LMPD Database

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LMP009167

UniProt Annotations

Entry Information
Gene NameCG16982 gene product from transcript CG16982-RC
Protein EntryRBX1A_DROME
UniProt IDX2JA05
SpeciesDrosophila
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically. {ECO:0000269|PubMed:12062088}.
DomainThe RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity). {ECO:0000250}.
FunctionComponent of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. {ECO:0000269|PubMed:12062088}.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=CAA20888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the RING-box family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular LocationCytoplasm. Nucleus.
SubunitPart of a SCF complex consisting of Skpa (SKP1), Lin19 (CUL1), Roc1A and F-box protein Slmb. Interacts directly with Lin19 and Slmb. {ECO:0000269|PubMed:11500045}.
Tissue SpecificityWidely expressed. Expressed in embryonic, larval and adult tissues. {ECO:0000269|PubMed:12062088}.