LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP013304

UniProt Annotations

Entry Information
Gene Namevitamin K epoxide reductase complex, subunit 1
Protein EntryVKOR1_RAT
UniProt IDQ6TEK4
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl- 1,4-naphthoquinone + 1,4-dithiothreitol. {ECO:0000269|PubMed:15640149, ECO:0000269|PubMed:23772386, ECO:0000269|PubMed:23928358}.
DomainThe number of transmembrane domains and the membrane topology are controversial; supporting evidence is available both for models with three transmembrane domains and four transmembrane domains
Enzyme RegulationInhibited by warfarin (coumadin). {ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:23772386, ECO:0000269|PubMed:23928358}.
FunctionInvolved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:15640149, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:23772386, ECO:0000269|PubMed:23928358}.
MiscellaneousThe location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin).
SimilarityBelongs to the VKOR family
Subcellular LocationEndoplasmic reticulum membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:23772386, ECO:0000269|PubMed:23928358}.
Tissue SpecificityHighly expressed in liver. Detected at lower levels in lung, kidney and testis