Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Primary bile acid biosynthesis (mmu00120)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Acot8
KLA  Compactin  Compactin+KLA
 NM_133240 acyl-CoA thioesterase 8 (Acot8), mRNA [NM_133240] KLA0.780 0.780 0.800 0.820 1.520 1.400 1.770
Compactin0.840 0.890 0.770 0.800 1.130 1.170 1.090
KLA/Compactin0.790 0.810 0.770 0.850 1.100 1.350 2.750
Acox2
KLA  Compactin  Compactin+KLA
 NM_053115 acyl-Coenzyme A oxidase 2, branched chain (Acox2), mRNA [NM_053115] KLA1.000 0.950 1.010 1.000 0.980 0.970 1.010
Compactin0.990 0.960 1.000 0.990 0.920 0.990 0.910
KLA/Compactin1.030 0.990 1.030 0.990 1.050 0.960 0.970
Acox2
KLA  Compactin  Compactin+KLA
 NM_053115 acyl-Coenzyme A oxidase 2, branched chain (Acox2), mRNA [NM_053115] KLA1.000 1.040 0.920 0.990 0.980 0.970 0.990
Compactin0.990 0.990 0.950 0.970 1.030 0.980 0.970
KLA/Compactin0.970 1.010 1.030 0.990 0.990 0.950 1.000
AK087232
KLA  Compactin  Compactin+KLA
 AK087232 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030037J19 product:unclassifiable, full insert sequence. [AK087232] KLA0.970 1.020 1.000 0.910 0.940 1.110 0.990
Compactin0.960 1.040 0.940 0.990 0.990 1.030 1.070
KLA/Compactin1.020 0.950 1.000 1.070 0.960 0.880 1.030
Akr1d1
KLA  Compactin  Compactin+KLA
 NM_145364 aldo-keto reductase family 1, member D1 (Akr1d1), mRNA [NM_145364] KLA1.050 1.030 1.000 1.000 1.000 1.030 0.970
Compactin0.900 0.980 0.970 0.910 1.050 1.010 0.960
KLA/Compactin0.990 0.980 0.960 1.060 1.020 0.930 1.050
Amacr
KLA  Compactin  Compactin+KLA
 NM_008537 alpha-methylacyl-CoA racemase (Amacr), mRNA [NM_008537] KLA0.990 0.990 0.800 0.700 0.600 0.630 0.500
Compactin0.880 1.100 1.200 0.930 0.900 0.930 0.840
KLA/Compactin0.840 0.950 0.960 0.820 0.580 0.570 0.440
Baat
KLA  Compactin  Compactin+KLA
 NM_007519 bile acid-Coenzyme A: amino acid N-acyltransferase (Baat), mRNA [NM_007519] KLA0.970 1.050 1.110 1.020 1.000 1.100 1.030
Compactin0.960 0.990 1.000 0.980 0.940 1.030 1.000
KLA/Compactin0.950 1.000 1.010 1.000 1.050 1.010 0.940
Baat
KLA  Compactin  Compactin+KLA
 NM_007519 bile acid-Coenzyme A: amino acid N-acyltransferase (Baat), mRNA [NM_007519] KLA1.000 1.140 1.010 1.030 0.980 1.020 0.940
Compactin0.870 1.030 1.000 1.010 1.020 0.940 1.010
KLA/Compactin0.950 1.160 1.030 1.050 1.010 0.960 0.940
Ch25h
KLA  Compactin  Compactin+KLA
 NM_009890 cholesterol 25-hydroxylase (Ch25h), mRNA [NM_009890] KLA0.970 1.010 1.130 1.330 1.050 1.130 1.000
Compactin0.910 0.960 0.950 0.980 1.030 0.960 1.070
KLA/Compactin1.060 0.930 1.040 1.380 1.110 1.030 1.040
Ch25h
KLA  Compactin  Compactin+KLA
 NM_009890 cholesterol 25-hydroxylase (Ch25h), mRNA [NM_009890] KLA1.000 0.980 1.080 1.390 1.140 0.990 1.290
Compactin1.040 0.980 0.960 0.990 1.040 1.040 0.930
KLA/Compactin0.990 0.980 1.060 1.260 1.140 0.980 0.910
Cyp27a1
KLA  Compactin  Compactin+KLA
 NM_024264 cytochrome P450, family 27, subfamily a, polypeptide 1 (Cyp27a1), nuclear gene encoding mitochondrial protein, mRNA [NM_024264] KLA0.950 0.940 0.910 0.790 0.670 0.690 0.740
Compactin0.900 0.950 0.980 0.960 0.910 0.910 0.940
KLA/Compactin0.950 0.930 0.820 0.730 0.740 0.710 0.640
Cyp39a1
KLA  Compactin  Compactin+KLA
 NM_018887 cytochrome P450, family 39, subfamily a, polypeptide 1 (Cyp39a1), mRNA [NM_018887] KLA1.000 1.000 1.000 0.930 0.960 1.000 0.970
Compactin1.030 1.020 1.000 0.940 1.060 1.030 1.020
KLA/Compactin1.000 0.970 0.980 0.990 1.040 1.100 0.990
Cyp39a1
KLA  Compactin  Compactin+KLA
 NM_018887 cytochrome P450, family 39, subfamily a, polypeptide 1 (Cyp39a1), mRNA [NM_018887] KLA1.050 1.030 0.980 0.930 1.010 1.030 0.930
Compactin0.960 0.940 0.960 1.030 0.960 1.010 0.930
KLA/Compactin0.980 0.920 1.020 1.030 0.930 0.910 1.030
Cyp46a1
KLA  Compactin  Compactin+KLA
 NM_010010 cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA [NM_010010] KLA1.080 0.960 0.990 1.110 1.050 1.030 1.050
Compactin1.060 0.920 1.070 1.050 1.110 1.030 1.010
KLA/Compactin1.000 0.960 1.040 1.030 1.050 1.050 1.020
Cyp7a1
KLA  Compactin  Compactin+KLA
 NM_007824 cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1), mRNA [NM_007824] KLA0.980 0.920 0.940 0.970 0.980 0.990 0.960
Compactin0.970 1.260 1.020 0.960 1.050 0.960 1.000
KLA/Compactin0.960 0.980 0.900 1.000 1.030 0.920 0.980
Cyp7a1
KLA  Compactin  Compactin+KLA
 NM_007824 cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1), mRNA [NM_007824] KLA1.040 0.980 1.020 0.980 0.960 0.970 1.170
Compactin0.980 1.050 1.000 1.020 0.930 0.960 1.010
KLA/Compactin1.020 1.030 0.980 0.890 0.960 0.980 1.030
Cyp7a1
KLA  Compactin  Compactin+KLA
 NM_007824 cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1), mRNA [NM_007824] KLA1.050 0.970 1.000 1.030 1.030 1.010 0.990
Compactin1.050 0.940 1.040 1.020 0.980 1.020 0.970
KLA/Compactin1.020 0.970 0.990 1.040 1.000 0.970 1.050
Cyp7b1
KLA  Compactin  Compactin+KLA
 NM_007825 cytochrome P450, family 7, subfamily b, polypeptide 1 (Cyp7b1), mRNA [NM_007825] KLA0.970 1.010 1.030 1.060 1.000 0.990 0.990
Compactin1.230 0.960 1.000 1.000 1.070 0.980 1.010
KLA/Compactin1.130 1.020 1.080 1.080 0.970 1.020 0.980
Cyp8b1
KLA  Compactin  Compactin+KLA
 NM_010012 cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1), mRNA [NM_010012] KLA0.900 0.980 1.010 0.980 1.010 1.070 1.090
Compactin1.000 1.000 0.990 1.020 1.020 1.010 1.080
KLA/Compactin1.020 0.960 0.970 0.940 1.040 0.920 1.010
Hsd17b4
KLA  Compactin  Compactin+KLA
 NM_008292 hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4), mRNA [NM_008292] KLA0.970 0.990 1.030 0.940 0.750 0.780 1.000
Compactin0.970 0.920 0.950 1.040 0.970 0.940 0.960
KLA/Compactin1.000 0.990 0.860 0.880 0.950 0.950 1.010
Hsd3b7
KLA  Compactin  Compactin+KLA
 NM_133943 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 (Hsd3b7), transcript variant 1, mRNA [NM_133943] KLA0.920 0.790 0.700 0.550 0.810 1.000 0.780
Compactin0.910 1.040 0.970 0.890 1.120 0.940 1.090
KLA/Compactin0.910 0.780 0.720 0.520 0.840 1.030 0.710
Scp2
KLA  Compactin  Compactin+KLA
 NM_011327 sterol carrier protein 2, liver (Scp2), mRNA [NM_011327] KLA0.920 0.840 0.790 0.780 0.540 0.510 0.600
Compactin0.910 0.970 0.850 0.880 1.110 0.900 0.720
KLA/Compactin0.900 0.880 0.820 0.650 0.540 0.530 0.670
Scp2
KLA  Compactin  Compactin+KLA
 NM_011327 sterol carrier protein 2, liver (Scp2), mRNA [NM_011327] KLA0.920 0.900 0.860 0.820 0.700 0.610 0.700
Compactin0.890 0.900 1.020 0.970 1.010 0.990 0.880
KLA/Compactin0.850 0.920 0.890 0.710 0.680 0.600 0.700
Slc27a5
KLA  Compactin  Compactin+KLA
 6678010 solute carrier family 27 (fatty acid transporter), member 5 KLA1.030 0.950 0.950 0.890 1.010 1.050 0.990
Compactin0.960 0.990 0.970 1.010 0.950 0.980 0.930
KLA/Compactin0.980 0.990 0.960 0.990 0.950 0.910 1.010
Slc27a5
KLA  Compactin  Compactin+KLA
 NM_009512 solute carrier family 27 (fatty acid transporter), member 5 (Slc27a5), mRNA [NM_009512] KLA0.950 0.980 0.990 1.040 0.930 0.970 1.010
Compactin0.890 1.020 1.010 1.000 0.990 0.980 1.010
KLA/Compactin0.990 0.980 1.010 0.980 0.970 0.970 0.940