Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Other glycan degradation (mmu00511)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
Aga	KLA Compactin Compactin+KLA	NM_001005847	aspartylglucosaminidase (Aga), mRNA [NM_001005847]	KLA	0.900	0.860	0.870	1.050	1.000	0.930	1.200
				Compactin	0.880	0.840	0.890	0.780	0.950	0.870	0.940
				KLA/Compactin	0.960	0.960	0.970	0.830	0.840	0.900	1.110

AK209324	KLA Compactin Compactin+KLA	AK209324		cDNA, clone:Y2G0114L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060207, based on BLAT search. [AK209324]	KLA	0.880	0.650	1.030	0.930	1.150	0.940	0.680
					Compactin	1.180	1.090	1.030	0.970	1.050	0.980	0.980
					KLA/Compactin	0.950	0.650	0.990	0.860	1.040	0.700	0.560

D230014K 01Rik	KLA Compactin Compactin+KLA	NM_172573	RIKEN cDNA D230014K01 gene (D230014K01Rik), mRNA [NM_172573]	KLA	0.940	0.740	0.750	0.740	0.820	0.730	0.760
				Compactin	1.060	1.010	1.100	1.100	1.020	0.950	0.900
				KLA/Compactin	0.950	0.780	0.760	0.820	0.780	0.660	0.690

D230014K 01Rik	KLA Compactin Compactin+KLA	NM_172573		RIKEN cDNA D230014K01 gene (D230014K01Rik), mRNA [NM_172573]	KLA	0.960	0.960	0.930	0.870	0.780	0.840	0.820
					Compactin	1.030	1.070	1.050	1.080	0.960	0.970	0.960
					KLA/Compactin	0.970	1.000	1.040	1.030	0.820	0.890	0.780

Fuca1	KLA Compactin Compactin+KLA	NM_024243	fucosidase, alpha-L- 1, tissue (Fuca1), mRNA [NM_024243]	KLA	1.010	1.010	1.120	1.010	0.840	0.860	1.060
				Compactin	1.230	1.040	1.260	1.270	1.130	1.100	1.130
				KLA/Compactin	1.160	1.020	1.050	0.990	0.800	0.880	1.230

Fuca1	KLA Compactin Compactin+KLA	NM_024243		fucosidase, alpha-L- 1, tissue (Fuca1), mRNA [NM_024243]	KLA	1.120	0.970	1.090	0.990	0.760	0.800	1.050
					Compactin	1.190	1.070	1.080	1.210	0.960	1.010	0.980
					KLA/Compactin	1.180	1.030	1.080	0.990	0.810	0.740	1.060

Fuca2	KLA Compactin Compactin+KLA	NM_025799	fucosidase, alpha-L- 2, plasma (Fuca2), mRNA [NM_025799]	KLA	0.940	1.010	0.960	0.990	0.990	0.950	0.880
				Compactin	1.020	1.010	1.040	1.020	0.970	0.990	0.950
				KLA/Compactin	0.990	1.000	0.980	1.060	0.930	0.960	0.870

Fuca2	KLA Compactin Compactin+KLA	NM_025799		fucosidase, alpha-L- 2, plasma (Fuca2), mRNA [NM_025799]	KLA	1.010	1.050	1.060	0.850	0.770	0.910	0.700
					Compactin	1.120	1.080	1.240	0.840	0.900	0.840	0.740
					KLA/Compactin	1.010	0.950	1.060	0.950	0.640	0.760	0.600

Gba	KLA Compactin Compactin+KLA	NM_001077411	glucosidase, beta, acid (Gba), mRNA [NM_001077411]	KLA	1.190	1.090	1.140	1.050	1.340	1.900	2.930
				Compactin	1.190	1.130	1.160	1.110	0.790	0.900	0.920
				KLA/Compactin	1.080	1.030	1.080	1.200	1.120	1.610	3.270

Gba2	KLA Compactin Compactin+KLA	NM_172692		glucosidase beta 2 (Gba2), mRNA [NM_172692]	KLA	0.890	0.750	0.930	0.850	0.870	1.000	0.900
					Compactin	0.870	0.970	0.950	1.020	1.000	1.010	1.180
					KLA/Compactin	0.940	0.820	0.950	0.790	0.960	0.970	0.640

Gba2	KLA Compactin Compactin+KLA	NM_172692	glucosidase beta 2 (Gba2), mRNA [NM_172692]	KLA	1.040	0.870	1.000	0.940	0.920	1.010	0.890
				Compactin	0.990	1.020	1.050	1.010	1.030	0.990	1.150
				KLA/Compactin	1.010	0.890	0.940	1.010	0.940	0.980	0.680

Glb1	KLA Compactin Compactin+KLA	NM_009752		galactosidase, beta 1 (Glb1), mRNA [NM_009752]	KLA	0.930	0.960	1.060	0.950	0.970	1.000	1.320
					Compactin	1.010	0.960	1.020	1.050	0.970	0.990	1.030
					KLA/Compactin	1.130	0.950	1.020	0.990	0.900	0.950	1.210

Glb1	KLA Compactin Compactin+KLA	NM_009752	galactosidase, beta 1 (Glb1), mRNA [NM_009752]	KLA	1.130	1.140	1.090	1.050	0.940	1.080	1.350
				Compactin	1.220	1.150	1.170	1.250	0.990	1.110	1.160
				KLA/Compactin	1.290	1.170	1.160	0.940	0.940	1.050	1.180

Glb1	KLA Compactin Compactin+KLA	NM_009752		galactosidase, beta 1 (Glb1), mRNA [NM_009752]	KLA	1.300	1.220	1.300	1.220	0.950	1.030	1.360
					Compactin	1.330	1.190	1.310	1.170	1.280	1.160	1.020
					KLA/Compactin	1.330	1.050	1.190	1.240	0.980	1.040	1.150

Hexa	KLA Compactin Compactin+KLA	NM_010421	hexosaminidase A (Hexa), mRNA [NM_010421]	KLA	1.110	0.990	0.970	0.990	0.880	0.850	0.780
				Compactin	1.180	1.110	1.120	1.170	0.940	0.890	0.700
				KLA/Compactin	1.180	1.030	0.950	0.980	0.740	0.730	0.680

Hexb	KLA Compactin Compactin+KLA	NM_010422		hexosaminidase B (Hexb), mRNA [NM_010422]	KLA	1.110	1.030	1.020	0.940	0.600	0.580	0.730
					Compactin	1.150	1.100	1.100	1.130	1.100	1.040	0.950
					KLA/Compactin	1.270	1.070	0.920	0.930	0.670	0.590	0.610

Hexdc	KLA Compactin Compactin+KLA	47679083	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	KLA	0.970	0.930	0.810	0.680	0.630	0.710	1.030
				Compactin	0.940	0.980	0.990	0.870	1.080	1.080	1.080
				KLA/Compactin	0.990	0.960	0.880	0.630	0.540	0.710	1.050

Hexdc	KLA Compactin Compactin+KLA	NM_001001333		hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing (Hexdc), mRNA [NM_001001333]	KLA	0.950	1.000	0.880	0.790	0.610	0.740	1.080
					Compactin	1.000	1.040	1.000	1.020	1.150	1.180	1.000
					KLA/Compactin	0.990	1.150	0.880	0.740	0.630	0.670	1.250

Man2b1	KLA Compactin Compactin+KLA	AK054315	2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330014I09 product:mannosidase 2, alpha B1, full insert sequence. [AK054315]	KLA	0.980	0.950	1.010	0.990	1.010	1.050	1.000
				Compactin	0.990	0.940	0.970	1.000	1.020	1.020	0.980
				KLA/Compactin	0.980	0.960	1.020	0.980	0.980	1.020	0.960

Man2b1	KLA Compactin Compactin+KLA	NM_010764		mannosidase 2, alpha B1 (Man2b1), mRNA [NM_010764]	KLA	1.110	1.070	1.130	0.860	0.700	0.590	0.420
					Compactin	1.180	1.050	1.180	1.080	1.060	1.130	0.830
					KLA/Compactin	1.220	0.970	1.110	1.030	0.640	0.510	0.410

Man2b2	KLA Compactin Compactin+KLA	NM_008550	mannosidase 2, alpha B2 (Man2b2), mRNA [NM_008550]	KLA	1.020	0.960	0.790	0.910	1.440	1.000	1.290
				Compactin	0.900	0.950	1.010	0.700	1.070	1.150	1.110
				KLA/Compactin	0.850	0.990	1.080	0.980	0.790	1.150	2.050

Man2c1	KLA Compactin Compactin+KLA	NM_028636		mannosidase, alpha, class 2C, member 1 (Man2c1), mRNA [NM_028636]	KLA	0.900	0.820	0.750	0.690	0.720	0.760	0.710
					Compactin	0.870	0.930	0.900	0.720	1.000	0.960	0.930
					KLA/Compactin	0.880	0.800	0.710	0.780	0.860	0.890	0.960

Man2c1	KLA Compactin Compactin+KLA	NM_028636	mannosidase, alpha, class 2C, member 1 (Man2c1), mRNA [NM_028636]	KLA	0.970	0.990	1.010	0.960	1.070	1.020	1.090
				Compactin	0.930	0.970	0.990	0.980	1.000	1.040	0.960
				KLA/Compactin	1.020	0.940	1.090	0.990	1.060	1.160	1.060

Man2c1	KLA Compactin Compactin+KLA	NM_028636		mannosidase, alpha, class 2C, member 1 (Man2c1), mRNA [NM_028636]	KLA	1.010	1.080	1.030	0.960	1.010	0.990	1.070
					Compactin	0.970	0.990	1.080	0.930	1.090	0.980	1.100
					KLA/Compactin	0.910	1.060	1.040	0.950	1.000	1.150	1.120

Manba	KLA Compactin Compactin+KLA	AK037629	16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130030I04 product:unclassifiable, full insert sequence. [AK037629]	KLA	1.000	0.990	0.990	1.060	0.980	0.980	0.950
				Compactin	1.050	1.020	1.020	1.020	1.100	1.020	0.990
				KLA/Compactin	1.010	1.060	0.930	0.990	1.050	1.010	1.010

Manba	KLA Compactin Compactin+KLA	NM_027288		mannosidase, beta A, lysosomal (Manba), mRNA [NM_027288]	KLA	1.000	1.040	1.040	0.680	0.600	0.870	0.960
					Compactin	1.020	0.980	0.980	1.020	0.890	0.740	0.830
					KLA/Compactin	1.030	1.020	0.970	0.650	0.560	0.800	0.890

Manba	KLA Compactin Compactin+KLA	NM_027288	mannosidase, beta A, lysosomal (Manba), mRNA [NM_027288]	KLA	1.140	1.110	1.110	0.730	0.710	0.900	0.840
				Compactin	1.160	1.160	1.150	1.150	0.850	0.800	0.910
				KLA/Compactin	1.250	1.100	1.090	0.730	0.580	0.690	0.830

Neu1	KLA Compactin Compactin+KLA	NM_010893		neuraminidase 1 (Neu1), mRNA [NM_010893]	KLA	0.750	0.860	0.720	0.710	1.230	1.280	2.050
					Compactin	0.990	1.000	0.770	0.780	0.940	0.960	0.880
					KLA/Compactin	0.910	0.900	0.730	0.560	0.790	1.550	1.920

Neu1	KLA Compactin Compactin+KLA	NM_010893	neuraminidase 1 (Neu1), mRNA [NM_010893]	KLA	1.070	1.040	0.840	0.690	1.120	1.750	2.190
				Compactin	1.100	1.070	0.990	1.130	0.810	0.830	1.000
				KLA/Compactin	1.150	0.930	0.840	0.690	0.920	1.330	1.870

Neu2	KLA Compactin Compactin+KLA	NM_015750		neuraminidase 2 (Neu2), mRNA [NM_015750]	KLA	1.080	0.950	1.000	1.050	0.950	0.980	1.080
					Compactin	0.920	1.010	0.960	0.990	1.180	1.060	1.020
					KLA/Compactin	0.940	1.060	0.980	1.010	1.170	1.180	1.160

Neu3	KLA Compactin Compactin+KLA	118131105	neuraminidase 3	KLA	0.890	1.020	0.940	1.070	0.980	1.030	0.950
				Compactin	0.950	1.060	1.020	0.990	0.960	0.870	1.050
				KLA/Compactin	1.030	0.930	0.930	1.040	1.500	1.180	1.000

Neu3	KLA Compactin Compactin+KLA	NM_016720		neuraminidase 3 (Neu3), mRNA [NM_016720]	KLA	1.000	0.940	0.990	1.100	1.060	1.040	1.060
					Compactin	1.010	1.030	1.100	1.080	1.050	0.940	1.150
					KLA/Compactin	1.080	0.980	1.020	1.150	1.050	1.150	1.030

Neu4	KLA Compactin Compactin+KLA	NM_173772	sialidase 4 (Neu4), mRNA [NM_173772]	KLA	1.050	0.960	0.980	1.060	1.000	0.980	0.990
				Compactin	1.000	1.010	0.940	1.050	1.040	1.000	1.020
				KLA/Compactin	1.030	0.960	0.880	0.980	1.040	1.030	1.060

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Other glycan degradation (mmu00511)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios