LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012490

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 24, subfamily a, polypeptide 1
Protein EntryCP24A_RAT
UniProt IDQ09128
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=2.8 uM for calcidiol ; pH dependence: Optimum pH is 7.7. ;
Catalytic ActivityCalcidiol + NADPH + O(2) = secalciferol + NADP(+) + H(2)O
Catalytic ActivityCalcitriol + NADPH + O(2) = calcitetrol + NADP(+) + H(2)O
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
FunctionHas a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.
SimilarityBelongs to the cytochrome P450 family
Subcellular LocationMitochondrion.