Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Proximal tubule bicarbonate reclamation (mmu04964)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
AK078587	KLA Compactin Compactin+KLA	AK078587	11 days embryo gonad cDNA, RIKEN full-length enriched library, clone:7030411M21 product:unclassifiable, full insert sequence [AK078587]	KLA	1.150	1.050	0.980	0.960	1.050	0.980	1.000
				Compactin	0.960	1.030	0.920	0.930	0.970	1.000	1.100
				KLA/Compactin	1.050	0.960	1.080	1.010	0.960	1.000	1.050

Aqp1	KLA Compactin Compactin+KLA	NM_007472		aquaporin 1 (Aqp1), mRNA [NM_007472]	KLA	0.970	1.010	0.960	0.970	1.170	1.060	1.020
					Compactin	0.930	1.010	0.940	1.030	1.100	1.170	1.610
					KLA/Compactin	0.930	1.020	1.010	0.990	0.890	0.980	1.030

Aqp1	KLA Compactin Compactin+KLA	NM_007472	aquaporin 1 (Aqp1), mRNA [NM_007472]	KLA	0.990	0.920	0.960	0.970	0.990	0.970	0.990
				Compactin	1.000	1.000	0.950	1.000	1.120	1.230	1.450
				KLA/Compactin	0.970	1.050	1.060	0.990	1.040	1.010	1.070

Atp1a1	KLA Compactin Compactin+KLA	NM_144900		ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900]	KLA	0.960	0.910	0.950	0.830	0.730	0.700	0.720
					Compactin	0.930	0.790	0.960	0.810	0.870	0.690	0.870
					KLA/Compactin	0.950	0.870	0.860	0.600	1.020	0.650	0.610

Atp1a1	KLA Compactin Compactin+KLA	NM_144900	ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900]	KLA	0.980	0.840	0.910	0.770	0.720	0.590	0.560
				Compactin	0.960	0.910	0.850	0.730	0.920	0.660	0.940
				KLA/Compactin	0.960	0.930	0.720	0.690	0.940	0.850	0.640

Atp1a2	KLA Compactin Compactin+KLA	NM_178405		ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2), mRNA [NM_178405]	KLA	0.950	1.020	0.980	1.010	0.920	1.000	1.070
					Compactin	0.950	0.930	0.940	1.030	0.980	0.990	0.990
					KLA/Compactin	1.000	0.940	1.080	1.010	1.030	0.960	0.980

Atp1a3	KLA Compactin Compactin+KLA	AK053751	0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751]	KLA	0.740	0.690	0.770	0.720	0.820	0.900	0.870
				Compactin	1.040	1.040	1.010	1.040	1.040	0.970	1.000
				KLA/Compactin	0.810	0.660	0.850	0.690	0.840	0.910	0.920

Atp1a3	KLA Compactin Compactin+KLA	AK053751		0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751]	KLA	0.760	0.730	0.760	0.740	0.820	0.980	0.890
					Compactin	1.060	1.040	1.010	1.010	1.040	0.980	0.950
					KLA/Compactin	0.880	0.730	0.810	0.750	0.860	0.840	0.990

Atp1a3	KLA Compactin Compactin+KLA	NM_144921	ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), mRNA [NM_144921]	KLA	1.100	0.950	0.880	0.680	0.640	0.460	0.520
				Compactin	0.920	1.130	0.990	0.820	1.110	1.220	0.990
				KLA/Compactin	1.070	0.940	0.900	0.620	0.470	0.480	0.740

Atp1b1	KLA Compactin Compactin+KLA	NM_009721		ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA [NM_009721]	KLA	0.930	0.910	0.990	1.020	0.990	1.040	1.020
					Compactin	1.030	0.990	1.020	1.000	0.990	1.020	1.000
					KLA/Compactin	1.000	1.100	0.970	0.990	1.070	1.050	1.080

Atp1b2	KLA Compactin Compactin+KLA	NM_013415	ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2), mRNA [NM_013415]	KLA	1.020	0.980	1.130	2.140	1.750	1.710	2.070
				Compactin	0.940	0.950	0.940	1.020	0.950	1.060	1.110
				KLA/Compactin	0.950	1.010	1.070	1.760	1.990	2.210	2.040

Atp1b3	KLA Compactin Compactin+KLA	NM_007502		ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502]	KLA	0.880	0.990	1.000	0.980	1.430	1.790	1.730
					Compactin	0.840	0.890	0.950	0.960	0.990	1.150	1.240
					KLA/Compactin	0.920	1.050	0.950	1.190	1.370	1.620	2.300

Atp1b3	KLA Compactin Compactin+KLA	NM_007502	ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502]	KLA	1.220	1.220	1.210	1.300	1.400	1.780	1.500
				Compactin	1.140	1.150	1.080	1.020	1.060	1.060	1.200
				KLA/Compactin	1.180	1.060	1.270	1.410	1.470	1.570	1.660

Atp1b3	KLA Compactin Compactin+KLA	NM_007502		ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502]	KLA	1.310	1.150	1.370	1.310	1.680	1.850	1.920
					Compactin	1.290	1.200	1.070	1.240	1.060	1.250	1.130
					KLA/Compactin	1.140	1.220	1.290	1.380	1.780	1.650	2.140

Atp1b4	KLA Compactin Compactin+KLA	NM_133690	ATPase, (Na+)/K+ transporting, beta 4 polypeptide (Atp1b4), mRNA [NM_133690]	KLA	0.990	0.980	1.020	1.060	1.020	1.050	1.030
				Compactin	1.040	0.960	1.040	1.010	0.990	0.960	1.000
				KLA/Compactin	0.940	0.950	1.050	1.020	1.000	1.050	1.000

Fxyd2	KLA Compactin Compactin+KLA	NM_052823		FXYD domain-containing ion transport regulator 2 (Fxyd2), transcript variant b, mRNA [NM_052823]	KLA	0.760	0.880	0.680	0.880	0.870	0.580	0.320
					Compactin	0.800	0.850	1.010	0.720	1.100	1.430	0.840
					KLA/Compactin	0.940	0.950	0.810	0.740	0.710	0.590	0.400

Gls	KLA Compactin Compactin+KLA	164607131	glutaminase	KLA	0.920	0.900	0.780	0.580	0.610	0.700	0.370
				Compactin	0.830	0.890	0.830	0.930	0.950	1.020	1.120
				KLA/Compactin	0.840	0.930	0.800	0.460	0.690	0.520	0.300

Gls	KLA Compactin Compactin+KLA	NM_001081081		glutaminase (Gls), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_001081081]	KLA	0.910	1.010	1.070	0.990	1.130	1.100	0.820
					Compactin	0.990	1.000	1.030	1.000	1.020	1.080	1.020
					KLA/Compactin	1.010	1.050	0.990	0.850	1.110	1.080	0.850

Gls	KLA Compactin Compactin+KLA	NM_001113383	glutaminase (Gls), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA [NM_001113383]	KLA	0.920	1.170	1.430	1.410	0.890	0.720	0.550
				Compactin	0.880	0.910	0.970	0.880	0.930	1.000	0.980
				KLA/Compactin	0.830	1.040	1.260	1.460	0.980	0.590	0.480

Gls2	KLA Compactin Compactin+KLA	142348692		glutaminase 2 (liver, mitochondrial)	KLA	1.000	1.050	1.000	0.970	0.700	0.700	0.760
					Compactin	0.980	1.150	1.010	1.050	1.040	1.050	0.930
					KLA/Compactin	0.970	1.040	0.890	0.930	0.710	0.690	0.780

Gls2	KLA Compactin Compactin+KLA	NM_001033264	glutaminase 2 (liver, mitochondrial) (Gls2), nuclear gene encoding mitochondrial protein, mRNA [NM_001033264]	KLA	1.030	1.070	1.030	0.910	0.710	0.700	0.750
				Compactin	1.060	1.170	1.050	1.060	1.080	1.150	0.980
				KLA/Compactin	1.010	1.090	0.950	0.920	0.710	0.650	0.750

Glud1	KLA Compactin Compactin+KLA	NM_008133		glutamate dehydrogenase 1 (Glud1), mRNA [NM_008133]	KLA	1.230	1.100	1.150	0.870	0.830	0.720	0.640
					Compactin	1.110	1.150	1.270	1.190	1.390	1.190	1.310
					KLA/Compactin	1.210	0.920	1.040	0.850	0.910	0.860	0.580

Mdh1	KLA Compactin Compactin+KLA	AK077724	8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724]	KLA	0.770	0.750	0.810	0.650	0.850	0.880	0.910
				Compactin	1.040	1.050	1.010	0.960	1.050	0.860	1.060
				KLA/Compactin	0.760	0.710	0.790	0.700	0.820	0.800	0.880

Mdh1	KLA Compactin Compactin+KLA	NM_008618		malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618]	KLA	1.020	0.980	1.020	0.860	0.570	0.600	0.650
					Compactin	1.070	1.030	1.160	1.140	1.100	1.040	0.860
					KLA/Compactin	1.090	0.970	0.930	0.950	0.620	0.580	0.590

Mdh1	KLA Compactin Compactin+KLA	NM_008618	malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618]	KLA	1.050	1.000	0.780	0.770	0.870	0.550	0.560
				Compactin	0.960	1.040	1.100	0.890	1.170	1.150	1.060
				KLA/Compactin	0.810	0.900	0.920	0.790	0.570	0.490	0.710

Pck2	KLA Compactin Compactin+KLA	NM_028994		phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994]	KLA	1.000	0.860	0.820	0.670	1.380	1.490	0.930
					Compactin	0.880	1.110	1.140	1.080	1.200	1.130	1.170
					KLA/Compactin	0.880	0.980	0.820	1.030	1.380	1.550	1.200

Slc25a10	KLA Compactin Compactin+KLA	NM_013770	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 (Slc25a10), nuclear gene encoding mitochondrial protein, mRNA [NM_013770]	KLA	1.000	0.910	0.920	0.660	0.420	0.470	0.520
				Compactin	1.090	0.940	1.090	1.180	1.020	0.880	0.670
				KLA/Compactin	1.050	1.000	0.980	0.720	0.440	0.450	0.420

Slc38a3	KLA Compactin Compactin+KLA	34328321		solute carrier family 38, member 3	KLA	1.060	1.090	1.170	1.270	1.210	1.220	1.590
					Compactin	1.070	1.010	1.040	1.130	1.390	1.230	1.210
					KLA/Compactin	1.080	1.160	1.080	1.290	1.470	1.670	1.620

Slc38a3	KLA Compactin Compactin+KLA	NM_023805	solute carrier family 38, member 3 (Slc38a3), mRNA [NM_023805]	KLA	1.170	1.050	1.010	1.060	1.050	1.020	0.990
				Compactin	1.020	1.020	1.040	1.000	1.110	1.060	1.000
				KLA/Compactin	1.020	1.110	1.080	1.070	1.030	0.990	1.030

Slc4a4	KLA Compactin Compactin+KLA	NM_018760		solute carrier family 4 (anion exchanger), member 4 (Slc4a4), mRNA [NM_018760]	KLA	1.050	0.970	0.960	0.980	1.010	0.990	1.040
					Compactin	1.010	1.010	1.040	1.050	0.960	1.050	1.020
					KLA/Compactin	1.090	1.050	0.980	1.010	0.990	1.020	0.980

Slc4a4	KLA Compactin Compactin+KLA	NM_018760	solute carrier family 4 (anion exchanger), member 4 (Slc4a4), mRNA [NM_018760]	KLA	1.050	1.010	1.000	1.070	1.050	0.930	1.020
				Compactin	0.990	1.040	1.030	1.030	1.060	0.960	0.940
				KLA/Compactin	0.920	1.030	1.020	1.000	0.980	1.100	1.000

Slc9a3	KLA Compactin Compactin+KLA	AK033564		adult male colon cDNA, RIKEN full-length enriched library, clone:9030624O13 product:SODIUM [AK033564]	KLA	1.040	1.060	0.950	1.010	1.070	1.040	0.950
					Compactin	1.100	1.000	1.040	1.030	0.940	0.960	0.950
					KLA/Compactin	1.000	0.960	0.910	0.990	1.040	1.030	1.020

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Proximal tubule bicarbonate reclamation (mmu04964)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios