Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Introduction | Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Heatmap of compactin/KLA time course data for lipid category FC (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Acaa1a KLA  Compactin  Compactin+KLA acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 1.13 0.97 1.00 0.94 0.84 0.80 0.44   Compactin 1.14 1.06 1.04 1.15 1.08 1.21 0.84   Compactin+KLA 1.08 1.02 0.93 0.88 0.90 0.76 0.43 Acox1 KLA  Compactin  Compactin+KLA acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA 0.90 0.94 0.91 0.79 1.27 1.21 1.18   Compactin 0.97 1.05 1.03 1.04 1.02 1.01 0.97   Compactin+KLA 1.00 0.90 0.90 0.85 1.18 1.34 1.41 Acox3 KLA  Compactin  Compactin+KLA acyl-Coenzyme A oxidase 3, pristanoyl KLA 0.74 0.84 0.60 0.64 0.65 0.57 0.66   Compactin 0.82 0.91 0.91 0.91 0.94 0.95 0.78   Compactin+KLA 1.04 0.86 0.63 0.62 0.51 0.51 0.79 Acox3 KLA  Compactin  Compactin+KLA acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA 0.88 0.82 0.71 0.69 0.57 0.62 0.84   Compactin 0.84 0.87 0.99 1.04 1.06 1.01 0.87   Compactin+KLA 0.96 0.78 0.67 0.67 0.58 0.63 0.78 Elovl2 KLA  Compactin  Compactin+KLA elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), mRNA [NM_019423] KLA 1.03 1.07 0.97 0.97 0.95 0.99 0.97   Compactin 0.99 1.06 1.02 0.95 1.09 1.05 0.97   Compactin+KLA 1.01 1.02 0.99 1.08 1.03 1.01 1.00 Elovl5 KLA  Compactin  Compactin+KLA ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA 1.07 1.01 1.01 0.66 0.56 0.69 0.73   Compactin 1.09 1.04 1.16 1.14 1.03 1.19 1.27   Compactin+KLA 1.14 0.98 1.01 0.61 0.56 0.73 0.68 Elovl6 KLA  Compactin  Compactin+KLA ELOVL family member 6, elongation of long chain fatty acids (yeast) KLA 0.96 1.05 0.62 0.45 0.36 0.33 0.42   Compactin 0.91 1.01 0.87 0.91 1.08 1.02 0.84   Compactin+KLA 0.89 0.98 0.63 0.43 0.27 0.31 0.55 Elovl6 KLA  Compactin  Compactin+KLA ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA [NM_130450] KLA 1.08 0.99 0.82 0.46 0.34 0.39 0.48   Compactin 1.17 1.18 1.18 1.21 1.01 1.03 1.00   Compactin+KLA 1.14 1.01 0.86 0.49 0.32 0.28 0.41 Fads1 KLA  Compactin  Compactin+KLA fatty acid desaturase 1 (Fads1), mRNA [NM_146094] KLA 1.06 0.96 0.91 0.75 0.54 0.57 0.77   Compactin 1.18 1.05 1.05 1.23 0.81 0.85 0.87   Compactin+KLA 1.17 0.87 1.17 0.77 0.49 0.49 0.83 Fads2 KLA  Compactin  Compactin+KLA fatty acid desaturase 2 (Fads2), mRNA [NM_019699] KLA 1.05 0.98 1.10 0.90 0.70 0.54 0.73   Compactin 1.06 1.15 1.12 1.07 0.85 0.98 0.74   Compactin+KLA 1.14 1.01 1.21 1.03 0.68 0.54 0.96 Fasn KLA  Compactin  Compactin+KLA fatty acid synthase (Fasn), mRNA [NM_007988] KLA 1.18 1.26 1.23 0.76 0.69 0.52 0.35   Compactin 1.12 1.07 1.10 1.03 0.99 0.99 0.73   Compactin+KLA 1.25 1.14 1.15 0.75 0.53 0.40 0.30 Hadha KLA  Compactin  Compactin+KLA 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA 0.89 1.00 1.07 0.99 1.03 1.07 0.90   Compactin 1.06 1.02 0.98 0.99 1.07 0.99 0.98   Compactin+KLA 0.96 1.06 0.99 1.06 1.00 0.97 0.92 Hadha KLA  Compactin  Compactin+KLA hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.06 0.93 0.90 1.16 1.03 1.08 1.51   Compactin 1.08 0.95 0.94 0.94 1.05 1.07 0.92   Compactin+KLA 0.95 1.02 0.94 0.98 1.08 1.21 1.59 Pla2g1b KLA  Compactin  Compactin+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.05 1.00 0.97 0.93 1.00 1.00 1.08   Compactin 1.20 1.03 1.05 0.98 1.01 1.00 0.96   Compactin+KLA 0.93 1.01 0.95 1.04 1.02 0.94 1.00 Pla2g4a KLA  Compactin  Compactin+KLA phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 1.18 1.06 0.78 0.84 1.83 1.58 1.41   Compactin 1.04 1.06 1.01 1.01 1.15 1.29 1.30   Compactin+KLA 1.12 1.09 0.89 0.90 1.53 2.04 2.00 Pla2g4b KLA  Compactin  Compactin+KLA phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 0.97 0.84 0.86 1.18 1.06 1.25 1.29   Compactin 0.96 0.98 1.05 1.00 1.12 1.02 1.08   Compactin+KLA 0.99 0.89 0.82 1.33 1.17 1.21 1.21 Pla2g5 KLA  Compactin  Compactin+KLA phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA 0.95 1.62 2.03 2.68 3.75 5.56 13.25   Compactin 0.93 1.02 1.03 0.90 0.78 0.87 1.96   Compactin+KLA 0.97 1.54 1.90 2.87 3.37 5.78 11.04 Pla2g6 KLA  Compactin  Compactin+KLA phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA 0.84 1.27 1.16 0.93 1.74 1.51 1.31   Compactin 0.90 0.92 0.96 0.88 0.94 1.08 1.04   Compactin+KLA 0.93 1.32 1.26 1.02 1.39 1.50 1.26 Scd1 KLA  Compactin  Compactin+KLA stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA [NM_009127] KLA 1.09 1.06 1.01 0.69 0.49 0.49 0.77   Compactin 1.07 1.21 1.08 1.33 1.07 1.06 0.79   Compactin+KLA 1.22 1.02 0.89 0.72 0.53 0.51 0.71 Scd2 KLA  Compactin  Compactin+KLA stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA [NM_009128] KLA 0.93 0.80 0.50 0.21 0.32 0.35 0.41   Compactin 1.01 0.88 0.93 0.90 0.79 0.82 0.64   Compactin+KLA 0.92 0.74 0.62 0.21 0.22 0.26 0.35 Scd3 KLA  Compactin  Compactin+KLA stearoyl-coenzyme A desaturase 3 (Scd3), mRNA [NM_024450] KLA 1.13 0.93 1.05 1.10 1.08 1.12 1.15   Compactin 1.01 0.96 1.01 0.99 1.08 1.08 1.01   Compactin+KLA 0.97 1.07 1.04 1.05 1.13 1.22 1.17 Tecr KLA  Compactin  Compactin+KLA trans-2,3-enoyl-CoA reductase KLA 1.34 1.26 1.27 1.02 0.96 0.92 1.10   Compactin 1.26 1.19 1.18 1.44 1.14 1.09 1.08   Compactin+KLA 1.26 1.13 1.18 1.05 1.07 0.84 0.95