Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Heatmap of compactin/KLA time course data for lipid category SP (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Asah1 KLA  Compactin  Compactin+KLA N-acylsphingosine amidohydrolase 1 (Asah1), mRNA [NM_019734] KLA 1.19 0.93 1.00 0.93 0.88 1.00 1.10   Compactin 1.11 0.96 1.08 1.09 1.04 0.90 0.89   Compactin+KLA 1.17 0.98 0.94 0.91 0.86 1.02 1.07 Cerk KLA  Compactin  Compactin+KLA ceramide kinase (Cerk), mRNA [NM_145475] KLA 0.95 0.92 0.79 0.53 0.68 0.84 0.95   Compactin 1.01 0.97 0.94 1.00 0.92 0.80 0.71   Compactin+KLA 0.95 0.95 0.74 0.57 0.68 0.90 0.91 Degs1 KLA  Compactin  Compactin+KLA degenerative spermatocyte homolog 1 (Drosophila) (Degs1), mRNA [NM_007853] KLA 0.93 0.95 1.02 1.31 1.38 1.07 0.70   Compactin 0.91 0.77 0.77 0.84 1.09 1.23 1.21   Compactin+KLA 0.96 0.89 1.03 1.12 1.27 1.13 0.93 Degs2 KLA  Compactin  Compactin+KLA degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase (Degs2), mRNA [NM_027299] KLA 1.02 0.99 1.00 1.07 0.96 0.93 0.97   Compactin 0.98 0.92 1.00 1.00 0.97 0.98 0.99   Compactin+KLA 0.96 0.99 1.04 0.92 1.05 1.15 0.98 Kdsr KLA  Compactin  Compactin+KLA 3-ketodihydrosphingosine reductase (Kdsr), mRNA [NM_027534] KLA 0.98 1.00 0.95 0.73 0.55 0.55 0.33   Compactin 1.03 0.97 1.04 1.17 1.06 0.94 0.79   Compactin+KLA 1.08 0.98 0.91 0.68 0.55 0.47 0.27 Kdsr KLA  Compactin  Compactin+KLA 3-ketodihydrosphingosine reductase KLA 0.98 0.97 0.90 0.77 0.71 0.57 0.39   Compactin 1.08 1.04 1.07 1.03 1.02 0.92 0.92   Compactin+KLA 1.04 0.99 0.90 0.78 0.68 0.59 0.37 Lass2 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA 0.95 0.99 1.03 1.00 0.98 1.22 1.14   Compactin 1.06 1.03 1.02 1.01 0.95 1.18 1.11   Compactin+KLA 1.05 0.98 0.98 0.94 1.12 1.45 1.24 Lass4 KLA  Compactin  Compactin+KLA 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630036I10 product:longevity assurance homolog 4 (S. cerevisiae), full insert sequence. [AK036108] KLA 0.91 0.93 1.12 1.07 1.16 1.21 1.11   Compactin 1.02 1.05 1.00 0.99 1.00 1.00 1.07   Compactin+KLA 0.94 0.97 1.07 0.97 1.11 1.24 1.17 Lass4 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 4 (Lass4), mRNA [NM_026058] KLA 0.94 0.99 1.23 1.59 2.23 2.32 2.71   Compactin 0.94 0.98 1.02 0.97 0.88 0.95 1.21   Compactin+KLA 1.00 0.96 1.26 1.46 1.88 2.37 2.65 Lass5 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA 1.00 1.06 1.13 1.15 1.03 0.81 0.64   Compactin 1.12 1.08 1.00 1.15 1.16 1.11 1.14   Compactin+KLA 1.14 1.06 1.15 1.05 1.04 0.96 0.66 Lass6 KLA  Compactin  Compactin+KLA adult male colon cDNA, RIKEN full-length enriched library, clone:9030601N10 product:unclassifiable, full insert sequence [AK136463] KLA 0.98 0.88 1.08 1.52 0.86 0.76 0.73   Compactin 0.99 0.97 0.82 0.79 1.09 0.87 1.01   Compactin+KLA 0.90 1.13 0.87 1.43 1.08 1.09 1.03 Lass6 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 6 (Lass6), mRNA [NM_172856] KLA 1.14 1.29 1.45 1.99 1.93 1.51 1.19   Compactin 1.09 1.04 0.93 1.04 0.99 0.98 1.18   Compactin+KLA 1.18 1.22 1.31 2.16 2.18 1.48 1.33 Ppap2a KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 1.02 1.10 1.18 1.32 1.46 1.43 1.53   Compactin 1.20 1.18 1.08 1.18 1.03 0.99 1.32   Compactin+KLA 1.18 1.16 1.17 1.19 1.31 1.49 1.57 Ppap2b KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 0.97 1.03 1.01 0.97 0.93 0.90 1.03   Compactin 0.90 0.87 0.96 1.02 1.10 1.01 0.93   Compactin+KLA 0.97 0.91 0.97 0.95 0.97 0.92 1.02 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c KLA 1.09 1.07 1.14 1.11 0.96 1.04 0.87   Compactin 1.12 1.17 1.19 1.23 0.89 1.11 1.33   Compactin+KLA 1.15 1.03 1.10 1.16 1.07 1.06 0.89 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA 0.97 1.02 1.10 1.05 0.99 0.94 0.88   Compactin 1.03 1.02 0.95 0.92 0.97 1.13 1.13   Compactin+KLA 0.97 1.04 1.07 0.93 1.01 1.10 0.96 Sgms1 KLA  Compactin  Compactin+KLA sphingomyelin synthase 1 KLA 1.06 1.37 1.10 1.01 1.38 1.21 0.88   Compactin 0.91 0.87 1.06 0.87 1.26 1.98 2.23   Compactin+KLA 0.98 1.13 1.63 1.11 1.33 1.51 0.90 Sgms1 KLA  Compactin  Compactin+KLA sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA 0.90 1.29 1.06 0.72 1.26 1.04 1.01   Compactin 1.03 0.88 0.85 0.77 1.29 1.95 2.06   Compactin+KLA 0.79 1.23 1.30 0.88 1.20 1.50 1.06 Sgpl1 KLA  Compactin  Compactin+KLA sphingosine phosphate lyase 1 (Sgpl1), mRNA [NM_009163] KLA 0.93 0.92 0.94 0.84 1.33 1.21 1.05   Compactin 0.89 0.93 0.82 0.78 0.88 0.81 0.62   Compactin+KLA 0.93 0.92 0.85 0.71 1.05 1.32 0.92 Smpd1 KLA  Compactin  Compactin+KLA sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1), mRNA [NM_011421] KLA 0.74 0.73 0.71 0.78 1.18 1.04 1.02   Compactin 0.99 0.95 0.65 0.78 1.03 1.19 1.29   Compactin+KLA 0.76 0.90 0.66 0.63 1.04 1.54 1.12 Sphk1 KLA  Compactin  Compactin+KLA sphingosine kinase 1 (Sphk1), transcript variant 2, mRNA [NM_025367] KLA 1.01 0.96 1.09 1.25 1.12 1.01 0.97   Compactin 0.98 0.99 0.97 0.98 1.01 0.98 1.03   Compactin+KLA 0.98 0.98 1.07 1.01 1.08 1.12 1.07 Sphk2 KLA  Compactin  Compactin+KLA sphingosine kinase 2 (Sphk2), transcript variant 2, mRNA [NM_020011] KLA 0.91 0.88 0.75 1.05 2.20 2.16 1.61   Compactin 0.94 0.97 0.87 0.86 0.94 0.97 1.43   Compactin+KLA 0.99 0.94 0.79 0.91 2.14 2.01 1.21 Sptlc1 KLA  Compactin  Compactin+KLA serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), mRNA [NM_009269] KLA 1.10 1.16 1.31 1.36 1.12 1.23 0.79   Compactin 1.23 1.08 1.09 1.16 0.96 1.06 1.15   Compactin+KLA 1.23 1.16 1.28 1.28 1.19 1.13 0.69 Sptlc2 KLA  Compactin  Compactin+KLA serine palmitoyltransferase, long chain base subunit 2 (Sptlc2), mRNA [NM_011479] KLA 0.97 0.96 0.99 1.30 1.78 1.64 1.93   Compactin 1.06 1.01 0.99 0.93 1.03 1.04 0.99   Compactin+KLA 1.03 1.02 0.99 1.20 1.64 1.87 2.07 Ugcg KLA  Compactin  Compactin+KLA UDP-glucose ceramide glucosyltransferase, mRNA (cDNA clone MGC:59317 IMAGE:6512920), complete cds [BC050828] KLA 1.09 1.00 1.43 2.06 1.65 1.16 0.87   Compactin 0.97 0.90 0.83 0.83 0.92 1.25 1.26   Compactin+KLA 0.90 1.11 1.35 1.44 1.31 1.29 0.75 Ugcg KLA  Compactin  Compactin+KLA UDP-glucose ceramide glucosyltransferase (Ugcg), mRNA [NM_011673] KLA 1.05 1.44 1.32 1.77 1.74 1.43 1.05   Compactin 1.05 1.00 0.96 0.94 0.94 1.01 1.20   Compactin+KLA 1.02 1.26 1.43 1.60 1.40 1.20 1.07 Ugt8a KLA  Compactin  Compactin+KLA UDP galactosyltransferase 8A (Ugt8a), mRNA [NM_011674] KLA 1.02 1.00 1.04 0.97 0.98 1.02 1.04   Compactin 0.94 1.00 0.98 0.96 0.96 1.01 0.96   Compactin+KLA 0.96 1.01 1.04 0.96 1.02 1.02 0.99