Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Introduction | Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Folate biosynthesis (mmu00790)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
Akp3	KLA Compactin Compactin+KLA	NM_007432	alkaline phosphatase 3, intestine, not Mn requiring (Akp3), mRNA [NM_007432]	KLA	1.010	1.010	0.980	0.960	1.000	1.060	1.010
				Compactin	0.980	0.990	1.020	0.960	1.010	1.040	1.010
				KLA/Compactin	0.970	0.970	0.970	1.000	1.010	0.910	1.090

Akp5	KLA Compactin Compactin+KLA	NM_007433		alkaline phosphatase 5 (Akp5), mRNA [NM_007433]	KLA	0.990	1.010	1.030	1.040	0.970	0.940	0.980
					Compactin	0.950	0.950	1.050	0.920	0.930	0.980	0.980
					KLA/Compactin	0.990	1.040	1.020	0.980	0.990	1.000	1.020

Alpi	KLA Compactin Compactin+KLA	124487322	alkaline phosphatase, intestinal	KLA	1.060	0.970	0.990	1.030	0.980	0.950	1.050
				Compactin	1.010	0.960	1.030	0.970	0.980	1.030	0.980
				KLA/Compactin	0.980	1.050	1.000	0.960	1.000	1.010	1.040

Alpi	KLA Compactin Compactin+KLA	NM_001081082		alkaline phosphatase, intestinal (Alpi), mRNA [NM_001081082]	KLA	0.920	0.990	1.020	0.960	1.010	1.040	1.160
					Compactin	0.900	0.950	1.050	1.040	1.040	1.050	1.100
					KLA/Compactin	1.020	0.970	0.990	1.000	1.100	1.100	0.990

Alpi	KLA Compactin Compactin+KLA	NM_001081082	alkaline phosphatase, intestinal (Alpi), mRNA [NM_001081082]	KLA	1.030	1.040	1.000	0.990	1.050	0.840	1.060
				Compactin	0.960	0.980	1.020	0.960	1.040	0.950	0.970
				KLA/Compactin	0.990	1.010	0.990	1.000	0.950	0.960	0.970

Alpl	KLA Compactin Compactin+KLA	NM_007431		alkaline phosphatase, liver/bone/kidney (Alpl), mRNA [NM_007431]	KLA	1.030	1.040	1.020	0.930	0.990	1.100	1.010
					Compactin	0.970	1.000	1.030	1.010	0.960	1.030	1.050
					KLA/Compactin	1.020	0.960	1.020	1.020	0.900	0.960	1.020

Dhfr	KLA Compactin Compactin+KLA	L26316	dihydrofolate reductase (dhfr) mRNA, complete cds. [L26316]	KLA	1.100	1.100	0.980	0.830	0.560	0.630	0.740
				Compactin	1.060	1.060	1.060	1.180	0.920	1.000	0.820
				KLA/Compactin	1.060	1.040	1.020	0.750	0.490	0.390	0.580

Dhfr	KLA Compactin Compactin+KLA	NM_010049		dihydrofolate reductase (Dhfr), mRNA [NM_010049]	KLA	0.940	0.990	0.860	0.700	0.460	0.450	0.650
					Compactin	0.960	0.970	0.900	0.960	0.890	0.810	0.740
					KLA/Compactin	0.840	0.930	0.760	0.610	0.370	0.350	0.530

Dhfr	KLA Compactin Compactin+KLA	NM_010049	dihydrofolate reductase (Dhfr), mRNA [NM_010049]	KLA	1.410	1.200	0.930	0.610	0.590	0.570	0.650
				Compactin	1.350	1.280	1.140	1.300	0.890	0.820	0.770
				KLA/Compactin	1.310	1.080	0.870	0.560	0.490	0.440	0.570

Fpgs	KLA Compactin Compactin+KLA	NM_010236		folylpolyglutamyl synthetase (Fpgs), nuclear gene encoding mitochondrial protein, mRNA [NM_010236]	KLA	0.910	0.950	0.840	0.760	0.790	0.910	0.630
					Compactin	1.060	0.860	1.170	1.130	1.070	1.130	1.070
					KLA/Compactin	1.000	0.970	0.880	0.730	1.060	0.400	0.460

Gch1	KLA Compactin Compactin+KLA	NM_008102	GTP cyclohydrolase 1 (Gch1), mRNA [NM_008102]	KLA	0.800	1.070	1.350	2.950	1.680	1.190	1.230
				Compactin	0.820	0.850	0.900	0.990	0.940	0.930	1.290
				KLA/Compactin	0.830	1.020	1.100	2.830	1.650	1.560	1.050

Gch1	KLA Compactin Compactin+KLA	NM_008102		GTP cyclohydrolase 1 (Gch1), mRNA [NM_008102]	KLA	0.910	1.410	1.800	4.430	5.540	4.490	6.180
					Compactin	1.010	0.910	0.910	1.130	1.040	1.150	1.520
					KLA/Compactin	0.930	1.230	1.660	3.940	6.510	7.100	5.160

Ggh	KLA Compactin Compactin+KLA	NM_010281	gamma-glutamyl hydrolase (Ggh), mRNA [NM_010281]	KLA	0.790	0.940	0.780	1.000	1.320	1.300	2.710
				Compactin	0.810	0.850	0.760	0.740	1.060	1.260	1.580
				KLA/Compactin	0.690	0.860	0.860	1.030	1.070	1.490	3.200

Ggh	KLA Compactin Compactin+KLA	NM_010281		gamma-glutamyl hydrolase (Ggh), mRNA [NM_010281]	KLA	0.910	1.040	0.890	1.160	1.170	1.210	2.310
					Compactin	0.840	0.910	0.870	0.810	0.980	1.220	1.270
					KLA/Compactin	0.810	0.990	0.900	1.090	1.190	1.540	3.440

Mocs1	KLA Compactin Compactin+KLA	NM_020042	molybdenum cofactor synthesis 1 (Mocs1), transcript variant 1, mRNA [NM_020042]	KLA	0.840	0.970	0.920	1.140	1.380	1.610	1.720
				Compactin	0.860	0.880	0.880	0.980	1.050	1.090	1.170
				KLA/Compactin	0.900	1.010	0.830	1.190	1.900	2.050	1.770

Mocs1	KLA Compactin Compactin+KLA	NM_020042		molybdenum cofactor synthesis 1 (Mocs1), transcript variant 1, mRNA [NM_020042]	KLA	1.010	1.010	1.010	1.000	0.970	1.020	1.080
					Compactin	0.920	1.010	0.980	0.930	1.020	0.990	0.990
					KLA/Compactin	0.940	0.960	0.970	0.950	1.060	0.990	0.990

Mocs1	KLA Compactin Compactin+KLA	NM_020042	molybdenum cofactor synthesis 1 (Mocs1), transcript variant 1, mRNA [NM_020042]	KLA	1.010	1.120	1.020	1.120	1.120	1.070	1.230
				Compactin	0.970	1.010	0.900	0.920	1.070	1.120	1.080
				KLA/Compactin	0.970	1.190	0.990	1.180	1.120	1.400	1.550

Mocs2	KLA Compactin Compactin+KLA	AF091872		molybdopterin-synthase small and large subunit (Mocs2) bicistronic mRNA, complete cds. [AF091872]	KLA	0.870	0.830	0.840	1.130	1.510	2.630	3.870
					Compactin	0.910	0.920	0.930	1.050	0.930	0.920	1.220
					KLA/Compactin	0.740	0.890	0.830	1.060	1.940	2.600	3.690

Mocs2	KLA Compactin Compactin+KLA	NM_013826	molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA [NM_013826]	KLA	0.910	0.910	0.940	1.110	1.560	2.670	3.540
				Compactin	0.930	0.970	0.950	0.970	0.950	1.010	1.190
				KLA/Compactin	0.880	0.830	0.870	1.110	1.980	2.670	3.830

Mocs2	KLA Compactin Compactin+KLA	NM_013826		molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA [NM_013826]	KLA	1.060	0.930	1.060	1.330	1.990	2.540	3.390
					Compactin	1.140	1.120	1.250	1.220	1.150	0.950	1.120
					KLA/Compactin	0.990	0.850	1.080	1.400	2.280	2.270	3.890

Pts	KLA Compactin Compactin+KLA	NM_011220	6-pyruvoyl-tetrahydropterin synthase (Pts), mRNA [NM_011220]	KLA	0.950	0.970	0.950	0.990	0.680	0.710	0.670
				Compactin	1.000	1.040	1.070	1.150	1.110	0.930	0.960
				KLA/Compactin	0.860	0.940	0.890	0.990	0.760	0.690	0.650

Pts	KLA Compactin Compactin+KLA	NM_011220		6-pyruvoyl-tetrahydropterin synthase (Pts), mRNA [NM_011220]	KLA	1.050	0.970	1.050	1.120	0.700	0.730	0.740
					Compactin	1.160	1.100	1.100	1.420	1.210	0.980	0.810
					KLA/Compactin	1.140	0.980	1.050	1.020	0.930	0.720	0.680

Qdpr	KLA Compactin Compactin+KLA	NM_024236	quinoid dihydropteridine reductase (Qdpr), mRNA [NM_024236]	KLA	1.030	0.940	0.690	0.900	0.880	0.710	0.740
				Compactin	0.900	0.830	0.860	0.790	0.970	1.200	0.840
				KLA/Compactin	0.880	1.060	1.080	0.860	0.660	0.540	1.020

Spr	KLA Compactin Compactin+KLA	NM_011467		sepiapterin reductase (Spr), mRNA [NM_011467]	KLA	1.240	1.080	1.040	0.980	0.750	0.860	0.830
					Compactin	1.260	1.250	1.040	1.240	1.120	0.900	1.080
					KLA/Compactin	1.130	1.060	1.080	0.990	0.850	0.720	0.720

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Folate biosynthesis (mmu00790)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios