LMPD Database

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LMP012490

Record overview

LMPD IDLMP012490
Gene ID25279
SpeciesMacaca mulata (Rhesus monkey)
Gene Namecytochrome P450, family 24, subfamily a, polypeptide 1
Gene SymbolCyp24a1
SynonymsCyp24; VITD12; 25-hydroxyvitaminD324-hydroxylase;
Alternate names1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; 24R-Ohase; P450-CC24; cytochrome P450 24A1; cytochrome P450-CC24; vitamin D(3) 24-hydroxylase; cytochrome P450, subfamily 24; 25-hydroxyvitamin D3 24-hydroxylase; Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase);
Chromosome3
Map Location3q42
EC Number1.14.13.126
Summaryenzyme involved in vitamin D metabolism; linked to albuminuria, hyperlipidemia and atherosclerotic aorta lesions [RGD, Feb 2006]
OrthologsView orthologs and multiple alignments for Cyp24a1

Proteins

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor
Refseq ID:NP_963966
Protein GI:42761472
UniProt ID:Q09128
mRNA ID:NM_201635
Length:514
RefSeq Status:
MSCPIDKRRTLIAFLRRLRDLGQPPRSVTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMK
LGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRI
PDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGAD
FLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDK
PTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGI
LVPSRELPIAFRPR
 

transit_peptide: 1..35
experiment: experimental evidence, no additional details recorded
note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (Q09128.1)
calculated_mol_wt: 3929
peptide sequence: 
MSCPIDKRRTLIAFLRRLRDLGQPPRSVTSKASAS

mat_peptide: 36..514
product: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q09128.1)
calculated_mol_wt: 55538
peptide sequence: 
RAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWK
AYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA
LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSL
MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKF
RPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR