Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: beta-Alanine metabolism (mmu00410)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
1700055N 04Rik	KLA Compactin Compactin+KLA	94405716	RIKEN cDNA 1700055N04 gene	KLA	0.910	0.920	1.020	1.030	0.920	0.840	1.020
				Compactin	1.040	1.010	0.940	0.990	0.910	1.010	0.910
				KLA/Compactin	0.940	1.020	1.010	1.020	0.940	1.030	1.080

1700055N 04Rik	KLA Compactin Compactin+KLA	AK081788		16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788]	KLA	0.980	0.950	0.940	0.960	0.990	1.020	1.030
					Compactin	1.050	0.970	0.970	1.020	1.050	1.010	0.880
					KLA/Compactin	1.000	1.010	0.970	1.010	1.020	0.980	1.000

Abat	KLA Compactin Compactin+KLA	AK083062	12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062]	KLA	1.000	0.960	1.000	1.000	1.050	0.950	1.020
				Compactin	1.070	1.010	1.010	1.000	1.010	1.010	0.980
				KLA/Compactin	1.010	1.020	1.030	1.010	1.020	0.990	1.070

Abat	KLA Compactin Compactin+KLA	NM_172961		4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961]	KLA	0.980	1.020	1.000	0.950	1.010	0.960	1.030
					Compactin	0.990	1.020	0.950	1.060	1.030	1.020	0.990
					KLA/Compactin	1.020	0.980	0.990	0.950	1.000	0.990	0.990

Acadm	KLA Compactin Compactin+KLA	NM_007382	acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382]	KLA	0.980	0.830	0.580	0.570	0.770	0.630	0.420
				Compactin	0.940	0.970	1.020	0.780	1.060	1.260	1.140
				KLA/Compactin	0.850	0.900	0.840	0.550	0.610	0.700	0.650

AI790298	KLA Compactin Compactin+KLA	AK129347		mRNA for mKIAA1394 protein [AK129347]	KLA	1.010	0.990	0.990	1.040	1.010	1.070	1.020
					Compactin	1.030	1.010	0.960	1.030	0.970	0.980	1.010
					KLA/Compactin	0.940	1.010	1.050	1.020	1.000	0.950	0.930

Aldh1a3	KLA Compactin Compactin+KLA	AK086764	15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764]	KLA	1.000	1.030	0.980	1.000	1.020	1.060	0.940
				Compactin	1.020	1.020	1.060	1.050	1.010	0.980	1.040
				KLA/Compactin	0.990	1.270	0.990	1.080	1.020	0.970	1.030

Aldh1a3	KLA Compactin Compactin+KLA	NM_053080		aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080]	KLA	1.010	1.070	1.000	0.950	1.090	1.020	1.050
					Compactin	0.910	1.000	1.050	0.970	0.920	1.020	1.020
					KLA/Compactin	0.980	0.940	1.020	1.000	0.970	0.930	1.040

Aldh1b1	KLA Compactin Compactin+KLA	NM_028270	aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270]	KLA	0.990	0.930	1.090	2.540	4.350	5.420	5.340
				Compactin	1.030	0.980	1.040	1.190	0.880	0.810	1.090
				KLA/Compactin	0.970	0.900	1.030	2.940	5.190	6.900	5.710

Aldh2	KLA Compactin Compactin+KLA	AK163452		adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452]	KLA	0.980	1.050	1.010	0.980	1.000	1.030	1.060
					Compactin	1.050	1.010	1.010	1.030	1.070	1.030	0.970
					KLA/Compactin	0.990	1.000	1.030	0.950	1.030	0.960	1.050

Aldh2	KLA Compactin Compactin+KLA	NM_009656	aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656]	KLA	0.940	0.930	0.960	0.980	0.830	0.900	0.880
				Compactin	1.080	0.910	0.930	1.150	1.580	1.000	0.840
				KLA/Compactin	1.050	1.030	1.050	0.790	1.020	0.880	0.860

Aldh3a1	KLA Compactin Compactin+KLA	NM_007436		aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436]	KLA	1.010	1.050	1.100	0.970	0.990	1.000	0.960
					Compactin	0.980	1.010	1.010	0.980	1.050	0.970	1.040
					KLA/Compactin	1.000	1.000	0.960	1.070	1.020	1.020	1.040

Aldh3a2	KLA Compactin Compactin+KLA	NM_007437	aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437]	KLA	1.040	0.900	0.840	0.840	1.130	1.330	1.150
				Compactin	1.020	1.070	0.990	1.170	1.000	0.960	1.110
				KLA/Compactin	1.110	0.870	0.880	0.930	1.320	1.440	1.120

Aldh3b1	KLA Compactin Compactin+KLA	NM_026316		aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316]	KLA	0.990	1.030	1.100	1.000	0.840	1.250	1.060
					Compactin	1.120	1.100	1.310	1.250	0.960	1.020	0.850
					KLA/Compactin	1.170	1.050	1.070	1.040	0.980	1.140	0.940

Aldh3b2	KLA Compactin Compactin+KLA	94405693	aldehyde dehydrogenase 3 family, member B2	KLA	1.010	1.010	0.960	0.970	0.940	1.030	0.980
				Compactin	1.050	1.080	0.980	1.010	1.150	0.980	1.020
				KLA/Compactin	0.980	0.950	1.000	1.020	0.980	1.000	1.050

Aldh3b2	KLA Compactin Compactin+KLA	XM_129134		gb\|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134]	KLA	0.900	0.870	0.920	0.990	1.040	1.080	1.040
					Compactin	0.860	0.950	0.900	0.930	0.920	0.950	0.850
					KLA/Compactin	0.940	0.880	0.890	1.040	0.880	1.010	1.150

Aldh6a1	KLA Compactin Compactin+KLA	NM_134042	aldehyde dehydrogenase family 6, subfamily A1 (Aldh6a1), nuclear gene encoding mitochondrial protein, mRNA [NM_134042]	KLA	0.950	0.950	0.840	0.760	0.860	1.260	1.960
				Compactin	0.940	1.020	1.000	1.100	1.120	0.940	1.080
				KLA/Compactin	0.950	0.900	0.910	0.820	1.010	1.650	2.190

Aldh7a1	KLA Compactin Compactin+KLA	NM_138600		aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600]	KLA	0.970	0.980	0.980	1.060	1.020	1.080	1.220
					Compactin	1.000	1.070	0.990	1.010	0.950	0.980	0.990
					KLA/Compactin	1.000	1.020	1.010	1.150	1.070	1.060	1.260

Aldh7a1	KLA Compactin Compactin+KLA	NM_138600	aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600]	KLA	1.000	0.990	1.000	1.070	1.060	1.000	1.010
				Compactin	0.990	0.950	1.010	0.990	0.970	0.950	1.000
				KLA/Compactin	1.060	1.010	0.990	0.990	0.920	1.020	0.960

Aldh9a1	KLA Compactin Compactin+KLA	NM_019993		aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993]	KLA	0.900	0.880	0.920	0.850	0.780	0.700	0.750
					Compactin	0.890	0.960	0.920	0.920	1.080	1.090	0.980
					KLA/Compactin	0.840	0.950	0.950	0.850	0.750	0.710	0.870

Aldh9a1	KLA Compactin Compactin+KLA	NM_019993	aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993]	KLA	0.930	0.840	0.770	0.830	0.740	0.590	0.640
				Compactin	0.870	0.870	0.910	0.930	0.990	0.980	0.980
				KLA/Compactin	0.890	0.960	0.890	0.710	0.660	0.600	0.630

Aldh9a1	KLA Compactin Compactin+KLA	NM_019993		aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993]	KLA	1.020	0.950	0.990	0.900	0.680	0.660	0.630
					Compactin	1.180	1.040	1.120	1.230	1.070	1.030	0.960
					KLA/Compactin	1.110	0.940	1.000	0.880	0.670	0.650	0.700

Aoc2	KLA Compactin Compactin+KLA	NM_178932	amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932]	KLA	1.330	2.340	1.120	1.060	1.120	1.050	1.300
				Compactin	0.970	0.990	0.990	0.990	1.010	0.930	1.160
				KLA/Compactin	1.360	2.290	1.100	1.090	1.070	0.920	1.290

Aoc3	KLA Compactin Compactin+KLA	NM_009675		amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675]	KLA	0.960	1.060	1.040	1.070	1.050	1.040	1.030
					Compactin	0.960	1.070	0.970	0.960	1.020	1.050	1.020
					KLA/Compactin	0.980	0.990	1.000	0.950	1.000	1.030	1.030

Cndp1	KLA Compactin Compactin+KLA	NM_177450	carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1), mRNA [NM_177450]	KLA	1.040	0.990	0.970	0.990	1.020	1.000	0.970
				Compactin	1.030	1.020	1.050	1.060	1.000	1.020	0.920
				KLA/Compactin	1.000	0.980	0.960	0.950	1.050	1.050	0.950

Cndp2	KLA Compactin Compactin+KLA	NM_023149		CNDP dipeptidase 2 (metallopeptidase M20 family) (Cndp2), mRNA [NM_023149]	KLA	1.220	1.120	1.350	1.810	3.020	3.910	3.700
					Compactin	1.140	1.120	1.160	1.120	1.050	1.070	1.230
					KLA/Compactin	1.130	1.050	1.270	1.740	3.210	2.930	3.450

Dpyd	KLA Compactin Compactin+KLA	NM_170778	dihydropyrimidine dehydrogenase (Dpyd), mRNA [NM_170778]	KLA	1.080	0.980	0.940	0.970	1.000	1.040	1.030
				Compactin	0.890	1.070	0.960	1.050	0.920	0.970	0.990
				KLA/Compactin	0.930	0.940	1.010	1.010	0.980	0.980	1.020

Dpys	KLA Compactin Compactin+KLA	NM_022722		dihydropyrimidinase (Dpys), mRNA [NM_022722]	KLA	0.980	1.000	1.020	1.030	1.020	1.020	1.100
					Compactin	1.050	0.960	0.990	0.930	1.020	1.020	0.960
					KLA/Compactin	0.990	1.030	0.880	0.970	1.080	1.040	1.040

Echs1	KLA Compactin Compactin+KLA	NM_053119	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119]	KLA	0.970	0.920	0.850	0.710	0.930	1.420	1.610
				Compactin	0.910	1.040	1.190	1.140	0.930	0.950	1.210
				KLA/Compactin	0.880	0.880	1.030	0.850	0.870	1.240	1.000

Ehhadh	KLA Compactin Compactin+KLA	NM_023737		enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737]	KLA	0.980	0.990	0.920	0.970	0.940	1.010	0.990
					Compactin	1.000	1.000	1.010	1.000	0.940	0.960	0.960
					KLA/Compactin	1.030	0.920	1.010	1.010	0.980	1.050	1.000

Gad1	KLA Compactin Compactin+KLA	AK054554	10 days neonate olfactory brain cDNA, RIKEN full-length enriched library, clone:E530004P22 product:glutamic acid decarboxylase 1, full insert sequence. [AK054554]	KLA	0.940	1.010	1.000	0.970	0.970	1.110	1.030
				Compactin	0.900	1.000	0.990	1.000	0.930	0.970	1.000
				KLA/Compactin	1.020	0.990	1.030	1.040	1.040	0.950	0.990

Gad1	KLA Compactin Compactin+KLA	NM_008077		glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]	KLA	1.030	0.950	0.990	1.010	0.950	0.950	1.020
					Compactin	1.060	1.020	1.040	0.980	0.960	0.910	1.050
					KLA/Compactin	0.980	0.970	1.070	1.000	0.940	1.010	0.950

Gad1	KLA Compactin Compactin+KLA	NM_008077	glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]	KLA	1.080	1.020	0.970	1.020	0.960	0.990	0.960
				Compactin	1.090	0.970	1.060	0.970	1.040	1.000	0.930
				KLA/Compactin	0.930	0.970	1.070	1.000	0.950	0.980	1.020

Gad2	KLA Compactin Compactin+KLA	NM_008078		glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078]	KLA	1.000	1.010	1.010	1.000	1.040	1.050	1.050
					Compactin	0.960	0.990	0.960	0.970	0.990	0.970	1.060
					KLA/Compactin	1.050	0.980	0.980	1.080	1.000	0.970	1.020

Gad2	KLA Compactin Compactin+KLA	NM_008078	glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078]	KLA	1.040	0.960	1.060	1.080	1.020	1.000	0.900
				Compactin	0.990	1.000	0.990	1.000	0.950	0.990	0.980
				KLA/Compactin	1.000	1.010	1.030	1.000	0.960	1.080	1.040

Hadha	KLA Compactin Compactin+KLA	AK050856		9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert	KLA	0.890	1.000	1.070	0.990	1.030	1.070	0.900
					Compactin	1.060	1.020	0.980	0.990	1.070	0.990	0.980
					KLA/Compactin	0.960	1.060	0.990	1.060	1.000	0.970	0.920

Hadha	KLA Compactin Compactin+KLA	NM_178878	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878]	KLA	1.060	0.930	0.900	1.160	1.030	1.080	1.510
				Compactin	1.080	0.950	0.940	0.940	1.050	1.070	0.920
				KLA/Compactin	0.950	1.020	0.940	0.980	1.080	1.210	1.590

Hibch	KLA Compactin Compactin+KLA	NM_146108		3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch), mRNA [NM_146108]	KLA	1.050	1.100	1.080	0.870	0.870	1.190	1.370
					Compactin	1.010	1.130	1.240	1.030	0.990	0.990	0.960
					KLA/Compactin	0.940	1.140	1.110	0.920	0.830	1.380	1.380

Mlycd	KLA Compactin Compactin+KLA	NM_019966	malonyl-CoA decarboxylase (Mlycd), nuclear gene encoding mitochondrial protein, mRNA [NM_019966]	KLA	0.810	0.770	0.660	0.650	0.600	0.730	0.670
				Compactin	0.870	0.960	0.900	1.020	0.930	0.970	0.900
				KLA/Compactin	0.960	0.890	0.630	0.580	0.810	0.720	0.530

Sms	KLA Compactin Compactin+KLA	NM_009214		spermine synthase (Sms), mRNA [NM_009214]	KLA	0.870	0.830	0.730	0.900	1.040	0.820	0.750
					Compactin	0.800	0.920	0.980	0.780	0.940	1.100	0.930
					KLA/Compactin	0.840	0.820	1.000	0.840	0.770	0.770	0.880

Sms	KLA Compactin Compactin+KLA	NM_009214	spermine synthase (Sms), mRNA [NM_009214]	KLA	1.020	1.030	1.160	1.130	0.970	0.940	0.650
				Compactin	1.060	1.050	1.040	0.990	0.900	0.890	0.930
				KLA/Compactin	0.980	0.930	1.240	1.040	0.970	0.800	0.680

Sms	KLA Compactin Compactin+KLA	NM_009214		spermine synthase (Sms), mRNA [NM_009214]	KLA	1.110	1.000	1.140	1.220	0.980	0.890	0.640
					Compactin	1.040	1.050	1.080	1.040	1.000	0.930	0.970
					KLA/Compactin	1.070	1.030	1.130	1.130	0.960	0.820	0.650

Srm	KLA Compactin Compactin+KLA	NM_009272	spermidine synthase (Srm), mRNA [NM_009272]	KLA	1.070	1.040	1.000	0.840	0.800	0.650	0.540
				Compactin	0.970	1.060	0.920	1.030	0.870	1.050	1.010
				KLA/Compactin	0.930	1.070	0.880	0.820	0.640	0.440	0.430

Upb1	KLA Compactin Compactin+KLA	NM_133995		ureidopropionase, beta (Upb1), mRNA [NM_133995]	KLA	0.940	0.990	1.060	0.960	1.000	1.070	0.990
					Compactin	0.930	0.970	1.070	1.070	1.010	1.000	1.010
					KLA/Compactin	1.000	0.980	1.020	1.050	0.980	0.990	1.000

Upb1	KLA Compactin Compactin+KLA	NM_133995	ureidopropionase, beta (Upb1), mRNA [NM_133995]	KLA	0.960	1.020	1.020	1.060	0.990	1.010	1.040
				Compactin	0.970	1.040	0.970	1.030	1.010	0.950	1.070
				KLA/Compactin	0.970	1.040	1.040	1.060	1.050	1.000	1.020

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: beta-Alanine metabolism (mmu00410)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios