Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Phototransduction (mmu04744)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
Arrb1	KLA Compactin Compactin+KLA	NM_177231	arrestin, beta 1 (Arrb1), transcript variant a, mRNA [NM_177231]	KLA	0.920	1.030	0.870	0.640	0.580	0.720	0.740
				Compactin	0.980	0.970	0.930	0.850	1.080	1.380	0.960
				KLA/Compactin	0.810	1.050	1.070	0.670	0.620	0.650	0.830

Arrb1	KLA Compactin Compactin+KLA	NM_177231		arrestin, beta 1 (Arrb1), transcript variant a, mRNA [NM_177231]	KLA	1.340	1.010	0.900	0.370	0.310	0.310	0.230
					Compactin	1.040	1.310	1.300	1.140	1.080	1.060	0.770
					KLA/Compactin	1.320	1.020	0.810	0.430	0.300	0.300	0.210

Arrb2	KLA Compactin Compactin+KLA	146149233	arrestin, beta 2	KLA	0.980	1.020	1.050	0.960	1.310	1.420	1.050
				Compactin	1.070	1.040	1.040	1.160	0.970	1.000	1.220
				KLA/Compactin	1.040	0.950	1.090	1.060	1.330	1.200	1.040

Calm1	KLA Compactin Compactin+KLA	NM_009790		calmodulin 1 (Calm1), mRNA [NM_009790]	KLA	0.890	0.930	0.970	1.140	1.000	1.130	1.570
					Compactin	1.020	0.980	1.000	1.030	1.110	1.130	1.350
					KLA/Compactin	1.010	0.920	1.000	0.990	1.270	1.580	1.550

Calm1	KLA Compactin Compactin+KLA	NM_009790	calmodulin 1 (Calm1), mRNA [NM_009790]	KLA	1.040	1.110	1.070	1.240	0.900	0.700	0.570
				Compactin	1.160	1.130	1.050	1.180	1.050	1.180	1.320
				KLA/Compactin	1.100	1.030	1.040	1.130	0.910	0.740	0.600

Calm1	KLA Compactin Compactin+KLA	NM_009790		calmodulin 1 (Calm1), mRNA [NM_009790]	KLA	1.070	1.020	1.020	0.960	0.850	0.830	0.700
					Compactin	1.020	1.080	1.000	1.020	1.040	1.090	1.170
					KLA/Compactin	1.000	1.020	1.070	0.990	0.870	0.720	0.750

Calm2	KLA Compactin Compactin+KLA	NM_007589	calmodulin 2 (Calm2), mRNA [NM_007589]	KLA	0.830	0.890	0.910	0.870	0.800	0.750	0.640
				Compactin	0.880	0.970	0.970	0.870	0.950	1.060	1.240
				KLA/Compactin	0.860	0.830	0.960	0.900	0.730	0.740	0.620

Calm2	KLA Compactin Compactin+KLA	NM_007589		calmodulin 2 (Calm2), mRNA [NM_007589]	KLA	1.100	1.090	1.190	0.900	0.650	0.820	0.720
					Compactin	1.090	1.110	1.160	1.090	1.140	1.010	1.070
					KLA/Compactin	1.060	0.960	1.090	0.990	0.840	0.660	0.650

Calm3	KLA Compactin Compactin+KLA	NM_007590	calmodulin 3 (Calm3), mRNA [NM_007590]	KLA	0.880	0.930	0.970	1.050	1.150	1.280	1.660
				Compactin	0.840	1.010	0.990	0.940	0.940	1.090	1.150
				KLA/Compactin	0.890	0.910	0.940	1.160	1.080	1.260	1.910

Calm3	KLA Compactin Compactin+KLA	NM_007590		calmodulin 3 (Calm3), mRNA [NM_007590]	KLA	0.960	1.000	1.070	1.070	0.710	0.770	1.000
					Compactin	1.020	1.040	1.020	1.140	1.120	1.070	0.990
					KLA/Compactin	1.010	0.920	0.910	0.930	0.890	1.060	1.120

Calm3	KLA Compactin Compactin+KLA	NM_007590	calmodulin 3 (Calm3), mRNA [NM_007590]	KLA	1.260	1.230	1.170	1.130	0.920	0.950	1.000
				Compactin	1.170	1.300	1.350	1.150	0.840	1.090	1.090
				KLA/Compactin	1.140	1.020	1.160	1.310	1.020	0.880	1.080

Calm4	KLA Compactin Compactin+KLA	NM_020036		calmodulin 4 (Calm4), mRNA [NM_020036]	KLA	1.000	0.990	1.010	1.030	1.040	1.070	0.970
					Compactin	0.990	0.950	1.040	0.990	0.940	1.020	0.990
					KLA/Compactin	0.980	0.990	1.040	1.070	1.000	1.150	0.970

Calm4	KLA Compactin Compactin+KLA	NM_020036	calmodulin 4 (Calm4), mRNA [NM_020036]	KLA	1.020	0.980	1.030	1.060	1.010	0.960	0.950
				Compactin	0.960	1.040	1.040	0.990	0.990	1.020	0.990
				KLA/Compactin	0.940	0.970	1.130	1.030	0.970	1.080	0.980

Calm5	KLA Compactin Compactin+KLA	NM_001008706		calmodulin 5 (Calm5), mRNA [NM_001008706]	KLA	1.020	1.000	1.030	0.880	1.020	1.060	0.940
					Compactin	0.890	0.970	1.010	0.970	1.030	1.060	1.010
					KLA/Compactin	0.980	0.970	1.000	0.960	0.970	0.950	1.020

Calml3	KLA Compactin Compactin+KLA	NM_027416	calmodulin-like 3 (Calml3), mRNA [NM_027416]	KLA	0.940	1.010	0.960	1.020	0.970	1.020	1.060
				Compactin	1.010	1.020	1.010	1.010	1.000	0.970	1.050
				KLA/Compactin	0.980	1.030	1.000	1.080	1.020	1.040	1.020

Cnga1	KLA Compactin Compactin+KLA	U19717		cGMP-gated cation channel mRNA, clone mIMCD-K2 no.1, complete cds. [U19717]	KLA	1.070	0.990	1.060	1.010	0.980	1.030	0.980
					Compactin	0.960	0.990	1.000	0.950	0.990	1.010	1.030
					KLA/Compactin	0.920	0.990	1.000	1.070	1.100	0.950	1.000

Cngb1	KLA Compactin Compactin+KLA	BC045114	cyclic nucleotide gated channel beta 1, mRNA (cDNA clone IMAGE:4504353), partial cds [BC045114]	KLA	1.040	0.970	0.990	1.020	0.950	0.980	0.960
				Compactin	1.050	1.020	0.950	0.990	0.880	1.030	0.960
				KLA/Compactin	0.980	1.000	1.000	0.960	1.040	1.090	1.000

Gnat1	KLA Compactin Compactin+KLA	NM_008140		guanine nucleotide binding protein, alpha transducing 1 (Gnat1), mRNA [NM_008140]	KLA	0.990	0.910	0.970	1.080	0.990	0.900	1.040
					Compactin	1.020	0.940	1.020	0.970	1.000	1.040	0.980
					KLA/Compactin	1.000	1.030	0.980	0.980	1.020	1.050	0.990

Gnat1	KLA Compactin Compactin+KLA	NM_008140	guanine nucleotide binding protein, alpha transducing 1 (Gnat1), mRNA [NM_008140]	KLA	1.050	1.030	0.970	1.010	0.960	0.950	1.030
				Compactin	1.020	0.960	1.040	0.980	1.040	1.040	0.940
				KLA/Compactin	0.980	1.030	1.050	1.000	0.960	0.960	1.000

Gnat2	KLA Compactin Compactin+KLA	NM_008141		guanine nucleotide binding protein, alpha transducing 2 (Gnat2), mRNA [NM_008141]	KLA	0.980	1.010	0.970	0.930	0.800	0.860	0.770
					Compactin	1.110	1.000	1.080	1.060	1.040	0.990	1.080
					KLA/Compactin	1.020	1.110	1.040	1.000	0.820	0.800	0.820

Gnb1	KLA Compactin Compactin+KLA	NM_008142	guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142]	KLA	0.930	0.920	1.040	1.200	1.010	1.000	0.650
				Compactin	1.050	0.880	0.910	1.100	1.040	1.050	1.330
				KLA/Compactin	0.960	0.900	1.000	1.090	1.350	0.940	0.580

Gnb1	KLA Compactin Compactin+KLA	NM_008142		guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142]	KLA	1.010	1.120	1.140	1.250	1.360	1.800	2.870
					Compactin	1.170	1.110	1.160	1.230	0.990	1.150	1.500
					KLA/Compactin	1.100	1.020	1.150	1.290	1.670	1.950	3.230

Gnb1	KLA Compactin Compactin+KLA	NM_008142	guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142]	KLA	1.040	1.030	1.070	1.260	1.240	1.400	2.660
				Compactin	0.940	1.110	1.160	1.310	1.090	1.120	1.320
				KLA/Compactin	1.130	0.980	1.150	1.240	1.800	2.130	2.260

Gnb1	KLA Compactin Compactin+KLA	NM_008142		guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142]	KLA	1.350	1.220	1.090	1.160	1.440	1.640	2.010
					Compactin	1.090	1.190	1.320	1.170	1.350	1.010	1.290
					KLA/Compactin	1.310	1.020	1.230	1.480	1.510	1.790	2.630

Gngt1	KLA Compactin Compactin+KLA	NM_010314	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (Gngt1), mRNA [NM_010314]	KLA	0.970	1.000	0.910	1.050	1.020	1.000	1.010
				Compactin	0.990	1.050	0.950	0.960	0.990	0.990	2.020
				KLA/Compactin	0.990	1.000	1.000	1.060	1.000	1.070	1.050

Grk1	KLA Compactin Compactin+KLA	NM_011881		G protein-coupled receptor kinase 1 (Grk1), mRNA [NM_011881]	KLA	0.980	1.020	1.030	1.010	0.990	0.960	0.950
					Compactin	1.030	0.960	1.010	1.020	1.040	1.030	0.990
					KLA/Compactin	1.000	1.030	1.010	0.970	1.070	0.980	1.020

Guca1a	KLA Compactin Compactin+KLA	NM_008189	guanylate cyclase activator 1a (retina) (Guca1a), mRNA [NM_008189]	KLA	1.130	1.080	1.070	1.070	0.820	0.960	1.650
				Compactin	1.170	1.090	1.190	1.200	1.130	1.060	0.880
				KLA/Compactin	0.990	0.990	0.970	1.180	0.890	0.920	1.510

Guca1b	KLA Compactin Compactin+KLA	NM_146079		guanylate cyclase activator 1B (Guca1b), mRNA [NM_146079]	KLA	0.930	0.950	1.100	1.280	1.390	1.110	1.270
					Compactin	0.810	0.870	0.850	0.880	1.080	1.030	0.960
					KLA/Compactin	0.950	1.000	0.980	1.130	1.130	1.320	1.530

Gucy2e	KLA Compactin Compactin+KLA	BC057954	guanylate cyclase 2e, mRNA (cDNA clone MGC:68216 IMAGE:5360206), complete cds. [BC057954]	KLA	0.990	1.000	0.990	0.970	1.040	0.960	1.010
				Compactin	1.070	1.050	0.990	1.030	1.000	0.980	1.020
				KLA/Compactin	0.990	1.050	0.990	0.950	1.000	0.990	1.020

Gucy2e	KLA Compactin Compactin+KLA	NM_008192		guanylate cyclase 2e (Gucy2e), mRNA [NM_008192]	KLA	0.970	1.010	1.020	1.020	1.000	0.930	1.020
					Compactin	0.990	1.040	1.080	0.980	0.980	0.950	0.980
					KLA/Compactin	0.980	1.040	1.000	0.940	0.950	0.990	1.010

Gucy2e	KLA Compactin Compactin+KLA	NM_008192	guanylate cyclase 2e (Gucy2e), mRNA [NM_008192]	KLA	1.040	1.020	1.080	0.940	0.990	0.970	0.960
				Compactin	0.970	1.050	1.000	1.070	0.980	1.000	1.010
				KLA/Compactin	1.010	0.960	0.940	1.010	1.100	1.020	0.960

Gucy2f	KLA Compactin Compactin+KLA	NM_001007576		guanylate cyclase 2f (Gucy2f), mRNA [NM_001007576]	KLA	1.060	0.890	1.000	1.020	1.030	0.870	0.940
					Compactin	1.030	0.910	1.060	0.940	0.990	1.060	0.960
					KLA/Compactin	0.980	1.040	1.020	1.000	0.940	1.100	0.980

Pde6a	KLA Compactin Compactin+KLA	NM_146086	phosphodiesterase 6A, cGMP-specific, rod, alpha (Pde6a), mRNA [NM_146086]	KLA	0.980	0.990	1.070	0.980	0.980	1.010	0.990
				Compactin	0.980	1.030	1.010	0.980	0.960	1.020	1.010
				KLA/Compactin	1.000	1.010	1.080	0.960	1.000	1.030	1.050

Pde6b	KLA Compactin Compactin+KLA	NM_008806		phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide (Pde6b), mRNA [NM_008806]	KLA	0.990	0.960	0.950	0.990	1.020	1.090	1.010
					Compactin	1.030	0.930	0.960	1.000	0.960	0.980	0.960
					KLA/Compactin	1.000	1.010	1.020	0.940	0.950	0.960	1.000

Pde6g	KLA Compactin Compactin+KLA	NM_012065	phosphodiesterase 6G, cGMP-specific, rod, gamma (Pde6g), mRNA [NM_012065]	KLA	0.990	0.960	0.950	1.030	0.940	0.980	1.070
				Compactin	0.910	0.970	0.970	1.060	1.040	1.000	0.980
				KLA/Compactin	0.990	1.020	0.930	1.000	1.080	1.180	1.030

Rcvrn	KLA Compactin Compactin+KLA	162951841		recoverin	KLA	1.090	1.580	0.970	1.000	0.990	0.900	0.940
					Compactin	1.070	0.940	1.050	1.030	1.050	0.990	1.160
					KLA/Compactin	0.990	1.360	1.080	1.040	1.000	1.040	1.040

Rcvrn	KLA Compactin Compactin+KLA	X66196	gb\|M.musculus mRNA for 23 kDa photoreceptor cell-specific protein. [X66196]	KLA	1.100	1.530	1.080	0.970	1.030	0.990	0.970
				Compactin	1.050	1.000	1.000	1.010	1.030	1.030	1.070
				KLA/Compactin	0.980	1.510	1.030	1.030	1.120	0.900	0.940

Rgs9	KLA Compactin Compactin+KLA	NM_011268		regulator of G-protein signaling 9 (Rgs9), mRNA [NM_011268]	KLA	0.900	0.990	1.010	1.070	0.930	1.020	1.070
					Compactin	1.010	0.940	0.930	1.020	0.900	0.920	0.970
					KLA/Compactin	0.920	1.020	1.030	1.000	0.930	0.990	0.940

Rho	KLA Compactin Compactin+KLA	21717804	rhodopsin	KLA	1.060	1.020	0.980	0.930	1.050	1.070	0.980
				Compactin	1.020	0.950	0.980	1.010	0.910	1.030	1.070
				KLA/Compactin	1.020	0.960	1.020	1.050	1.030	0.990	1.030

Rho	KLA Compactin Compactin+KLA	NM_145383		rhodopsin (Rho), mRNA [NM_145383]	KLA	1.030	0.970	1.010	1.030	0.970	0.980	1.120
					Compactin	1.020	0.990	0.960	1.000	0.940	0.980	0.990
					KLA/Compactin	1.050	0.970	1.050	1.070	0.980	0.950	0.980

Slc24a1	KLA Compactin Compactin+KLA	NM_144813	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 (Slc24a1), mRNA [NM_144813]	KLA	0.960	0.930	0.930	1.000	1.030	1.040	1.040
				Compactin	1.050	1.030	1.050	0.990	1.030	0.960	1.040
				KLA/Compactin	1.010	0.980	0.980	1.020	1.100	1.030	1.060

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Phototransduction (mmu04744)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios