Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Heatmap of compactin/KLA time course data for lipid category EM (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Alox5
KLA  Compactin  Compactin+KLA
arachidonate 5-lipoxygenase (Alox5), mRNA [NM_009662] KLA1.04 1.03 1.08 0.80 0.40 0.24 0.31
 Compactin1.13 1.02 1.15 1.14 1.67 2.21 2.90
 Compactin+KLA1.20 0.84 1.03 0.81 0.39 0.21 0.33
Pla2g1b
KLA  Compactin  Compactin+KLA
phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA1.05 1.00 0.97 0.93 1.00 1.00 1.08
 Compactin1.20 1.03 1.05 0.98 1.01 1.00 0.96
 Compactin+KLA0.93 1.01 0.95 1.04 1.02 0.94 1.00
Pla2g4a
KLA  Compactin  Compactin+KLA
phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA1.18 1.06 0.78 0.84 1.83 1.58 1.41
 Compactin1.04 1.06 1.01 1.01 1.15 1.29 1.30
 Compactin+KLA1.12 1.09 0.89 0.90 1.53 2.04 2.00
Pla2g4b
KLA  Compactin  Compactin+KLA
phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA0.97 0.84 0.86 1.18 1.06 1.25 1.29
 Compactin0.96 0.98 1.05 1.00 1.12 1.02 1.08
 Compactin+KLA0.99 0.89 0.82 1.33 1.17 1.21 1.21
Pla2g5
KLA  Compactin  Compactin+KLA
phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA0.95 1.62 2.03 2.68 3.75 5.56 13.25
 Compactin0.93 1.02 1.03 0.90 0.78 0.87 1.96
 Compactin+KLA0.97 1.54 1.90 2.87 3.37 5.78 11.04
Pla2g6
KLA  Compactin  Compactin+KLA
phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA0.84 1.27 1.16 0.93 1.74 1.51 1.31
 Compactin0.90 0.92 0.96 0.88 0.94 1.08 1.04
 Compactin+KLA0.93 1.32 1.26 1.02 1.39 1.50 1.26
Ptgds
KLA  Compactin  Compactin+KLA
prostaglandin D2 synthase (brain) (Ptgds), mRNA [NM_008963] KLA1.11 1.02 1.13 1.28 1.05 1.07 0.98
 Compactin1.04 1.00 1.16 1.08 1.10 1.07 1.09
 Compactin+KLA1.01 1.06 1.17 1.16 1.12 1.11 0.88
Ptges
KLA  Compactin  Compactin+KLA
prostaglandin E synthase (Ptges), mRNA [NM_022415] KLA0.89 1.64 1.98 2.68 3.48 4.51 7.67
 Compactin0.84 0.91 0.92 0.92 1.04 1.11 1.29
 Compactin+KLA0.91 1.46 1.94 2.37 3.09 5.56 7.88
Ptgs1
KLA  Compactin  Compactin+KLA
prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] KLA0.94 1.11 1.04 0.87 0.97 0.92 0.97
 Compactin0.85 1.06 1.14 1.02 1.11 1.28 2.13
 Compactin+KLA0.95 1.02 1.03 1.01 0.90 0.99 1.05
Ptgs2
KLA  Compactin  Compactin+KLA
prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] KLA1.71 5.67 12.17 46.29 77.95 86.42 105.26
 Compactin0.78 0.86 1.03 0.82 0.90 0.97 2.25
 Compactin+KLA1.55 5.50 11.35 45.69 81.03 135.77 153.55