Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Glyoxylate and dicarboxylate metabolism (mmu00630)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
1700012G
19Rik
KLA  Compactin  Compactin+KLA
 AK012010 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610311O05 product:hypothetical HAD-like structure containing protein, full insert sequence [AK012010] KLA1.060 0.990 0.790 0.530 0.560 0.590 0.470
Compactin1.200 1.130 1.140 1.130 1.070 0.980 0.790
KLA/Compactin1.090 1.010 0.830 0.520 0.560 0.460 0.560
1700012G
19Rik
KLA  Compactin  Compactin+KLA
 NM_025954 RIKEN cDNA 1700012G19 gene (1700012G19Rik), mRNA [NM_025954] KLA1.100 0.970 0.770 0.490 0.570 0.660 0.560
Compactin1.180 1.060 1.070 1.030 1.070 0.850 0.710
KLA/Compactin1.100 0.970 0.740 0.520 0.510 0.480 0.480
Acat1
KLA  Compactin  Compactin+KLA
 118130035 acetyl-Coenzyme A acetyltransferase 1 KLA0.990 1.040 0.990 0.950 1.030 0.910 0.970
Compactin1.040 1.040 0.960 0.990 1.100 0.980 1.050
KLA/Compactin1.010 1.040 0.960 0.950 0.980 1.040 0.970
Acat1
KLA  Compactin  Compactin+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA1.060 1.000 1.140 1.120 0.890 0.890 0.650
Compactin1.130 1.130 1.170 1.190 0.980 1.080 1.040
KLA/Compactin1.210 1.040 1.190 1.100 0.950 0.850 0.700
Acat2
KLA  Compactin  Compactin+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA0.990 0.960 0.940 1.000 0.740 0.880 0.980
Compactin0.990 1.060 1.190 1.150 1.100 1.090 0.920
KLA/Compactin0.940 1.030 1.020 1.020 0.870 0.880 0.960
Aco1
KLA  Compactin  Compactin+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA1.020 0.960 1.010 1.000 0.920 0.940 0.970
Compactin1.070 1.100 1.040 1.020 1.040 0.960 0.930
KLA/Compactin1.060 1.040 0.980 0.970 0.890 0.870 0.900
Aco1
KLA  Compactin  Compactin+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA1.140 1.090 0.940 0.850 0.880 1.040 0.960
Compactin1.270 1.190 1.140 1.140 1.260 1.060 1.020
KLA/Compactin1.130 1.100 1.060 0.910 1.060 0.980 0.940
Aco2
KLA  Compactin  Compactin+KLA
 AK029122 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122] KLA0.940 1.040 1.020 0.970 1.010 1.040 0.980
Compactin0.990 0.990 1.000 1.020 0.980 0.990 0.910
KLA/Compactin0.940 1.030 0.960 0.970 0.960 0.960 1.060
Aco2
KLA  Compactin  Compactin+KLA
 NM_080633 aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633] KLA1.610 1.480 1.170 1.030 0.860 0.980 1.110
Compactin1.000 1.330 1.540 1.170 1.090 0.880 0.930
KLA/Compactin1.370 1.130 1.320 1.180 0.970 0.960 0.750
Afmid
KLA  Compactin  Compactin+KLA
 31560783 arylformamidase KLA1.120 0.970 1.030 1.090 1.090 1.000 0.730
Compactin1.040 1.020 0.930 0.950 1.000 0.950 0.940
KLA/Compactin1.040 0.950 0.860 1.090 0.950 0.750 0.680
Afmid
KLA  Compactin  Compactin+KLA
 NM_027827 arylformamidase (Afmid), mRNA [NM_027827] KLA1.020 1.050 0.970 0.890 0.860 0.840 0.870
Compactin0.970 0.990 0.980 1.100 0.990 0.990 1.250
KLA/Compactin0.970 1.040 0.870 0.840 0.820 0.770 0.870
Agxt
KLA  Compactin  Compactin+KLA
 NM_016702 alanine-glyoxylate aminotransferase (Agxt), mRNA [NM_016702] KLA1.030 1.050 0.950 0.990 1.060 1.030 0.940
Compactin1.070 0.950 1.010 1.010 1.050 1.050 0.880
KLA/Compactin0.950 0.980 1.080 0.960 0.920 0.970 1.000
Agxt
KLA  Compactin  Compactin+KLA
 NM_016702 alanine-glyoxylate aminotransferase (Agxt), mRNA [NM_016702] KLA1.040 1.020 0.950 1.030 0.880 0.920 0.940
Compactin1.040 1.010 1.040 0.980 1.090 1.010 0.920
KLA/Compactin0.930 1.030 1.040 0.990 1.030 1.020 0.990
Cat
KLA  Compactin  Compactin+KLA
 NM_009804 catalase (Cat), mRNA [NM_009804] KLA0.960 0.950 1.010 0.720 0.810 0.900 1.110
Compactin0.990 1.020 0.970 1.030 1.160 1.090 0.900
KLA/Compactin0.990 0.950 0.990 0.800 0.840 1.150 1.430
Cs
KLA  Compactin  Compactin+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA1.010 0.960 1.060 0.940 0.790 0.970 0.950
Compactin1.060 0.950 1.120 1.190 1.000 1.090 1.080
KLA/Compactin1.160 1.020 1.020 1.010 0.920 0.860 0.720
Cs
KLA  Compactin  Compactin+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA1.170 1.140 1.160 1.090 1.070 1.280 1.460
Compactin1.180 1.140 1.120 1.250 1.080 1.020 1.120
KLA/Compactin1.230 1.070 1.140 1.260 1.130 1.090 1.660
Csl
KLA  Compactin  Compactin+KLA
 NM_027945 citrate synthase like (Csl), mRNA [NM_027945] KLA0.880 0.970 0.880 1.070 1.080 0.940 1.590
Compactin0.960 0.880 0.780 0.790 1.120 1.050 0.880
KLA/Compactin0.970 1.020 0.920 0.910 0.960 1.440 1.770
Gcsh
KLA  Compactin  Compactin+KLA
 NM_026572 glycine cleavage system protein H (aminomethyl carrier) (Gcsh), mRNA [NM_026572] KLA1.070 1.030 1.140 0.990 0.870 0.850 0.870
Compactin1.110 1.200 1.090 1.180 1.060 1.110 1.300
KLA/Compactin1.040 1.070 1.250 0.890 0.880 0.840 0.950
Glul
KLA  Compactin  Compactin+KLA
 NM_008131 glutamate-ammonia ligase (glutamine synthetase) (Glul), mRNA [NM_008131] KLA0.990 1.040 1.040 0.930 0.860 0.980 1.420
Compactin1.060 1.000 0.950 1.010 0.950 0.950 0.930
KLA/Compactin1.030 1.030 1.070 0.940 1.090 1.100 1.370
Glul
KLA  Compactin  Compactin+KLA
 NM_008131 glutamate-ammonia ligase (glutamine synthetase) (Glul), mRNA [NM_008131] KLA1.110 1.070 0.950 0.870 0.680 0.650 0.790
Compactin1.070 1.110 1.020 1.150 1.090 1.030 1.090
KLA/Compactin1.050 1.040 0.940 0.790 0.830 0.940 0.810
Glul
KLA  Compactin  Compactin+KLA
 X16314 gb|M.musculus mRNA for glutamine synthetase. [X16314] KLA0.990 0.970 0.980 1.020 0.970 1.040 0.970
Compactin1.050 0.980 0.990 1.060 0.890 1.030 0.990
KLA/Compactin1.070 1.020 0.950 0.940 1.000 0.920 1.060
Glyctk
KLA  Compactin  Compactin+KLA
 NM_174846 glycerate kinase (Glyctk), transcript variant 1, mRNA [NM_174846] KLA0.990 0.960 0.980 0.970 0.960 0.960 0.910
Compactin0.990 0.950 1.020 1.030 0.950 0.980 0.980
KLA/Compactin1.040 0.940 0.950 1.020 1.010 0.880 0.900
Glyctk
KLA  Compactin  Compactin+KLA
 NM_174846 glycerate kinase (Glyctk), transcript variant 1, mRNA [NM_174846] KLA1.010 1.010 1.020 1.090 1.010 1.090 0.980
Compactin1.020 1.010 0.960 1.000 1.030 1.040 0.970
KLA/Compactin1.010 1.180 1.040 1.030 1.020 1.050 0.930
Grhpr
KLA  Compactin  Compactin+KLA
 NM_080289 glyoxylate reductase/hydroxypyruvate reductase (Grhpr), mRNA [NM_080289] KLA0.980 1.020 0.960 1.020 0.740 0.870 1.010
Compactin1.050 1.160 1.040 1.210 1.030 1.030 1.170
KLA/Compactin1.130 1.170 0.920 1.010 0.840 1.000 1.020
Hao1
KLA  Compactin  Compactin+KLA
 AF104312 glycolate oxidase mRNA, complete cds. [AF104312] KLA0.980 0.990 1.070 1.020 1.090 1.080 1.060
Compactin1.000 1.050 1.030 0.990 0.960 0.950 1.030
KLA/Compactin1.050 1.010 0.980 0.980 1.030 1.030 1.060
Hao3
KLA  Compactin  Compactin+KLA
 NM_019545 hydroxyacid oxidase (glycolate oxidase) 3 (Hao3), mRNA [NM_019545] KLA1.020 0.990 0.970 1.050 0.990 1.030 1.020
Compactin1.100 0.970 0.980 0.980 0.980 0.960 1.000
KLA/Compactin1.000 1.000 1.060 1.040 0.990 1.060 1.010
Hyi
KLA  Compactin  Compactin+KLA
 NM_026601 hydroxypyruvate isomerase homolog (E. coli) (Hyi), mRNA [NM_026601] KLA0.910 0.880 0.800 0.830 0.770 0.750 1.150
Compactin1.090 1.030 0.940 0.930 1.120 0.930 1.100
KLA/Compactin0.850 0.770 0.710 0.830 0.850 1.170 1.460
Mcee
KLA  Compactin  Compactin+KLA
 NM_028626 methylmalonyl CoA epimerase (Mcee), mRNA [NM_028626] KLA0.960 0.990 0.880 0.990 0.820 0.830 1.200
Compactin0.990 1.090 1.080 0.990 0.990 0.870 0.850
KLA/Compactin0.920 0.870 0.960 1.020 0.820 0.890 1.190
Mdh1
KLA  Compactin  Compactin+KLA
 AK077724 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724] KLA0.770 0.750 0.810 0.650 0.850 0.880 0.910
Compactin1.040 1.050 1.010 0.960 1.050 0.860 1.060
KLA/Compactin0.760 0.710 0.790 0.700 0.820 0.800 0.880
Mdh1
KLA  Compactin  Compactin+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA1.020 0.980 1.020 0.860 0.570 0.600 0.650
Compactin1.070 1.030 1.160 1.140 1.100 1.040 0.860
KLA/Compactin1.090 0.970 0.930 0.950 0.620 0.580 0.590
Mdh1
KLA  Compactin  Compactin+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA1.050 1.000 0.780 0.770 0.870 0.550 0.560
Compactin0.960 1.040 1.100 0.890 1.170 1.150 1.060
KLA/Compactin0.810 0.900 0.920 0.790 0.570 0.490 0.710
Mdh2
KLA  Compactin  Compactin+KLA
 NM_008617 malate dehydrogenase 2, NAD (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA [NM_008617] KLA0.970 0.790 0.930 0.880 0.950 0.940 0.940
Compactin0.930 0.910 0.970 0.960 1.010 0.930 0.910
KLA/Compactin0.980 0.810 0.980 0.800 0.870 0.890 0.910
Mut
KLA  Compactin  Compactin+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA0.940 0.880 0.700 0.840 0.750 0.570 0.580
Compactin0.950 0.860 0.760 0.890 0.870 1.040 0.770
KLA/Compactin0.820 0.840 0.740 0.670 0.590 0.640 0.610
Mut
KLA  Compactin  Compactin+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA0.970 0.920 0.920 0.760 0.620 0.730 0.560
Compactin1.020 1.060 1.060 1.130 0.860 0.930 0.860
KLA/Compactin1.080 0.960 0.860 0.790 0.700 0.790 0.460
Mut
KLA  Compactin  Compactin+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA0.990 0.910 0.930 0.650 0.570 0.740 0.600
Compactin1.120 0.910 1.040 1.080 0.910 1.030 0.800
KLA/Compactin1.150 0.890 0.930 0.830 0.610 0.660 0.540
Pcca
KLA  Compactin  Compactin+KLA
 NM_144844 propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca), mRNA [NM_144844] KLA1.120 1.010 1.190 1.110 0.920 0.910 1.470
Compactin1.140 1.140 1.140 1.150 1.050 1.080 0.890
KLA/Compactin1.140 1.040 1.100 1.130 0.860 0.900 1.380
Pccb
KLA  Compactin  Compactin+KLA
 NM_025835 propionyl Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA [NM_025835] KLA0.970 0.970 0.980 0.900 0.810 0.740 0.730
Compactin1.070 1.030 1.020 1.080 0.990 0.990 0.810
KLA/Compactin1.020 0.960 0.990 0.990 0.790 0.750 0.720
Shmt1
KLA  Compactin  Compactin+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA0.870 1.060 0.980 0.760 0.850 0.700 0.740
Compactin1.130 0.900 0.960 0.870 0.850 1.120 0.770
KLA/Compactin0.780 1.050 0.850 0.830 0.560 0.610 0.870
Shmt1
KLA  Compactin  Compactin+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA0.990 0.970 1.060 0.850 0.520 0.540 0.430
Compactin1.020 1.030 1.020 1.010 0.940 0.950 0.690
KLA/Compactin0.910 1.120 0.910 0.680 0.480 0.410 0.430
Shmt1
KLA  Compactin  Compactin+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA1.140 1.210 1.160 0.930 0.780 0.800 0.720
Compactin1.150 1.090 1.100 1.120 0.960 0.980 0.840
KLA/Compactin1.110 1.220 1.230 1.010 0.700 0.580 0.810
Shmt2
KLA  Compactin  Compactin+KLA
 NM_028230 serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, mRNA [NM_028230] KLA1.030 1.060 0.880 0.810 0.840 0.990 0.910
Compactin1.070 1.050 1.140 1.090 1.070 0.950 1.020
KLA/Compactin1.070 1.050 1.090 0.860 0.780 1.010 0.690