Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Renin-angiotensin system (mmu04614)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Ace
KLA  Compactin  Compactin+KLA
 J04947 gb|Mouse angiotensin-converting enzyme mRNA, 3 end, clone ACE.11. [J04947] KLA1.090 0.990 0.860 1.040 0.940 0.980 0.980
Compactin1.080 0.980 1.030 0.960 1.050 0.980 1.100
KLA/Compactin0.980 1.000 0.960 1.040 0.950 1.060 1.030
Ace
KLA  Compactin  Compactin+KLA
 NM_009598 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (Ace), transcript variant 2, mRNA [NM_009598] KLA1.020 0.980 1.030 0.970 1.020 1.050 1.050
Compactin1.090 1.000 0.990 0.960 1.080 1.080 1.010
KLA/Compactin1.020 1.080 1.010 0.960 1.010 0.990 1.040
Ace
KLA  Compactin  Compactin+KLA
 NM_009598 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (Ace), transcript variant 2, mRNA [NM_009598] KLA1.110 1.060 1.070 1.030 1.040 0.980 1.010
Compactin0.930 0.950 0.980 1.000 1.080 1.090 1.000
KLA/Compactin1.020 1.120 1.040 1.020 1.110 1.030 0.970
Ace2
KLA  Compactin  Compactin+KLA
 194473665 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 KLA1.050 1.010 1.000 1.070 1.010 1.030 1.020
Compactin0.980 1.030 0.960 0.980 0.980 0.950 0.970
KLA/Compactin0.990 0.970 1.000 1.000 0.990 1.010 1.010
Ace2
KLA  Compactin  Compactin+KLA
 NM_027286 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), mRNA [NM_027286] KLA1.000 1.000 0.980 0.970 1.010 1.000 1.020
Compactin1.020 1.090 1.000 1.000 1.010 1.030 0.990
KLA/Compactin0.970 1.000 1.030 0.930 1.010 1.010 1.020
Ace3
KLA  Compactin  Compactin+KLA
 82935400 angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 KLA1.020 0.960 0.980 1.040 0.990 0.920 0.980
Compactin0.890 0.900 1.010 0.970 1.070 1.050 0.890
KLA/Compactin0.940 1.010 1.040 1.000 1.160 0.980 1.080
Ace3
KLA  Compactin  Compactin+KLA
 NM_001101453 angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 (Ace3), mRNA [NM_001101453] KLA0.960 0.970 1.070 0.950 1.050 1.120 1.020
Compactin0.900 0.940 1.060 1.000 0.940 1.040 1.050
KLA/Compactin0.990 1.040 1.010 1.020 1.010 0.950 1.030
Agt
KLA  Compactin  Compactin+KLA
 NM_007428 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (Agt), mRNA [NM_007428] KLA1.010 0.970 1.030 0.980 1.060 0.970 0.930
Compactin1.020 1.050 0.940 1.050 0.990 1.000 0.920
KLA/Compactin0.980 0.980 1.000 0.970 0.940 0.900 0.960
Agtr1a
KLA  Compactin  Compactin+KLA
 NM_177322 angiotensin II receptor, type 1a (Agtr1a), mRNA [NM_177322] KLA1.000 1.050 1.000 1.070 1.030 0.970 0.980
Compactin1.050 1.040 1.030 1.070 1.010 0.940 1.030
KLA/Compactin0.990 1.050 0.970 0.970 1.000 1.050 1.080
Agtr1a
KLA  Compactin  Compactin+KLA
 NM_177322 angiotensin II receptor, type 1a (Agtr1a), mRNA [NM_177322] KLA1.060 0.940 0.920 0.940 0.900 1.000 0.990
Compactin0.910 1.010 0.980 0.920 0.920 0.970 0.920
KLA/Compactin0.910 0.970 1.020 0.980 0.980 0.910 1.050
Agtr1b
KLA  Compactin  Compactin+KLA
 NM_175086 angiotensin II receptor, type 1b (Agtr1b), mRNA [NM_175086] KLA1.010 1.010 0.990 0.960 1.060 1.000 0.960
Compactin0.990 1.090 1.040 1.010 0.990 0.970 1.020
KLA/Compactin0.990 1.010 1.000 1.030 0.960 1.060 1.020
Agtr2
KLA  Compactin  Compactin+KLA
 NM_007429 angiotensin II receptor, type 2 (Agtr2), mRNA [NM_007429] KLA0.930 1.020 0.990 1.010 1.010 1.000 1.000
Compactin1.070 1.000 0.970 1.020 1.100 1.020 0.810
KLA/Compactin0.980 0.980 0.970 1.040 1.010 1.020 0.960
Anpep
KLA  Compactin  Compactin+KLA
 NM_008486 alanyl (membrane) aminopeptidase (Anpep), mRNA [NM_008486] KLA1.150 1.020 1.150 0.910 1.490 1.580 0.860
Compactin1.030 1.240 1.190 1.060 0.670 0.610 0.580
KLA/Compactin1.200 1.030 0.970 1.110 1.250 1.510 0.820
Cma1
KLA  Compactin  Compactin+KLA
 NM_010780 chymase 1, mast cell (Cma1), mRNA [NM_010780] KLA1.030 1.010 1.030 0.950 0.930 0.950 0.980
Compactin0.930 0.990 0.840 0.950 1.010 0.980 1.320
KLA/Compactin0.980 1.040 0.990 0.920 1.050 0.950 1.010
Cma1
KLA  Compactin  Compactin+KLA
 NM_010780 chymase 1, mast cell (Cma1), mRNA [NM_010780] KLA1.040 1.020 1.030 1.040 0.970 0.960 0.990
Compactin0.990 0.960 0.940 1.020 1.080 1.010 1.030
KLA/Compactin1.070 1.000 1.030 1.010 1.000 1.000 1.050
Cpa3
KLA  Compactin  Compactin+KLA
 NM_007753 carboxypeptidase A3, mast cell (Cpa3), mRNA [NM_007753] KLA1.030 0.970 0.960 1.000 1.090 1.030 1.010
Compactin1.050 1.110 0.930 1.020 1.050 0.980 0.990
KLA/Compactin1.030 1.000 0.950 0.990 0.970 1.140 0.980
Ctsa
KLA  Compactin  Compactin+KLA
 NM_008906 cathepsin A (Ctsa), transcript variant 1, mRNA [NM_008906] KLA1.010 0.850 0.720 0.680 0.850 0.710 0.570
Compactin1.100 1.040 1.030 1.000 0.950 0.800 0.750
KLA/Compactin1.100 0.810 0.740 0.730 0.730 0.620 0.500
Ctsa
KLA  Compactin  Compactin+KLA
 NM_008906 cathepsin A (Ctsa), transcript variant 1, mRNA [NM_008906] KLA1.020 0.890 0.860 0.730 0.960 0.920 0.940
Compactin0.900 0.940 1.060 0.860 0.930 0.860 0.870
KLA/Compactin1.060 0.930 0.980 0.720 0.760 0.840 0.890
Ctsa
KLA  Compactin  Compactin+KLA
 NM_008906 cathepsin A (Ctsa), transcript variant 1, mRNA [NM_008906] KLA1.100 0.960 1.060 0.890 0.870 0.970 0.960
Compactin0.940 1.020 0.990 0.940 0.950 0.920 0.860
KLA/Compactin1.040 1.000 0.910 0.780 0.740 0.910 0.920
Ctsg
KLA  Compactin  Compactin+KLA
 NM_007800 cathepsin G (Ctsg), mRNA [NM_007800] KLA1.110 1.000 1.010 1.060 0.970 1.000 0.890
Compactin0.980 1.020 0.960 0.990 1.060 1.090 1.000
KLA/Compactin0.970 1.020 1.000 0.970 1.030 0.920 0.910
Enpep
KLA  Compactin  Compactin+KLA
 NM_007934 glutamyl aminopeptidase (Enpep), mRNA [NM_007934] KLA1.020 1.060 0.990 0.910 1.000 1.030 1.160
Compactin0.960 1.040 1.020 1.000 0.930 0.980 1.040
KLA/Compactin1.020 0.930 0.980 1.060 0.980 0.910 1.010
Lnpep
KLA  Compactin  Compactin+KLA
 AK147232 cDNA, RIKEN full-length enriched library, clone:M5C1000C02 product:hypothetical protein, full insert sequence [AK147232] KLA1.060 0.970 1.260 1.360 1.730 1.690 1.120
Compactin0.860 0.970 0.950 1.000 1.020 1.060 1.250
KLA/Compactin0.950 1.010 1.020 1.400 1.690 1.890 1.280
Lnpep
KLA  Compactin  Compactin+KLA
 NM_172827 leucyl/cystinyl aminopeptidase (Lnpep), mRNA [NM_172827] KLA0.840 1.260 1.210 2.120 3.630 2.640 4.380
Compactin0.840 0.910 0.920 0.800 1.220 1.300 1.620
KLA/Compactin0.970 1.270 1.430 2.320 2.910 4.510 7.820
Lnpep
KLA  Compactin  Compactin+KLA
 NM_172827 leucyl/cystinyl aminopeptidase (Lnpep), mRNA [NM_172827] KLA1.190 1.330 1.650 2.260 3.150 3.300 4.200
Compactin0.960 1.070 1.250 1.010 1.050 1.250 1.450
KLA/Compactin1.080 1.260 1.650 2.630 3.400 4.820 5.890
Mas1
KLA  Compactin  Compactin+KLA
 NM_008552 MAS1 oncogene (Mas1), mRNA [NM_008552] KLA0.990 1.010 0.970 0.860 0.930 1.070 0.900
Compactin0.980 1.010 0.980 0.980 0.950 0.970 0.930
KLA/Compactin0.960 0.940 0.990 1.060 1.030 0.920 0.910
Mas1
KLA  Compactin  Compactin+KLA
 NM_008552 MAS1 oncogene (Mas1), mRNA [NM_008552] KLA1.010 1.060 0.980 1.020 0.970 0.940 1.000
Compactin0.980 1.020 1.000 0.990 1.040 0.930 0.940
KLA/Compactin0.980 1.040 0.890 0.980 1.040 0.990 0.960
Mme
KLA  Compactin  Compactin+KLA
 NM_008604 membrane metallo endopeptidase (Mme), mRNA [NM_008604] KLA1.010 1.000 0.950 1.010 1.060 0.640 1.000
Compactin1.020 0.960 1.100 0.990 1.050 1.000 0.970
KLA/Compactin1.030 1.000 1.030 0.980 0.980 0.970 0.970
Mme
KLA  Compactin  Compactin+KLA
 NM_008604 membrane metallo endopeptidase (Mme), mRNA [NM_008604] KLA1.050 1.030 0.990 1.040 1.080 0.960 1.000
Compactin1.010 1.060 1.010 1.050 1.060 1.030 1.010
KLA/Compactin1.040 1.000 0.990 0.960 1.060 1.000 1.050
Nln
KLA  Compactin  Compactin+KLA
 NM_029447 neurolysin (metallopeptidase M3 family) (Nln), mRNA [NM_029447] KLA0.920 0.980 0.940 0.910 0.960 0.860 0.710
Compactin0.920 0.940 0.970 1.000 0.880 0.990 0.960
KLA/Compactin0.980 0.940 0.960 0.830 0.950 0.880 0.780
Nln
KLA  Compactin  Compactin+KLA
 NM_029447 neurolysin (metallopeptidase M3 family) (Nln), mRNA [NM_029447] KLA1.000 0.970 0.970 0.920 1.450 1.550 1.370
Compactin0.950 1.030 0.900 1.040 1.010 1.080 1.120
KLA/Compactin1.020 1.070 0.900 0.880 1.450 1.890 1.590
Ren1
KLA  Compactin  Compactin+KLA
 149234179 renin 1 structural KLA1.050 0.980 1.000 0.980 1.030 0.930 0.900
Compactin1.060 0.950 1.030 1.110 1.220 1.200 1.060
KLA/Compactin1.010 1.000 0.970 0.980 1.180 1.290 0.930
Ren1
KLA  Compactin  Compactin+KLA
 NM_031192 renin 1 structural (Ren1), mRNA [NM_031192] KLA1.000 0.980 1.000 0.940 0.960 0.940 0.940
Compactin0.970 0.970 0.920 0.980 0.960 1.020 0.930
KLA/Compactin1.020 1.020 1.030 0.960 1.020 0.910 0.900
Ren1
KLA  Compactin  Compactin+KLA
 NM_031192 renin 1 structural (Ren1), mRNA [NM_031192] KLA1.020 0.930 1.010 0.990 0.970 0.970 1.040
Compactin1.040 1.020 1.060 0.980 1.020 1.020 0.970
KLA/Compactin1.010 1.010 1.030 0.960 1.020 1.070 0.990
Ren1
KLA  Compactin  Compactin+KLA
 NM_031192 renin 1 structural (Ren1), mRNA [NM_031192] KLA1.080 0.930 0.910 0.970 0.980 1.080 0.980
Compactin0.960 1.040 1.040 0.970 1.000 1.070 0.960
KLA/Compactin0.940 0.980 1.010 1.020 0.970 1.030 1.040
Ren2
KLA  Compactin  Compactin+KLA
 NM_031193 renin 2 tandem duplication of Ren1 (Ren2), mRNA [NM_031193] KLA1.070 0.950 0.990 1.050 0.940 0.940 0.990
Compactin1.070 1.050 0.940 1.000 1.010 1.010 0.900
KLA/Compactin0.970 0.990 0.990 0.970 0.960 1.000 0.930
Thop1
KLA  Compactin  Compactin+KLA
 141801686 thimet oligopeptidase 1 KLA0.980 1.050 0.930 1.000 0.890 0.910 0.970
Compactin1.020 1.000 1.000 0.930 1.010 1.030 0.950
KLA/Compactin0.960 1.050 1.040 0.980 0.950 1.000 0.970
Thop1
KLA  Compactin  Compactin+KLA
 NM_022653 thimet oligopeptidase 1 (Thop1), mRNA [NM_022653] KLA0.980 1.000 1.130 1.120 0.850 0.950 1.270
Compactin1.170 0.980 1.090 1.140 0.950 0.990 0.850
KLA/Compactin1.040 1.070 1.130 1.060 0.820 0.770 1.070