Compactin 1.00 1.04 1.01 0.98 1.05 1.16 0.92   Compactin+KLA 1.03 0.95 1.03 0.50 0.49 0.41 0.29 Dhcr7 KLA  Compactin  Compactin+KLA 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA 1.11 1.07 0.83 0.43 0.67 0.99 1.16   Compactin 1.25 1.16 1.17 1.45 1.20 0.98 1.00   Compactin+KLA 1.26 1.02 0.83 0.49 0.70 1.00 1.21 Ebp KLA  Compactin  Compactin+KLA phenylalkylamine Ca2+ antagonist (emopamil) binding protein (Ebp), mRNA [NM_007898] KLA 1.18 1.17 1.04 0.95 0.71 0.82 0.91   Compactin 1.24 1.16 1.12 1.16 1.15 1.03 1.06   Compactin+KLA 1.14 0.90 1.04 1.08 0.76 0.73 1.18 Fdft1 KLA  Compactin  Compactin+KLA farnesyl diphosphate farnesyl transferase 1 (Fdft1), mRNA [NM_010191] KLA 1.14 1.06 1.10 1.01 1.07 1.04 1.05   Compactin 1.10 1.11 1.07 1.24 1.16 1.09 1.10   Compactin+KLA 1.10 1.06 1.19 1.17 1.23 1.12 1.24 Fdps KLA  Compactin  Compactin+KLA 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030492I17 product:farnesyl diphosphate synthetase, full insert sequence. [AK077979] KLA 1.03 0.76 0.50 0.41 0.63 0.72 0.55   Compactin 0.90 1.03 1.18 0.88 1.08 0.99 1.14   Compactin+KLA 0.98 0.84 0.61 0.59 0.73 0.58 0.65 Fdps KLA  Compactin  Compactin+KLA farnesyl diphosphate synthetase (Fdps), mRNA [NM_134469] KLA 0.98 0.85 0.85 0.75 0.72 0.70 0.80   Compactin 0.89 0.86 0.92 0.86 1.19 1.22 1.05   Compactin+KLA 0.89 0.87 0.88 0.85 0.99 0.90 1.14 Ggps1 KLA  Compactin  Compactin+KLA adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330064P13 product:geranylgeranyl diphosphate synthase 1, full insert sequence [AK138564] KLA 0.92 0.95 1.03 1.11 1.11 1.05 0.97   Compactin 0.97 1.07 1.02 1.04 1.03 1.00 1.18   Compactin+KLA 1.00 1.05 0.99 1.04 1.12 1.10 0.95 Ggps1 KLA  Compactin  Compactin+KLA geranylgeranyl diphosphate synthase 1 (Ggps1), mRNA [NM_010282] KLA 0.95 1.15 1.24 1.43 1.68 1.95 2.35   Compactin 0.94 1.07 1.05 1.05 0.93 0.98 1.10   Compactin+KLA 0.97 1.17 1.11 1.41 1.60 1.79 2.23 Hmgcr KLA  Compactin  Compactin+KLA 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 1.15 1.47 1.66 1.32 1.27 1.28 0.96   Compactin 1.09 1.04 1.04 1.14 0.99 1.06 0.88   Compactin+KLA 1.21 1.46 1.76 1.44 1.44 1.45 1.03 Hmgcs2 KLA  Compactin  Compactin+KLA 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA 1.01 1.03 0.95 1.02 1.04 1.01 0.96   Compactin 0.99 0.99 1.03 0.98 1.09 1.04 0.98   Compactin+KLA 1.03 1.04 1.04 0.95 1.00 1.02 0.98 Hsd17b7 KLA  Compactin  Compactin+KLA hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), mRNA [NM_010476] KLA 1.22 1.30 1.33 1.05 1.27 1.27 0.85   Compactin 1.08 1.09 1.04 1.11 1.13 1.08 1.15   Compactin+KLA 1.16 1.27 1.63 1.19 1.25 1.11 0.99 Idi1 KLA  Compactin  Compactin+KLA isopentenyl-diphosphate delta isomerase (Idi1), transcript variant 2, mRNA [NM_177960] KLA 1.03 1.26 1.28 1.10 0.88 0.84 0.55   Compactin 0.99 0.93 0.96 1.07 0.97 1.04 0.87   Compactin+KLA 1.05 1.12 1.42 1.18 0.93 0.69 0.59 Lss KLA  Compactin  Compactin+KLA adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA 1.11 0.91 0.72 0.56 0.68 0.73 0.55   Compactin 1.13 1.08 1.22 1.23 1.18 0.90 0.76   Compactin+KLA 1.15 0.91 0.80 0.75 0.67 0.53 0.48 Lss KLA  Compactin  Compactin+KLA lanosterol synthase (Lss), mRNA [NM_146006] KLA 1.03 0.98 1.00 0.77 1.02 1.22 1.09   Compactin 1.00 1.00 0.96 1.05 1.17 1.10 0.96   Compactin+KLA 1.00 0.93 1.11 0.89 0.97 1.05 1.14 Mvd KLA  Compactin  Compactin+KLA mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA 1.07 1.01 0.93 0.60 0.60 0.82 0.82   Compactin 1.35 1.12 1.18 1.54 1.52 1.16 0.89   Compactin+KLA 1.17 0.98 1.14 0.84 0.85 0.84 0.84 Mvk KLA  Compactin  Compactin+KLA mevalonate kinase (Mvk), mRNA [NM_023556] KLA 1.16 1.05 1.04 0.93 0.84 0.98 0.99   Compactin 1.22 1.09 1.18 1.35 1.17 1.11 0.89   Compactin+KLA 1.25 1.04 1.01 0.98 0.98 0.96 1.09 Nsdhl KLA  Compactin  Compactin+KLA activated spleen cDNA, RIKEN full-length enriched library, clone:F830111P16 product:unclassifiable, full insert sequence [AK156993] KLA 1.04 0.95 0.86 0.80 0.89 0.95 0.91   Compactin 1.02 1.01 1.04 0.97 1.07 0.94 1.03   Compactin+KLA 1.07 0.93 0.93 0.84 0.86 0.88 0.94 Nsdhl KLA  Compactin  Compactin+KLA NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA 1.18 1.05 1.16 0.95 0.89 0.95 0.90   Compactin 1.13 1.09 1.08 1.23 1.16 1.06 0.78   Compactin+KLA 1.12 0.99 1.12 1.03 1.19 0.95 0.97 Pmvk KLA  Compactin  Compactin+KLA phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA 0.95 0.97 1.02 0.87 0.87 1.08 1.24   Compactin 1.01 1.00 1.10 1.16 1.24 1.06 1.19   Compactin+KLA 0.97 1.01 1.15 0.98 1.14 1.35 1.61 Sc4mol KLA  Compactin  Compactin+KLA sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA 0.95 1.13 1.08 0.60 0.90 1.07 0.94   Compactin 0.89 0.92 0.90 0.92 0.89 1.07 1.28   Compactin+KLA 0.98 0.95 1.10 0.78 1.00 1.18 1.30 Sc5d KLA  Compactin  Compactin+KLA 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830073K23 product:unclassifiable, full insert sequence [AK080673] KLA 1.21 1.09 0.67 0.62 0.58 0.64 0.62   Compactin 1.03 1.00 1.23 1.15 1.03 0.89 0.92   Compactin+KLA 1.23 1.02 0.83 0.68 0.55 0.59 0.60 Sc5d KLA  Compactin  Compactin+KLA sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d), mRNA [NM_172769] KLA 1.04 1.20 1.17 0.97 1.00 1.16 1.62   Compactin 0.97 1.05 1.02 1.13 0.92 0.99 1.09   Compactin+KLA 0.97 1.15 1.30 1.12 0.98 1.16 1.58 Soat1 KLA  Compactin  Compactin+KLA sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA 1.12 1.06 1.00 1.03 1.12 1.07 1.21   Compactin 1.13 1.06 1.09 0.99 0.90 0.85 0.69   Compactin+KLA 1.13 1.01 1.02 0.98 0.85 0.87 1.19 Soat2 KLA  Compactin  Compactin+KLA sterol O-acyltransferase 2 (Soat2), mRNA [NM_146064] KLA 0.92 1.00 1.00 0.99 1.47 2.00 1.59   Compactin 0.86 0.98 0.97 1.03 1.08 0.86 1.75   Compactin+KLA 0.99 0.89 1.03 1.08 1.66 2.18 1.56 Sqle KLA  Compactin  Compactin+KLA squalene epoxidase (Sqle), mRNA [NM_009270] KLA 0.96 1.04 1.06 0.53 0.74 0.79 0.98   Compactin 1.04 0.93 0.97 1.22 1.06 1.14 1.09   Compactin+KLA 1.07 1.04 0.96 0.65 0.89 0.96 1.00 Tm7sf2 KLA  Compactin  Compactin+KLA transmembrane 7 superfamily member 2 (Tm7sf2), mRNA [NM_028454] KLA 1.05 0.93 0.94 0.78 0.64 0.64 1.03   Compactin 1.07 1.07 1.12 1.22 1.10 1.29 1.25   Compactin+KLA 1.10 0.87 1.00 0.92 0.84 0.69 1.18