LMPD Database

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LMP012394

UniProt Annotations

Entry Information
Gene Namecalmodulin 1
Protein EntryCALM_RAT
UniProt IDP62161
SpeciesRat
Comments
Comment typeDescription
FunctionCalmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity)
InteractionP00533:EGFR (xeno); NbExp=6; IntAct=EBI-397530, EBI-297353; Q14451:GRB7 (xeno); NbExp=9; IntAct=EBI-397530, EBI-970191; P23711:Hmox2; NbExp=2; IntAct=EBI-397530, EBI-2910092; P70604:Kcnn2; NbExp=2; IntAct=EBI-397530, EBI-1031103; O88943:Kcnq2; NbExp=4; IntAct=EBI-397530, EBI-7900557; P38377:SEC61A1 (xeno); NbExp=4; IntAct=EBI-397530, EBI-8517797; P52888:THOP1 (xeno); NbExp=2; IntAct=EBI-397530, EBI-372399; P24155:Thop1; NbExp=2; IntAct=EBI-397530, EBI-6372841;
MiscellaneousThis protein has four functional calcium-binding sites.
PtmPhosphorylation results in a decreased activity
PtmUbiquitination results in a strongly decreased activity
SimilarityBelongs to the calmodulin family
SimilarityContains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationCytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules
SubunitInteracts with CEP97, CCP110, MYO1C, TTN/titin and SRY. Interacts with MYO10 and MYO5A. Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with RRAD. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. {ECO:0000250, ECO:0000269|PubMed:18056528, ECO:0000269|PubMed:23109337}.