Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Phenylalanine metabolism (mmu00360)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
1700055N 04Rik	KLA Compactin Compactin+KLA	94405716	RIKEN cDNA 1700055N04 gene	KLA	0.910	0.920	1.020	1.030	0.920	0.840	1.020
				Compactin	1.040	1.010	0.940	0.990	0.910	1.010	0.910
				KLA/Compactin	0.940	1.020	1.010	1.020	0.940	1.030	1.080

1700055N 04Rik	KLA Compactin Compactin+KLA	AK081788		16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788]	KLA	0.980	0.950	0.940	0.960	0.990	1.020	1.030
					Compactin	1.050	0.970	0.970	1.020	1.050	1.010	0.880
					KLA/Compactin	1.000	1.010	0.970	1.010	1.020	0.980	1.000

4930438A 08Rik	KLA Compactin Compactin+KLA	XM_001477470	gb\|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470]	KLA	0.910	0.990	0.990	1.000	1.560	4.520	10.370
				Compactin	0.960	1.000	1.030	0.970	0.930	0.960	1.050
				KLA/Compactin	0.960	0.990	1.010	1.090	1.630	5.840	12.850

Aldh1a3	KLA Compactin Compactin+KLA	AK086764		15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764]	KLA	1.000	1.030	0.980	1.000	1.020	1.060	0.940
					Compactin	1.020	1.020	1.060	1.050	1.010	0.980	1.040
					KLA/Compactin	0.990	1.270	0.990	1.080	1.020	0.970	1.030

Aldh1a3	KLA Compactin Compactin+KLA	NM_053080	aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080]	KLA	1.010	1.070	1.000	0.950	1.090	1.020	1.050
				Compactin	0.910	1.000	1.050	0.970	0.920	1.020	1.020
				KLA/Compactin	0.980	0.940	1.020	1.000	0.970	0.930	1.040

Aldh3a1	KLA Compactin Compactin+KLA	NM_007436		aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436]	KLA	1.010	1.050	1.100	0.970	0.990	1.000	0.960
					Compactin	0.980	1.010	1.010	0.980	1.050	0.970	1.040
					KLA/Compactin	1.000	1.000	0.960	1.070	1.020	1.020	1.040

Aldh3b1	KLA Compactin Compactin+KLA	NM_026316	aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316]	KLA	0.990	1.030	1.100	1.000	0.840	1.250	1.060
				Compactin	1.120	1.100	1.310	1.250	0.960	1.020	0.850
				KLA/Compactin	1.170	1.050	1.070	1.040	0.980	1.140	0.940

Aldh3b2	KLA Compactin Compactin+KLA	94405693		aldehyde dehydrogenase 3 family, member B2	KLA	1.010	1.010	0.960	0.970	0.940	1.030	0.980
					Compactin	1.050	1.080	0.980	1.010	1.150	0.980	1.020
					KLA/Compactin	0.980	0.950	1.000	1.020	0.980	1.000	1.050

Aldh3b2	KLA Compactin Compactin+KLA	XM_129134	gb\|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134]	KLA	0.900	0.870	0.920	0.990	1.040	1.080	1.040
				Compactin	0.860	0.950	0.900	0.930	0.920	0.950	0.850
				KLA/Compactin	0.940	0.880	0.890	1.040	0.880	1.010	1.150

Aoc2	KLA Compactin Compactin+KLA	NM_178932		amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932]	KLA	1.330	2.340	1.120	1.060	1.120	1.050	1.300
					Compactin	0.970	0.990	0.990	0.990	1.010	0.930	1.160
					KLA/Compactin	1.360	2.290	1.100	1.090	1.070	0.920	1.290

Aoc3	KLA Compactin Compactin+KLA	NM_009675	amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675]	KLA	0.960	1.060	1.040	1.070	1.050	1.040	1.030
				Compactin	0.960	1.070	0.970	0.960	1.020	1.050	1.020
				KLA/Compactin	0.980	0.990	1.000	0.950	1.000	1.030	1.030

Ddc	KLA Compactin Compactin+KLA	NM_016672		dopa decarboxylase (Ddc), mRNA [NM_016672]	KLA	1.070	0.970	0.960	1.000	1.050	0.990	0.990
					Compactin	0.960	0.980	1.000	0.940	1.060	1.000	0.960
					KLA/Compactin	0.990	1.030	0.970	1.050	0.930	0.960	0.990

Ddc	KLA Compactin Compactin+KLA	NM_016672	dopa decarboxylase (Ddc), mRNA [NM_016672]	KLA	1.090	1.020	0.920	0.990	1.040	0.940	1.020
				Compactin	1.030	1.030	1.060	0.950	1.000	1.040	0.990
				KLA/Compactin	0.940	0.930	0.990	0.960	0.960	1.090	0.980

Glyat	KLA Compactin Compactin+KLA	BC015294		glycine-N-acyltransferase, mRNA (cDNA clone MGC:19155 IMAGE:4220471), complete cds [BC015294]	KLA	1.050	0.990	0.970	1.010	0.960	0.990	1.020
					Compactin	0.990	0.990	1.040	0.940	1.010	0.980	0.960
					KLA/Compactin	1.040	0.980	0.960	1.010	1.010	1.090	0.990

Glyat	KLA Compactin Compactin+KLA	NM_145935	glycine-N-acyltransferase (Glyat), nuclear gene encoding mitochondrial protein, mRNA [NM_145935]	KLA	0.990	0.940	0.910	0.940	1.000	1.020	0.960
				Compactin	0.930	0.990	1.010	1.040	0.950	0.990	1.040
				KLA/Compactin	1.020	0.940	1.030	1.010	1.010	0.910	1.050

Got1	KLA Compactin Compactin+KLA	NM_010324		glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324]	KLA	0.990	0.960	0.820	0.740	0.780	1.140	1.350
					Compactin	1.110	1.060	1.070	1.250	0.950	0.700	0.640
					KLA/Compactin	1.020	1.050	0.850	0.770	0.760	1.070	1.070

Got2	KLA Compactin Compactin+KLA	NM_010325	glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325]	KLA	0.960	1.030	1.060	0.940	0.870	0.810	1.090
				Compactin	1.130	1.000	1.060	1.010	1.080	0.990	0.880
				KLA/Compactin	1.100	1.000	1.120	1.040	0.870	0.940	0.940

Hpd	KLA Compactin Compactin+KLA	NM_008277		4-hydroxyphenylpyruvic acid dioxygenase (Hpd), mRNA [NM_008277]	KLA	1.020	0.960	1.010	1.010	0.990	0.910	0.960
					Compactin	1.100	1.020	1.030	0.980	0.990	1.040	0.970
					KLA/Compactin	0.920	1.030	1.080	1.020	0.950	1.020	0.980

Il4i1	KLA Compactin Compactin+KLA	NM_010215	interleukin 4 induced 1 (Il4i1), mRNA [NM_010215]	KLA	1.160	1.780	6.000	7.610	4.240	1.830	0.970
				Compactin	1.000	1.090	1.000	1.040	0.830	0.820	1.690
				KLA/Compactin	1.260	2.060	5.680	8.020	5.700	2.690	1.220

Lao1	KLA Compactin Compactin+KLA	NM_133892		L-amino acid oxidase 1 (Lao1), mRNA [NM_133892]	KLA	1.040	0.950	0.920	1.020	0.930	1.010	0.920
					Compactin	1.030	0.990	1.130	1.010	1.060	1.010	0.960
					KLA/Compactin	0.970	0.930	0.980	1.050	0.970	1.030	0.970

Maoa	KLA Compactin Compactin+KLA	NM_173740	monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740]	KLA	0.940	1.000	1.120	1.210	1.160	0.950	1.190
				Compactin	0.870	0.940	0.870	0.820	0.970	0.940	1.020
				KLA/Compactin	0.920	1.050	1.160	0.990	0.950	1.030	1.460

Maob	KLA Compactin Compactin+KLA	NM_172778		monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778]	KLA	1.000	0.950	0.970	0.940	0.970	1.010	1.030
					Compactin	0.930	1.020	0.970	1.020	0.930	1.030	1.060
					KLA/Compactin	0.970	0.900	1.040	1.070	0.980	0.980	1.030

Mif	KLA Compactin Compactin+KLA	NM_010798	macrophage migration inhibitory factor (Mif), mRNA [NM_010798]	KLA	0.830	0.930	0.850	0.950	1.050	0.920	0.730
				Compactin	0.920	0.950	0.860	0.900	0.990	0.990	0.990
				KLA/Compactin	0.860	0.920	0.830	1.040	0.980	0.880	0.660

Pah	KLA Compactin Compactin+KLA	NM_008777		phenylalanine hydroxylase (Pah), mRNA [NM_008777]	KLA	0.960	0.980	1.050	0.990	0.990	1.060	1.000
					Compactin	0.970	1.020	0.980	1.020	1.070	0.980	0.910
					KLA/Compactin	1.050	0.980	1.050	0.970	1.040	0.990	0.950

Prdx6	KLA Compactin Compactin+KLA	AK081980	16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130091B17 product:peroxiredoxin 5, related sequence 3, full insert sequence [AK081980]	KLA	0.950	0.930	0.780	0.760	1.000	1.070	1.210
				Compactin	0.940	0.940	0.920	0.860	0.960	1.060	1.120
				KLA/Compactin	0.850	0.860	0.840	0.840	0.730	0.960	1.570

Prdx6	KLA Compactin Compactin+KLA	NM_007453		peroxiredoxin 6 (Prdx6), mRNA [NM_007453]	KLA	0.920	1.050	0.930	1.040	1.060	1.040	1.210
					Compactin	0.890	1.000	0.900	0.960	1.030	1.110	1.110
					KLA/Compactin	0.840	0.960	1.050	0.980	0.950	1.010	1.250

Prdx6	KLA Compactin Compactin+KLA	NM_007453	peroxiredoxin 6 (Prdx6), mRNA [NM_007453]	KLA	1.000	1.070	0.730	1.080	1.170	0.900	0.950
				Compactin	0.890	0.840	0.790	0.850	0.980	1.250	1.030
				KLA/Compactin	0.890	1.100	1.040	0.970	0.750	0.780	1.510

Prdx6	KLA Compactin Compactin+KLA	NM_007453		peroxiredoxin 6 (Prdx6), mRNA [NM_007453]	KLA	1.230	1.120	1.080	1.110	1.060	0.870	1.050
					Compactin	1.360	1.180	1.110	1.300	1.010	1.020	0.970
					KLA/Compactin	1.160	1.090	0.970	1.210	0.980	0.780	0.830

Tat	KLA Compactin Compactin+KLA	NM_146214	tyrosine aminotransferase (Tat), nuclear gene encoding mitochondrial protein, mRNA [NM_146214]	KLA	1.110	0.960	1.040	1.030	1.040	1.020	1.050
				Compactin	0.940	0.890	1.010	1.030	1.040	1.080	0.980
				KLA/Compactin	0.980	1.030	1.080	1.070	1.030	1.130	1.110

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Phenylalanine metabolism (mmu00360)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios