Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: 2-Oxocarboxylic acid metabolism (mmu01210)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
4933405O
20Rik
KLA  Compactin  Compactin+KLA
 NM_172901 RIKEN cDNA 4933405O20 gene (4933405O20Rik), mRNA [NM_172901] KLA1.000 1.000 0.990 0.940 0.970 0.930 0.970
Compactin1.090 0.950 0.980 1.000 1.030 1.010 1.010
KLA/Compactin0.980 1.040 1.040 1.000 0.990 1.010 1.010
Aadat
KLA  Compactin  Compactin+KLA
 NM_011834 aminoadipate aminotransferase (Aadat), mRNA [NM_011834] KLA1.040 1.030 1.000 0.990 0.950 1.060 0.960
Compactin1.020 0.940 1.000 1.000 0.990 0.970 1.020
KLA/Compactin1.020 0.940 0.970 0.980 0.970 1.010 0.990
Aco1
KLA  Compactin  Compactin+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA1.020 0.960 1.010 1.000 0.920 0.940 0.970
Compactin1.070 1.100 1.040 1.020 1.040 0.960 0.930
KLA/Compactin1.060 1.040 0.980 0.970 0.890 0.870 0.900
Aco1
KLA  Compactin  Compactin+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA1.140 1.090 0.940 0.850 0.880 1.040 0.960
Compactin1.270 1.190 1.140 1.140 1.260 1.060 1.020
KLA/Compactin1.130 1.100 1.060 0.910 1.060 0.980 0.940
Aco2
KLA  Compactin  Compactin+KLA
 AK029122 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122] KLA0.940 1.040 1.020 0.970 1.010 1.040 0.980
Compactin0.990 0.990 1.000 1.020 0.980 0.990 0.910
KLA/Compactin0.940 1.030 0.960 0.970 0.960 0.960 1.060
Aco2
KLA  Compactin  Compactin+KLA
 NM_080633 aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633] KLA1.610 1.480 1.170 1.030 0.860 0.980 1.110
Compactin1.000 1.330 1.540 1.170 1.090 0.880 0.930
KLA/Compactin1.370 1.130 1.320 1.180 0.970 0.960 0.750
Acy1
KLA  Compactin  Compactin+KLA
 NM_025371 aminoacylase 1 (Acy1), mRNA [NM_025371] KLA0.940 1.050 1.170 1.130 1.130 1.270 1.380
Compactin0.970 1.020 1.110 1.030 1.010 1.070 0.930
KLA/Compactin1.010 1.060 1.130 1.170 1.070 1.110 1.120
Bcat1
KLA  Compactin  Compactin+KLA
 NM_001024468 branched chain aminotransferase 1, cytosolic (Bcat1), transcript variant 1, mRNA [NM_001024468] KLA0.940 0.970 1.050 1.110 1.300 1.350 1.170
Compactin1.000 1.030 1.040 1.130 1.040 1.010 0.990
KLA/Compactin0.980 1.090 1.300 1.320 1.440 1.190 1.100
Bcat1
KLA  Compactin  Compactin+KLA
 NM_001024468 branched chain aminotransferase 1, cytosolic (Bcat1), transcript variant 1, mRNA [NM_001024468] KLA1.030 1.060 1.080 1.300 1.770 1.550 1.210
Compactin1.000 1.080 1.130 1.180 1.030 0.970 1.440
KLA/Compactin1.040 1.070 1.100 1.630 1.600 1.160 1.000
Bcat2
KLA  Compactin  Compactin+KLA
 NM_009737 branched chain aminotransferase 2, mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA [NM_009737] KLA0.780 1.010 1.170 1.070 0.900 1.000 1.090
Compactin1.020 1.090 1.110 1.080 1.050 1.370 0.980
KLA/Compactin1.010 0.990 1.050 1.020 0.960 1.080 1.130
Bcat2
KLA  Compactin  Compactin+KLA
 NM_009737 branched chain aminotransferase 2, mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA [NM_009737] KLA0.860 1.010 1.000 1.020 0.950 0.970 1.050
Compactin1.030 1.040 0.960 1.130 1.120 1.240 0.990
KLA/Compactin0.960 1.040 0.880 0.980 1.000 1.050 1.130
Bcat2
KLA  Compactin  Compactin+KLA
 NM_009737 branched chain aminotransferase 2, mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA [NM_009737] KLA1.020 2.730 1.000 1.010 0.990 0.950 1.010
Compactin1.050 0.960 0.960 0.990 0.950 0.950 0.990
KLA/Compactin1.030 1.000 1.030 1.000 0.970 0.920 0.980
Cs
KLA  Compactin  Compactin+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA1.010 0.960 1.060 0.940 0.790 0.970 0.950
Compactin1.060 0.950 1.120 1.190 1.000 1.090 1.080
KLA/Compactin1.160 1.020 1.020 1.010 0.920 0.860 0.720
Cs
KLA  Compactin  Compactin+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA1.170 1.140 1.160 1.090 1.070 1.280 1.460
Compactin1.180 1.140 1.120 1.250 1.080 1.020 1.120
KLA/Compactin1.230 1.070 1.140 1.260 1.130 1.090 1.660
Csl
KLA  Compactin  Compactin+KLA
 NM_027945 citrate synthase like (Csl), mRNA [NM_027945] KLA0.880 0.970 0.880 1.070 1.080 0.940 1.590
Compactin0.960 0.880 0.780 0.790 1.120 1.050 0.880
KLA/Compactin0.970 1.020 0.920 0.910 0.960 1.440 1.770
Got1
KLA  Compactin  Compactin+KLA
 NM_010324 glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324] KLA0.990 0.960 0.820 0.740 0.780 1.140 1.350
Compactin1.110 1.060 1.070 1.250 0.950 0.700 0.640
KLA/Compactin1.020 1.050 0.850 0.770 0.760 1.070 1.070
Got2
KLA  Compactin  Compactin+KLA
 NM_010325 glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325] KLA0.960 1.030 1.060 0.940 0.870 0.810 1.090
Compactin1.130 1.000 1.060 1.010 1.080 0.990 0.880
KLA/Compactin1.100 1.000 1.120 1.040 0.870 0.940 0.940
Gpt
KLA  Compactin  Compactin+KLA
 NM_182805 glutamic pyruvic transaminase, soluble (Gpt), mRNA [NM_182805] KLA1.040 1.100 0.980 0.910 0.850 0.840 0.910
Compactin0.980 1.000 1.070 1.040 0.930 1.000 0.880
KLA/Compactin1.000 1.010 0.950 0.950 0.800 0.800 0.920
Gpt2
KLA  Compactin  Compactin+KLA
 NM_173866 glutamic pyruvate transaminase (alanine aminotransferase) 2 (Gpt2), mRNA [NM_173866] KLA0.950 1.040 1.020 0.860 1.120 1.460 1.030
Compactin0.970 1.010 1.140 1.140 1.100 1.040 1.540
KLA/Compactin1.010 0.980 0.900 1.010 1.380 1.730 0.920
Idh1
KLA  Compactin  Compactin+KLA
 NM_010497 isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant 2, mRNA [NM_010497] KLA0.990 0.560 0.780 0.700 0.500 0.530 0.470
Compactin0.920 0.990 0.790 0.800 1.010 1.280 0.980
KLA/Compactin0.840 0.830 0.710 0.590 0.530 0.600 0.450
Idh2
KLA  Compactin  Compactin+KLA
 NM_173011 isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein, mRNA [NM_173011] KLA0.870 0.920 0.850 0.810 0.680 0.530 0.570
Compactin0.980 0.910 0.840 0.830 1.060 0.950 0.690
KLA/Compactin0.950 1.000 0.800 0.710 0.660 0.470 0.660
Idh3a
KLA  Compactin  Compactin+KLA
 NM_029573 isocitrate dehydrogenase 3 (NAD+) alpha (Idh3a), nuclear gene encoding mitochondrial protein, mRNA [NM_029573] KLA1.220 1.180 1.190 0.950 0.720 0.660 0.820
Compactin1.170 1.090 1.100 1.140 1.150 0.980 0.870
KLA/Compactin1.180 1.030 1.050 1.050 0.760 0.640 0.700
Idh3b
KLA  Compactin  Compactin+KLA
 NM_130884 isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884] KLA1.030 1.070 1.120 0.960 0.980 1.010 1.130
Compactin1.000 1.000 1.160 1.060 0.990 1.120 0.960
KLA/Compactin1.180 0.980 1.200 1.060 0.970 0.900 1.180
Idh3b
KLA  Compactin  Compactin+KLA
 NM_130884 isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884] KLA1.210 1.160 1.200 1.080 1.150 1.060 0.930
Compactin1.060 1.080 1.190 1.000 1.130 0.890 0.800
KLA/Compactin1.130 0.940 1.260 1.130 1.070 0.970 1.140
Idh3g
KLA  Compactin  Compactin+KLA
 NM_008323 isocitrate dehydrogenase 3 (NAD+), gamma (Idh3g), nuclear gene encoding mitochondrial protein, mRNA [NM_008323] KLA1.160 1.050 1.080 0.970 0.890 0.640 0.480
Compactin0.930 1.230 1.370 1.000 1.050 0.920 0.840
KLA/Compactin0.900 0.920 1.370 0.980 0.810 0.570 0.560
Nags
KLA  Compactin  Compactin+KLA
 NM_145829 N-acetylglutamate synthase (Nags), transcript variant 1, mRNA [NM_145829] KLA0.960 1.040 1.070 0.960 1.020 0.940 1.070
Compactin1.040 1.030 1.020 0.960 1.080 1.030 1.000
KLA/Compactin0.960 1.040 1.000 0.970 0.980 1.060 1.060
Nags
KLA  Compactin  Compactin+KLA
 NM_178053 N-acetylglutamate synthase (Nags), transcript variant 2, mRNA [NM_178053] KLA1.080 1.010 1.010 1.020 1.010 1.020 0.960
Compactin1.010 1.060 0.990 0.990 1.040 1.070 1.030
KLA/Compactin1.000 0.900 0.950 0.990 1.010 1.000 1.030