LMPD Database

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LMP012736

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member A1 (aldehyde reductase)
Protein EntryAK1A1_RAT
UniProt IDP51635
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAn alcohol + NADP(+) = an aldehyde + NADPH.
FunctionCatalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Catalyzes the NADPH-dependent reduction of 3-deoxyglucosone (3-DG)
SimilarityBelongs to the aldo/keto reductase family
SubunitMonomer