Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Butanoate metabolism (mmu00650)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
Aacs	KLA Compactin Compactin+KLA	NM_030210	acetoacetyl-CoA synthetase (Aacs), mRNA [NM_030210]	KLA	1.050	0.950	0.990	0.670	0.970	0.880	0.940
				Compactin	1.210	1.090	1.160	1.400	1.310	1.120	1.000
				KLA/Compactin	1.210	0.910	1.120	0.820	1.010	0.850	0.680

Abat	KLA Compactin Compactin+KLA	AK083062		12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062]	KLA	1.000	0.960	1.000	1.000	1.050	0.950	1.020
					Compactin	1.070	1.010	1.010	1.000	1.010	1.010	0.980
					KLA/Compactin	1.010	1.020	1.030	1.010	1.020	0.990	1.070

Abat	KLA Compactin Compactin+KLA	NM_172961	4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961]	KLA	0.980	1.020	1.000	0.950	1.010	0.960	1.030
				Compactin	0.990	1.020	0.950	1.060	1.030	1.020	0.990
				KLA/Compactin	1.020	0.980	0.990	0.950	1.000	0.990	0.990

Acads	KLA Compactin Compactin+KLA	NM_007383		acyl-Coenzyme A dehydrogenase, short chain (Acads), nuclear gene encoding mitochondrial protein, mRNA [NM_007383]	KLA	1.040	1.040	1.010	0.930	0.830	0.920	1.230
					Compactin	1.080	1.080	1.160	1.260	1.090	1.150	1.080
					KLA/Compactin	1.010	1.020	1.020	0.880	0.860	1.220	1.290

Acat1	KLA Compactin Compactin+KLA	118130035	acetyl-Coenzyme A acetyltransferase 1	KLA	0.990	1.040	0.990	0.950	1.030	0.910	0.970
				Compactin	1.040	1.040	0.960	0.990	1.100	0.980	1.050
				KLA/Compactin	1.010	1.040	0.960	0.950	0.980	1.040	0.970

Acat1	KLA Compactin Compactin+KLA	NM_144784		acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784]	KLA	1.060	1.000	1.140	1.120	0.890	0.890	0.650
					Compactin	1.130	1.130	1.170	1.190	0.980	1.080	1.040
					KLA/Compactin	1.210	1.040	1.190	1.100	0.950	0.850	0.700

Acat2	KLA Compactin Compactin+KLA	NM_009338	acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338]	KLA	0.990	0.960	0.940	1.000	0.740	0.880	0.980
				Compactin	0.990	1.060	1.190	1.150	1.100	1.090	0.920
				KLA/Compactin	0.940	1.030	1.020	1.020	0.870	0.880	0.960

Acsm1	KLA Compactin Compactin+KLA	NM_054094		acyl-CoA synthetase medium-chain family member 1 (Acsm1), mRNA [NM_054094]	KLA	0.990	1.020	0.980	1.020	0.920	0.970	1.000
					Compactin	1.040	1.040	1.010	0.970	1.050	1.000	0.960
					KLA/Compactin	0.970	1.000	1.040	1.000	1.060	1.090	1.010

Acsm1	KLA Compactin Compactin+KLA	NM_054094	acyl-CoA synthetase medium-chain family member 1 (Acsm1), mRNA [NM_054094]	KLA	1.030	0.930	0.910	0.960	1.000	1.050	0.960
				Compactin	1.010	1.000	0.980	1.080	1.050	1.020	0.980
				KLA/Compactin	0.930	0.940	1.030	1.030	1.000	1.010	0.990

Acsm2	KLA Compactin Compactin+KLA	AK165449		adult male kidney cDNA, RIKEN full-length enriched library, clone:F530004J10 product:unclassifiable, full insert sequence [AK165449]	KLA	0.990	1.040	1.040	0.990	0.970	1.050	0.980
					Compactin	0.910	0.990	0.930	0.940	0.940	0.940	1.100
					KLA/Compactin	0.970	0.890	0.970	1.060	0.950	0.980	1.040

Acsm2	KLA Compactin Compactin+KLA	AK165449	adult male kidney cDNA, RIKEN full-length enriched library, clone:F530004J10 product:unclassifiable, full insert sequence [AK165449]	KLA	1.010	0.980	1.000	1.010	0.940	0.990	0.950
				Compactin	0.930	1.020	1.010	0.970	0.930	0.990	1.000
				KLA/Compactin	0.970	1.020	1.020	1.040	1.040	0.980	1.030

Acsm2	KLA Compactin Compactin+KLA	NM_146197		acyl-CoA synthetase medium-chain family member 2 (Acsm2), mRNA [NM_146197]	KLA	0.950	0.990	0.990	0.940	0.990	1.060	1.000
					Compactin	0.940	0.930	0.830	1.070	1.000	0.960	1.050
					KLA/Compactin	1.040	1.010	0.960	1.070	0.970	1.050	1.060

Acsm2	KLA Compactin Compactin+KLA	NM_146197	acyl-CoA synthetase medium-chain family member 2 (Acsm2), mRNA [NM_146197]	KLA	0.990	0.970	1.070	1.050	0.890	0.980	1.000
				Compactin	1.010	0.960	0.990	1.090	1.030	1.000	0.990
				KLA/Compactin	1.010	0.990	0.880	1.010	1.050	1.030	1.020

Acsm3	KLA Compactin Compactin+KLA	NM_212441		acyl-CoA synthetase medium-chain family member 3 (Acsm3), transcript variant 2, mRNA [NM_212441]	KLA	1.030	0.930	0.930	0.980	0.970	0.910	0.950
					Compactin	0.980	1.010	0.990	1.030	1.110	1.010	0.970
					KLA/Compactin	0.970	1.040	1.030	0.970	0.970	1.010	0.970

Acsm4	KLA Compactin Compactin+KLA	NM_178414	acyl-CoA synthetase medium-chain family member 4 (Acsm4), mRNA [NM_178414]	KLA	0.990	1.000	0.960	0.910	1.010	0.980	0.950
				Compactin	1.000	1.070	0.990	1.000	1.030	0.980	0.990
				KLA/Compactin	1.020	1.030	0.990	0.990	1.030	0.970	1.070

Acsm5	KLA Compactin Compactin+KLA	NM_178758		acyl-CoA synthetase medium-chain family member 5 (Acsm5), mRNA [NM_178758]	KLA	0.940	1.000	0.950	0.900	0.980	1.090	1.010
					Compactin	0.950	0.960	1.060	0.990	1.020	1.010	1.010
					KLA/Compactin	0.950	0.910	0.940	0.990	1.000	0.910	0.990

Aldh5a1	KLA Compactin Compactin+KLA	AK051603	12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130059J11 product:succinate-semialdehyde dehydrogenase (EC 1.2.1.24) (fragment) homolog [Rattus norvegicus], full insert sequence. [AK051603]	KLA	1.050	1.000	1.050	1.000	1.070	1.070	1.040
				Compactin	1.040	0.980	0.970	1.040	1.030	1.020	0.960
				KLA/Compactin	0.980	1.130	0.970	0.990	1.110	1.040	0.990

Aldh5a1	KLA Compactin Compactin+KLA	NM_172532		aldhehyde dehydrogenase family 5, subfamily A1 (Aldh5a1), mRNA [NM_172532]	KLA	1.000	1.030	0.990	0.970	0.650	0.640	0.840
					Compactin	0.960	1.090	1.070	1.130	0.990	1.050	0.830
					KLA/Compactin	0.970	1.090	1.020	0.980	0.790	0.760	0.850

Bdh1	KLA Compactin Compactin+KLA	NM_001122683	3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), transcript variant 2, mRNA [NM_001122683]	KLA	1.040	1.000	1.000	0.890	1.000	1.110	1.210
				Compactin	1.060	1.030	0.940	1.010	0.950	0.920	0.890
				KLA/Compactin	1.030	0.960	0.920	0.890	0.960	1.140	1.180

Bdh1	KLA Compactin Compactin+KLA	NM_175177		3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_175177]	KLA	0.850	0.940	0.890	0.810	0.880	1.300	1.720
					Compactin	0.870	0.900	0.910	1.030	0.940	0.910	0.870
					KLA/Compactin	0.890	0.950	0.860	0.790	1.040	1.520	1.530

Bdh1	KLA Compactin Compactin+KLA	NM_175177	3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_175177]	KLA	0.940	0.850	0.760	0.750	0.840	1.140	1.490
				Compactin	0.900	0.910	0.900	0.860	0.990	0.830	0.810
				KLA/Compactin	0.760	0.950	0.740	1.310	1.000	1.530	1.750

Bdh2	KLA Compactin Compactin+KLA	NM_027208		3-hydroxybutyrate dehydrogenase, type 2 (Bdh2), mRNA [NM_027208]	KLA	1.030	1.000	1.050	0.990	0.880	0.950	0.990
					Compactin	1.060	1.010	0.980	0.950	1.020	0.990	0.970
					KLA/Compactin	1.080	1.030	1.090	0.940	0.920	0.910	0.950

Bdh2	KLA Compactin Compactin+KLA	NM_027208	3-hydroxybutyrate dehydrogenase, type 2 (Bdh2), mRNA [NM_027208]	KLA	1.180	1.110	1.080	1.320	1.150	1.030	0.720
				Compactin	1.220	1.320	1.160	1.300	0.910	0.750	0.670
				KLA/Compactin	1.120	1.140	1.020	1.370	1.060	0.690	0.510

Echs1	KLA Compactin Compactin+KLA	NM_053119		enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119]	KLA	0.970	0.920	0.850	0.710	0.930	1.420	1.610
					Compactin	0.910	1.040	1.190	1.140	0.930	0.950	1.210
					KLA/Compactin	0.880	0.880	1.030	0.850	0.870	1.240	1.000

Ehhadh	KLA Compactin Compactin+KLA	NM_023737	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737]	KLA	0.980	0.990	0.920	0.970	0.940	1.010	0.990
				Compactin	1.000	1.000	1.010	1.000	0.940	0.960	0.960
				KLA/Compactin	1.030	0.920	1.010	1.010	0.980	1.050	1.000

Gad1	KLA Compactin Compactin+KLA	AK054554		10 days neonate olfactory brain cDNA, RIKEN full-length enriched library, clone:E530004P22 product:glutamic acid decarboxylase 1, full insert sequence. [AK054554]	KLA	0.940	1.010	1.000	0.970	0.970	1.110	1.030
					Compactin	0.900	1.000	0.990	1.000	0.930	0.970	1.000
					KLA/Compactin	1.020	0.990	1.030	1.040	1.040	0.950	0.990

Gad1	KLA Compactin Compactin+KLA	NM_008077	glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]	KLA	1.030	0.950	0.990	1.010	0.950	0.950	1.020
				Compactin	1.060	1.020	1.040	0.980	0.960	0.910	1.050
				KLA/Compactin	0.980	0.970	1.070	1.000	0.940	1.010	0.950

Gad1	KLA Compactin Compactin+KLA	NM_008077		glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]	KLA	1.080	1.020	0.970	1.020	0.960	0.990	0.960
					Compactin	1.090	0.970	1.060	0.970	1.040	1.000	0.930
					KLA/Compactin	0.930	0.970	1.070	1.000	0.950	0.980	1.020

Gad2	KLA Compactin Compactin+KLA	NM_008078	glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078]	KLA	1.000	1.010	1.010	1.000	1.040	1.050	1.050
				Compactin	0.960	0.990	0.960	0.970	0.990	0.970	1.060
				KLA/Compactin	1.050	0.980	0.980	1.080	1.000	0.970	1.020

Gad2	KLA Compactin Compactin+KLA	NM_008078		glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078]	KLA	1.040	0.960	1.060	1.080	1.020	1.000	0.900
					Compactin	0.990	1.000	0.990	1.000	0.950	0.990	0.980
					KLA/Compactin	1.000	1.010	1.030	1.000	0.960	1.080	1.040

Hadh	KLA Compactin Compactin+KLA	NM_008212	hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212]	KLA	0.760	0.890	0.760	0.790	0.580	0.390	0.390
				Compactin	0.950	1.030	0.830	0.760	0.970	0.970	0.760
				KLA/Compactin	0.840	0.850	0.840	0.650	0.520	0.440	0.360

Hadh	KLA Compactin Compactin+KLA	NM_008212		hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212]	KLA	1.000	1.020	1.020	0.830	0.460	0.480	0.420
					Compactin	1.120	1.140	1.120	1.160	1.130	1.050	0.720
					KLA/Compactin	1.010	0.940	1.050	0.810	0.560	0.480	0.420

Hadha	KLA Compactin Compactin+KLA	AK050856	9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert	KLA	0.890	1.000	1.070	0.990	1.030	1.070	0.900
				Compactin	1.060	1.020	0.980	0.990	1.070	0.990	0.980
				KLA/Compactin	0.960	1.060	0.990	1.060	1.000	0.970	0.920

Hadha	KLA Compactin Compactin+KLA	NM_178878		hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878]	KLA	1.060	0.930	0.900	1.160	1.030	1.080	1.510
					Compactin	1.080	0.950	0.940	0.940	1.050	1.070	0.920
					KLA/Compactin	0.950	1.020	0.940	0.980	1.080	1.210	1.590

Hmgcl	KLA Compactin Compactin+KLA	NM_008254	3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), mRNA [NM_008254]	KLA	1.080	0.970	0.880	0.660	1.070	1.170	1.540
				Compactin	1.190	1.060	0.920	1.210	0.990	0.940	1.030
				KLA/Compactin	1.260	0.990	0.800	0.750	1.050	1.390	1.390

Hmgcs1	KLA Compactin Compactin+KLA	AK078743		15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743]	KLA	3.140	1.680	0.790	0.650	0.960	1.080	1.260
					Compactin	1.100	1.040	1.110	1.060	1.120	0.940	1.050
					KLA/Compactin	3.310	2.070	0.950	0.810	1.010	0.870	0.970

Hmgcs1	KLA Compactin Compactin+KLA	NM_145942	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942]	KLA	0.940	1.360	1.370	0.850	0.960	0.930	0.940
				Compactin	1.010	0.940	0.970	1.110	0.990	0.960	0.920
				KLA/Compactin	1.030	1.190	1.530	0.950	1.190	1.130	1.070

Hmgcs1	KLA Compactin Compactin+KLA	NM_145942		3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942]	KLA	1.040	1.650	1.880	0.600	0.900	0.890	0.530
					Compactin	0.910	1.040	1.350	1.360	1.230	1.070	0.920
					KLA/Compactin	1.280	1.510	2.230	0.930	1.210	0.920	0.550

Hmgcs2	KLA Compactin Compactin+KLA	NM_008256	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256]	KLA	1.010	1.030	0.950	1.020	1.040	1.010	0.960
				Compactin	0.990	0.990	1.030	0.980	1.090	1.040	0.980
				KLA/Compactin	1.030	1.040	1.040	0.950	1.000	1.020	0.980

L2hgdh	KLA Compactin Compactin+KLA	NM_145443		L-2-hydroxyglutarate dehydrogenase (L2hgdh), nuclear gene encoding mitochondrial protein, mRNA [NM_145443]	KLA	1.200	0.980	0.980	0.850	0.610	0.570	0.550
					Compactin	1.190	1.080	1.100	1.160	0.960	0.970	0.880
					KLA/Compactin	1.190	1.040	0.950	0.880	0.660	0.490	0.520

Oxct1	KLA Compactin Compactin+KLA	NM_024188	3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188]	KLA	0.840	1.030	1.070	0.640	0.720	0.690	0.610
				Compactin	1.060	1.090	1.060	1.070	1.150	0.860	0.660
				KLA/Compactin	1.180	1.010	0.970	0.800	0.630	0.810	0.550

Oxct1	KLA Compactin Compactin+KLA	NM_024188		3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188]	KLA	1.010	1.030	0.970	0.770	0.820	0.820	0.720
					Compactin	0.910	0.920	0.930	0.910	0.890	0.970	0.810
					KLA/Compactin	0.940	1.010	0.900	0.820	0.740	0.780	0.910

Oxct1	KLA Compactin Compactin+KLA	NM_024188	3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188]	KLA	1.080	0.990	1.060	0.810	0.850	0.800	0.740
				Compactin	1.150	1.120	1.050	1.300	1.020	1.000	0.700
				KLA/Compactin	1.210	1.000	1.090	0.870	0.830	0.900	0.810

Oxct2a	KLA Compactin Compactin+KLA	NM_022033		3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033]	KLA	1.010	1.000	0.960	0.940	0.980	1.010	0.930
					Compactin	0.930	0.940	1.070	1.010	0.990	1.050	1.000
					KLA/Compactin	1.010	0.930	1.030	0.980	0.970	0.930	1.000

Oxct2a	KLA Compactin Compactin+KLA	NM_022033	3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033]	KLA	1.020	1.050	1.040	0.960	0.990	0.930	1.060
				Compactin	0.970	1.020	0.930	1.030	1.050	1.000	0.960
				KLA/Compactin	1.010	0.980	1.050	0.840	0.980	0.960	1.030

Oxct2b	KLA Compactin Compactin+KLA	160358826		3-oxoacid CoA transferase 2B	KLA	1.050	0.990	0.980	1.040	1.030	0.970	0.950
					Compactin	1.030	1.020	1.030	1.040	1.010	0.990	0.940
					KLA/Compactin	0.970	0.950	1.000	0.980	1.000	1.010	1.030

Pdha1	KLA Compactin Compactin+KLA	NM_008810	pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810]	KLA	1.050	1.080	1.140	1.190	1.260	1.730	2.270
				Compactin	1.060	1.190	1.100	1.270	1.020	1.150	1.190
				KLA/Compactin	1.140	1.190	1.130	1.300	1.320	1.690	2.510

Pdha1	KLA Compactin Compactin+KLA	NM_008810		pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810]	KLA	1.200	1.140	1.090	1.160	1.010	0.940	0.870
					Compactin	1.060	1.120	1.040	1.280	1.120	0.900	1.070
					KLA/Compactin	1.150	1.080	1.100	1.160	1.060	1.050	0.760

Pdha2	KLA Compactin Compactin+KLA	NM_008811	pyruvate dehydrogenase E1 alpha 2 (Pdha2), mRNA [NM_008811]	KLA	0.970	1.040	0.940	0.970	1.020	1.100	1.020
				Compactin	0.900	1.030	1.000	0.990	0.940	1.030	1.050
				KLA/Compactin	0.980	0.940	0.980	1.110	0.950	0.970	1.020

Pdhb	KLA Compactin Compactin+KLA	NM_024221		pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221]	KLA	0.930	0.850	0.870	0.950	0.860	0.870	1.010
					Compactin	0.870	0.930	0.820	1.050	0.940	0.860	0.940
					KLA/Compactin	0.820	0.970	0.900	0.780	0.900	0.850	0.740

Pdhb	KLA Compactin Compactin+KLA	NM_024221	pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221]	KLA	0.940	0.920	0.880	0.920	0.990	0.900	0.870
				Compactin	0.760	0.760	0.930	0.790	0.890	0.870	0.860
				KLA/Compactin	0.820	0.840	0.860	1.060	0.810	0.810	0.790

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Butanoate metabolism (mmu00650)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios